Adverse Events of Antibiotics Used to Treat Acute Otitis Media in Children: A Systematic Meta-Analysis

Hum, Stephanie W.; Shaikh, Kai; Musa, Samar S.; Shaikh, Nader

doi:10.1016/j.jpeds.2019.08.043

Cited by 24 publications

(21 citation statements)

References 18 publications

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“…This may have been due to the broadspectrum action of AMPC/CVA, a risk factor for AAD. 8) Notably, most of these patients (95.9 and 97.6%, respectively) were administered antibiotic-resistant probiotics (Table 1). In vitro, probiotics using E. faecalis that were included in RLABP have high minimum inhibitory concentrations (MIC) against ampicillin (the in vitro activity of ampicillin is similar to that of AMPC).…”

Section: Discussionmentioning

confidence: 99%

“…As described above, AMPC and AMPC/CVA are associated with a high risk of AAD, and the preventive effectiveness of probiotics has been established. 4,[6][7][8][9]15) If probiotics are not used concomitantly, it cannot be simply concluded as an "inappropriate prescription." [10][11][12]15) However, considering our results that the proportions of probiotic prescriptions were less than 50%, except for specific populations, clinicians should consider the clinical usefulness of probiotics for children receiving AMPC and AMPC/CVA.…”

Section: Discussionmentioning

confidence: 99%

“…4,5) Amoxicillin (AMPC) and amoxicillin/clavulanate (AMPC/CVA) are considered to be associated with a high risk of AAD. 4,[6][7][8][9] For example, in a meta-analysis targeting pediatric patients with otitis media, the occurrence of diarrhea was highest in children receiving high-dose AMPC/CVA. 9) However, they are important antibiotics in the pediatric field.…”

Section: Introductionmentioning

confidence: 99%

“…4,[6][7][8][9] For example, in a meta-analysis targeting pediatric patients with otitis media, the occurrence of diarrhea was highest in children receiving high-dose AMPC/CVA. 9) However, they are important antibiotics in the pediatric field. [10][11][12][13] Indeed, in acute otitis media and respiratory tract infections, either AMPC or AMPC/CVA is recommended as the first-line treatment.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Probiotic Prescription Status of Pediatric Patients with Otitis Media Receiving Oral Amoxicillin or Amoxicillin/Clavulanate from April 2016 to March 2017 Using a Japanese Health Insurance Claims Database

Imai

Momo

Kashiwagi

et al. 2021

Biological & Pharmaceutical Bulletin

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Antibiotic-associated diarrhea (AAD) is a typical side effect of antibiotic treatment, especially in children. Amoxicillin (AMPC) and amoxicillin/clavulanate (AMPC/CVA) are associated with high risk of AAD; however, these antibiotics are important in the pediatric field. Recent research suggests that probiotics prevent pediatric AAD, including that caused by AMPC and AMPC/CVA. Indeed, guidelines for acute otitis media in children recommend the concomitant use of probiotics. However, the prescription status of probiotics for pediatric patients with otitis media receiving oral AMPC and AMPC/CVA remains unknown. We therefore conducted a survey to clarify the current status of these prescriptions and, in particular, to identify specific populations with a low proportion of probiotic prescriptions. Pediatric patients (≤15 years of age) newly prescribed oral AMPC or AMPC/CVA for otitis media between April 2016 and March 2017 were identified from a Japanese health insurance claims database. Eligible patients were divided into the AMPC (1303 patients) and AMPC/CVA (424 patients) groups, in which 659 (50.6%) and 293 (69.1%) patients were prescribed probiotics, respectively. Of the patients receiving probiotic prescriptions in the AMPC and AMPC/CVA groups, 632 (95.9%) and 286 (97.6%) patients received antibiotic-resistant probiotic prescriptions, respectively. When classified by the prescribing clinical department and patient age, the proportions of probiotic prescriptions in Internal Medicine and Pediatrics departments were lower than those in the Otorhinolaryngology department regardless of age. These results indicate the probability of insufficient probiotic prescriptions for pediatric patients with otitis media. Solving this issue may lead to the provision of safer antimicrobial therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Probiotic Prescription Status of Pediatric Patients with Otitis Media Receiving Oral Amoxicillin or Amoxicillin/Clavulanate from April 2016 to March 2017 Using a Japanese Health Insurance Claims Database

Imai

Momo

Kashiwagi

et al. 2021

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…As a result, oral cephalosporins, trimethoprim-sulfamethoxazole, and macrolides have lost their efficacy over time 22 . In addition to antibiotic stewardship, correct initial diagnosis of AOM can reduce the incidence of adverse events from antimicrobials, rash and diarrhea being most frequent 23 . It is estimated that antibiotics are given without indication in 32% of cases 24 .…”

Section: Introductionmentioning

confidence: 99%

Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach

Kashani

Młyńczak

Zarabanda

et al. 2021

Sci Rep

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Otitis media, a common disease marked by the presence of fluid within the middle ear space, imparts a significant global health and economic burden. Identifying an effusion through the tympanic membrane is critical to diagnostic success but remains challenging due to the inherent limitations of visible light otoscopy and user interpretation. Here we describe a powerful diagnostic approach to otitis media utilizing advancements in otoscopy and machine learning. We developed an otoscope that visualizes middle ear structures and fluid in the shortwave infrared region, holding several advantages over traditional approaches. Images were captured in vivo and then processed by a novel machine learning based algorithm. The model predicts the presence of effusions with greater accuracy than current techniques, offering specificity and sensitivity over 90%. This platform has the potential to reduce costs and resources associated with otitis media, especially as improvements are made in shortwave imaging and machine learning.

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Antibiotics for chronic pulmonary infection in children with a neurodisability (neurodevelopmental disorder)

Sanner

Jain

Williams

et al. 2020

Cochrane Database of Systematic Reviews

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Adverse Events of Antibiotics Used to Treat Acute Otitis Media in Children: A Systematic Meta-Analysis

Cited by 24 publications

References 18 publications

Probiotic Prescription Status of Pediatric Patients with Otitis Media Receiving Oral Amoxicillin or Amoxicillin/Clavulanate from April 2016 to March 2017 Using a Japanese Health Insurance Claims Database

Probiotic Prescription Status of Pediatric Patients with Otitis Media Receiving Oral Amoxicillin or Amoxicillin/Clavulanate from April 2016 to March 2017 Using a Japanese Health Insurance Claims Database

Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach

Antibiotics for chronic pulmonary infection in children with a neurodisability (neurodevelopmental disorder)

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