Adverse Events Related to COVID-19 Vaccines Reported in Pregnant Women in Brazil

Kobayashi, Carla Dinamerica; Pôrto, Victor Bertollo Gomes; Nóbrega, Martha Elizabeth Brasil da; Cabral, Cibelle Mendes; Barros, Tiago Dahrug; Roteli-Martins, Cecília Maria

doi:10.1055/s-0042-1755461

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…A deficiency in sulfur-containing thiamine has been linked to many neuropsychiatric adverse effects. As in long-COVID, activated immune-inflammatory and oxidative and nitrosative stress pathways (IO&NS) can underlie the physiological symptoms of COVID-19 vaccine-induced chronic fatigue syndrome, major depression, and generalized anxiety disorder 140,258,259 , which are characterized by activated IO&NS pathways. Therefore, the combination of toxicity from neuro-oxidative stress and diminished antioxidant defenses can result in increased neurotoxicity, ultimately leading to physiological symptoms 187 .…”

Section: Neurological Symptomsmentioning

confidence: 99%

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COVID-19 vaccine adverse events: Evaluating the pathophysiology from an undersulfated and degraded glycocalyx perspective

Preez,

Lin,

Maguire

et al. 2023

Preprint

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In this literature review, we assess the pathophysiology of severe adverse events observed after vaccination with DNA and mRNA vaccines against COVID-19, despite reports of their overall effectiveness. The focus is on the perspective of an undersulfated and degraded glycocalyx, considering its impact on immunomodulation, inflammatory responses, coagulation, and oxidative stress. The paper explores various factors that lead to glutathione and inorganic sulfate depletion and their subsequent effect on glycocalyx sulfation and other metabolites, including hormones. Components of COVID-19 vaccines, such as DNA and mRNA material, spike protein antigen, and lipid nanoparticles, are involved in possible cytotoxic effects. The common thread connecting these adverse events is endotheliopathy or glycocalyx degradation caused by depleted glutathione and inorganic sulfate levels, shear stress from circulating nanoparticles, aggregation, and formation of protein coronas, leading to imbalanced immune responses and chronic release of pro-inflammatory cytokines, ultimately resulting in oxidative stress and systemic inflammatory response syndrome. By understanding the underlying pathophysiology of severe adverse events, better treatment options can be explored.

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Section: Neurological Symptomsmentioning

confidence: 99%

“…In addition, spontaneous abortions and stillbirths could be expected when the mother has been vaccinated 258,278 , either recently before or during pregnancy 279 . The movement of nutrient-rich HSA across the placental barrier is controlled by clathrin-enabled endocytosis.…”

Section: Endocrine Disorders Reproductive Health and Pregnancymentioning

confidence: 99%

COVID-19 vaccine adverse events: Evaluating the pathophysiology from an undersulfated and degraded glycocalyx perspective

Preez,

Lin,

Maguire

et al. 2023

Preprint

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“…O presente estudo trata-se de uma revisão literatura, sobre as complicações gestacionais ocasionadas pela infecção do vírus O Quadro 1 resume os artigos incluídos, contendo informações de autor e ano, tipo de pesquisa, objetivo da pesquisa, e principais resultados encontrados. a partir de um processo secundário à síndrome trombocitopênica trombótica após a vacina AstraZeneca/FioCruz (KOBAYASHI et al, 2022).…”

Section: Materiais E Métodosunclassified

Complicações Da Covid-19 No Período Gestacional: Revisão Integrativa

Silva,

Rocha,

Ribeiro

et al. 2023

Braz. J. Implantol. Health Sci.

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A infecção por COVID-19 apresentou alta taxa, globalmente, de transmissão, com perfis de acometimento que variam desde doença leve, como na maioria dos infectados, até casos graves. Além disso, quadros de infecção por SARS-CoV-2, durante o período gestacional, predispõem à um maior risco de nascimento prematuro e morte perinatal, em decorrência, de indução iatrogênica de partos prematuros, como tentativa de salvar um paciente gravemente doente, e alterações inflamatórias sistêmicas que afetam a placenta. Dessa forma, o presente estudo trata-se de uma revisão de literatura sobre as complicações gestacionais ocasionadas pela infecção do vírus SARS-CoV-2, na qual foram incluídos 14 artigos, com base em busca em base de dados eletrônicas. As pacientes expostas ou infectadas pelo SARS-CoV-2 apresentaram maior incidência de parto prematuro, cesariana, necessidade de reanimação em sala de parto, índice de Apgar < 7 no 5° minuto, internação em unidade terapia intensiva e quadros de icterícia. Ademais, durante a quarta onda (Delta), a duração das hospitalizações dos pacientes se mostrou a mais longa, sendo em média 111 dias; a frequência de pneumonia confirmada por raios X e a necessidade de suporte de oxigênio não invasivo foram as mais altas. Assim, conclui-se que foi possível observar um número crescente de complicações maternas e desfechos neonatais não favoráveis ao recém-nascido, como aumento das taxas de aborto espontâneo, de natimortos, de restrição de crescimento intrauterino, de morte materna, e de partos prematuros, sobretudo aqueles originados de maneira iatrogênica

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“…1 According to Kobayashi et al, 1 ten deaths were identified, one of which was thought to be causally related to the vaccine, and the other nine maternal deaths had causality C, that is, no causal relationship with the vaccine, and the majority were due to complications inherent in pregnancy, such as pregnancy-specific hypertensive disorder (PSHD) in four cases, and COVID-19 in three. 1 The problem of the efficacy and safety of the COVID-19 vaccine for pregnant women is intriguing, and evidence from real-world situations are needed. 2 Aside from death, there are further concerns about the safety of the COVID-19 vaccine for pregnant women, including the induction of abortion.…”

Section: Dear Editormentioning

confidence: 99%

“…We would like to share ideas on the publication “Adverse Events Related to COVID-19 Vaccines Reported in Pregnant Women in Brazil.” 1 According to Kobayashi et al, 1 ten deaths were identified, one of which was thought to be causally related to the vaccine, and the other nine maternal deaths had causality C, that is, no causal relationship with the vaccine, and the majority were due to complications inherent in pregnancy, such as pregnancy-specific hypertensive disorder (PSHD) in four cases, and COVID-19 in three. 1 The problem of the efficacy and safety of the COVID-19 vaccine for pregnant women is intriguing, and evidence from real-world situations are needed. 2 Aside from death, there are further concerns about the safety of the COVID-19 vaccine for pregnant women, including the induction of abortion.…”

mentioning

confidence: 99%