Adverse events following influenza immunization: understanding the role of age and sex interactions

Bohn‐Goldbaum, Erika; Cross, Troy J.; Leeb, Alan; Peters, Ian; Booy, Robert; Edwards, Kate M.

doi:10.1080/14760584.2022.2021075

Cited by 7 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the function of the immune system evolves over time, and aging and senescence of the immune system are thought to be related to systemic aging, with increased risk of morbidity and mortality 35,37 . Moreover, female participants experienced higher vaccine‐related adverse reaction rates, consistent with previous findings from a retrospective analysis of over 300 000 patients from Australia and a systematic review based on more than 1000 studies 38,39 . Reasons for the gender‐related differences in reactogenicity may be due to genetic or hormonal differences 40 .…”

Section: Discussionsupporting

confidence: 79%

“…35,37 Moreover, female participants experienced higher vaccine-related adverse reaction rates, consistent with previous findings from a retrospective analysis of over 300 000 patients from Australia and a systematic review based on more than 1000 studies. 38,39 Reasons for the gender-related differences in reactogenicity may be due to genetic or hormonal differences. 40 Although increased body weight has been identified as a predictor of vaccine-related adverse reactions, no such relationship was observed in INVESTED, while studies suggest that increased reactogenicity in obese individuals is probably related primarily to injection technique.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of post‐vaccination adverse reactions after influenza vaccine with mortality and cardiopulmonary outcomes in patients with high‐risk cardiovascular disease: the INVESTED trial

Peikert

Claggett

Kim

et al. 2022

European J of Heart Fail

View full text Add to dashboard Cite

Influenza vaccination is associated with reduced cardiopulmonary morbidity and mortality among patients with heart failure or recent myocardial infarction. The immune response to vaccination frequently results in mild adverse reactions (AR), which leads to vaccine hesitancy. This post hoc analysis explored the association between vaccine-related AR and morbidity and mortality in patients with high-risk cardiovascular disease.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Association of post‐vaccination adverse reactions after influenza vaccine with mortality and cardiopulmonary outcomes in patients with high‐risk cardiovascular disease: the INVESTED trial

Peikert

Claggett

Kim

et al. 2022

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

“…A different conclusion was found in a recent study published by Bohn-Goldman et al using data from active surveillance of over 300 000 participants. 48 They noticed a complex interaction between age and sex, with a higher OR of AEFIs in females, which was more pronounced for those between 30 and 70 years of age. Although small differences may exist in the frequency of ISR between the QIV and the TIV vaccine, 49 we did not find heterogeneity between vaccine types for both younger and older participants.…”

Section: Discussionmentioning

confidence: 95%

Sex differences in adverse events following seasonal influenza vaccines: a meta-analysis of randomised controlled trials

Kiely,

Tadount,

et al. 2023

J Epidemiol Community Health

View full text Add to dashboard Cite

BackgroundDespite being a vaccine-preventable disease, influenza remains a major public health threat with vaccine safety concerns reducing vaccine acceptability. Immune responses to vaccines and adverse events may differ between males and females, but most studies do not report results by sex. Using data from clinical trials, we explored sex differences in adverse events following seasonal influenza vaccines.MethodsWe obtained data for phase III randomised controlled trials identified through a systematic review and clinical trials registries, and performed a two-stage meta-analysis. Risk ratios (RR) and 95% confidence intervals (95% CI) comparing solicited reactions in femalesversusmales were pooled using the Mantel-Haenszel method and a random-effects model. We used the ROBINS-I tool to assess risk of bias and the I2statistic for heterogeneity. Main analysis was stratified by age: 18–64 years and ≥65 years.ResultsThe dataset for this analysis included 34 343 adults from 18 studies (12 with individual-level data and 6 with aggregate data). There was a higher risk of injection site reactions in females compared with males for both younger and older participants, with RRs of 1.29 (95% CI 1.21 to 1.37) and 1.43 (95% CI 1.28 to 1.60), respectively. Higher risk in females was also observed for systemic reactions, with RRs of 1.25 (95% CI 1.20 to 1.31) and 1.27 (95% CI 1.20 to 1.34) for younger and older participants, respectively. We also observed elevated risks of severe reactions in females, with a higher RR in youngerversusolder participants for systemic reactions (RRs 2.12 and 1.48, p=0.03, I2=79.7%). RRs were not found to vary between quadrivalent and trivalent vaccines.ConclusionThis meta-analysis suggested a higher risk of solicited reactions following influenza vaccines for females compared with males, irrespective of age and vaccine type. Transparent communication of this risk could increase the trust in vaccines and limit vaccine hesitancy. Future studies should report results stratified by sex and explore the role of gender in the occurrence of adverse events.

show abstract

“…Just one study considered the effect of chronotype and reported no association with vaccination outcome (Matryba et al, 2022). One study considered circadian timing; Bohn-Goldbaum et al (2022) reported no association between the interval between vaccination and wake time and adverse events post vaccination. The associations between TODV and outcome were thought to be stronger in aged participants in two studies (Kurupati et al, 2017; Liu et al, 2022), although there was considerable variability among vaccine types.…”

Section: Resultsmentioning

confidence: 99%

“…Immune status at baseline was accounted for in most studies by measuring antibody titers before vaccination, and/or by reporting previous vaccination and infection history but 6 studies did not assess prior vaccination or infection status at baseline (Abbaspour et al, 2022; Bohn-Goldbaum et al, 2022; Kurupati et al, 2017; Langlois et al, 1995; Long et al, 2016; Phillips et al, 2008; Zhang et al, 2021; Suppl. Table S2).…”

Section: Resultsmentioning

confidence: 99%

Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal

Wyse,

Rudderham,

Nordon

et al. 2024

J Biol Rhythms

View full text Add to dashboard Cite

Molecular timing mechanisms known as circadian clocks drive endogenous 24-h rhythmicity in most physiological functions, including innate and adaptive immunity. Consequently, the response to immune challenge such as vaccination might depend on the time of day of exposure. This study assessed whether the time of day of vaccination (TODV) is associated with the subsequent immune and clinical response by conducting a systematic review of previous studies. The Cochrane Library, PubMed, Google, Medline, and Embase were searched for studies that reported TODV and immune and clinical outcomes, yielding 3114 studies, 23 of which met the inclusion criteria. The global severe acute respiratory syndrome coronavirus 2 vaccination program facilitated investigation of TODV and almost half of the studies included reported data collected during the COVID-19 pandemic. There was considerable heterogeneity in the demography of participants and type of vaccine, and most studies were biased by failure to account for immune status prior to vaccination, self-selection of vaccination time, or confounding factors such as sleep, chronotype, and shiftwork. The optimum TODV was concluded to be afternoon (5 studies), morning (5 studies), morning and afternoon (1 study), midday (1 study), and morning or late afternoon (1 study), with the remaining 10 studies reporting no effect. Further research is required to understand the relationship between TODV and subsequent immune outcome and whether any clinical benefit outweighs the potential effect of this intervention on vaccine uptake.

show abstract

Adverse events following influenza immunization: understanding the role of age and sex interactions

Cited by 7 publications

References 39 publications

Association of post‐vaccination adverse reactions after influenza vaccine with mortality and cardiopulmonary outcomes in patients with high‐risk cardiovascular disease: the INVESTED trial

Association of post‐vaccination adverse reactions after influenza vaccine with mortality and cardiopulmonary outcomes in patients with high‐risk cardiovascular disease: the INVESTED trial

Sex differences in adverse events following seasonal influenza vaccines: a meta-analysis of randomised controlled trials

Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal

Contact Info

Product

Resources

About