Adverse events in patients with leprosy on treatment with thalidomide

Drummond, Paula Lana de Miranda; Santos, Roberta Márcia Marques dos; Carvalho, Gabriela Oliveira; Pádua, Cristiane Aparecida Menezes de

doi:10.1590/0037-8682-0385-2018

Cited by 8 publications

(11 citation statements)

References 8 publications

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“…In our previous study (Drummond, 2019), we performed an active search for the adverse events in patients with leprosy using thalidomide at the same outpatient dermatology service of the present study. We found 1,278 adverse events recorded in the medical records of 110 patients within a period of one year of medical attendance.…”

Section: Discussionmentioning

confidence: 99%

“…Data on adverse events to thalidomide was obtained through review of medical charts and interview of 110 patients with erythema nodosum leprosum in a crosssectional study previously carried out by the authors (Drummond, 2019). Interviews were carried out between July and October 2016 and adverse events to thalidomide were reviewed in the medical records up to 12 months preceding the interviews.…”

Section: Identification Of Adverse Event In Outpatient Servicementioning

confidence: 99%

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Pharmacovigilance of thalidomide in the Brazilian Health System and patient safety

Drummond

Santos

Silva

et al. 2020

Braz. J. Pharm. Sci.

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Section: Discussionmentioning

confidence: 99%

Section: Identification Of Adverse Event In Outpatient Servicementioning

confidence: 99%

Pharmacovigilance of thalidomide in the Brazilian Health System and patient safety

Drummond

Santos

Silva

et al. 2020

Braz. J. Pharm. Sci.

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“…Given this patient’s prolonged exposure to thalidomide treatment over several years, it also remains possible that his neuritis is secondary to adverse drug effect of thalidomide, as peripheral neuropathy has been described in patients undergoing thalidomide treatment for leprosy [ 9 ] as well as multiple myeloma [ 10 ]. These patients demonstrated sensory length-dependent neuropathy presenting as painful paraesthesias or numbness, with greater degeneration correlating to total cumulative dose of thalidomide.…”

Section: Discussionmentioning

confidence: 99%

Late-onset ulnar neuritis following treatment of lepromatous leprosy infection

Wellington

Schofield

2019

PLoS Negl Trop Dis

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Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed leprosy reactions) can also manifest as neuritis at any point during infection. Treatment of leprosy reactions with thalidomide can also lead to neuritis due to an adverse drug effect. Neuritis can emerge years after initial diagnosis and treatment, although it is most frequently found at time of diagnosis or early into the treatment course. Treatment of neuritis is dependent on high-dose corticosteroid therapy as well as therapy for suspected underlying etiology. Here, we present a case of ulnar neuritis presenting in a patient with lepromatous leprosy four years after treatment of initial infection, with subsequent improvement after corticosteroid burst while maintained on thalidomide therapy.

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“…A study of adverse effects of thalidomide was performed in HEM-FHEMIG and DVT were recorded in the use of the association thalidomide and systemic corticosteroid in patients with ENL [20]. HEM-FHEMIG is a Reference Center of leprosy and is aware in order to ensure timely diagnosis, treatment and prevention of complications [21, 22].…”

Section: Discussionmentioning

confidence: 99%

Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais

Porto

Grossi²,

Alecrim

et al. 2019

Case Reports in Dermatological Medicine

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Introduction. Erythema nodosum leprosum (ENL) is a type of lepra reaction treated with corticosteroids and thalidomide, but this association increases the risk of deep venous thrombosis (DVT). Objective. To report cases of ENL with DVT in the use of thalidomide/corticosteroid associated. Methodology. The study was conducted between December 2015 and December 2016 at the Eduardo de Menezes Hospital (HEM-FHEMIG). Results. A clinical case series of 16 patients, eight from HEM-FHEMIG and eight from the literature. DVT occurred on 4 continents, mainly in adults and men. All patients were multibacillary; four people had pulmonary embolism (PE); there were 11 unilateral and five bilateral DVT cases; 12 cases were proximal, two distal, and two unspecified. Pharmacological thromboprophylaxis was used on two individuals. Outcome after DVT, 14 patients improved, one had sequelae, and one died. Discussion. DVT increased in association with thalidomide/corticosteroid in multiple myeloma, but this complication is poorly described in ENL. In proximal DVT, there was a greater risk of PE and sequelae venous insufficiency. After DVT, start anticoagulation. ASA 100mg/day as prophylaxis for DVT in case of this drug association in ENL is recommended. Conclusion. The article illustrates the incidence increase of DVT because of the thalidomide/corticosteroid combination in ENL. When this association is necessary, use ASA 100mg/day as prophylaxis.

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Adverse events in patients with leprosy on treatment with thalidomide

Cited by 8 publications

References 8 publications

Pharmacovigilance of thalidomide in the Brazilian Health System and patient safety

Pharmacovigilance of thalidomide in the Brazilian Health System and patient safety

Late-onset ulnar neuritis following treatment of lepromatous leprosy infection

Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais

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