Adverse Events Profile of COVID-19 Preventative Strategies

Abstract

The COVID-19 pandemic has caused millions of deaths and has affected most people across the world, either directly or indirectly. Many preventative and therapeutic strategies have been employed since the beginning of the pandemic. With the development of the mRNA vaccine within a year of the start of the pandemic, we are entering a new era of vaccinology, and the adverse event profile of the COVID-19 vaccine is also becoming more apparent with time. While the benefits of the vaccines and other preventative strategies certainly outweigh the risk of adverse events, prospective clinical trials are urgently needed to determine whether specific populations, including those with a personal or family history of autoimmune disease, are at higher risk of developing certain adverse events, in order to minimize risk further.

COVID-19 Vaccine Clinical Trials: A Bird’s Eye Perspective

“…The incidence of unintentional adverse events, severe adverse events, and serious adverse events recorded within the 28 days after injection, on the other hand, was almost the same in the vaccination and control groups. Cardiac adverse events like pericarditis, AF and myocarditis were reported much more often in patients with second doses of vaccination as reported by the VAERS database [12].…”

“…Post-vaccination cardiac adverse events have been reported by the vaccine adverse event reporting system (VAERS) database with the highest risk of atrial fibrillation (AF) [12]. Among the vaccines, BNT162b2 has been found to have the highest incidence of AF.…”

“…The evidence on vaccine effectiveness and safety for people with comorbidities and particular diseases has been in recent studies There was the highest incidence and death from diabetes post-vaccination of Ad26.COV2.S as compared to other vaccines [12]. The vaccination effectiveness in obese individuals was reported in the BNT162b2 trial.…”

Machine learning based model for detecting depression during Covid-19 crisis

“…Depending on the scope, it can be divided into three categories: sentiment classification at the word level, sentiment analysis at the sentence level, and sentiment analysis at the sub-sentence or phrase level. [ 36 , 37 ]. The highest level of communication in society is social networking.…”

Otovestibular Symptoms of COVID-19 and Its Vaccines/Treatments

“…As of this writing, several vaccines have received FDA approval for use [91][92][93]. A broader review of possible adverse effects associated with the vaccines can be found elsewhere in this volume [94]. Researchers have received questions from patients regarding whether the vaccines themselves can cause otovestibular symptoms or exacerbate preexisting otovestibular diseases.…”