Adverse health effects due to arsenic exposure: Modification by dietary supplementation of jaggery in mice

Singh, Nutan; Kumar, Deepak; Lal, Kewal; Raisuddin, Sheikh; Sahu, A.P.

doi:10.1016/j.taap.2009.10.014

Cited by 51 publications

(36 citation statements)

References 55 publications

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“…In addition, Kesari et al (2012) observed significant genetic damage in mice exposed to arsenic at the human equivalent reference dose (0.3 μg/kg/day), as well as its multiples (1.5–30 μg/kg/day). Obvious DNA damage was observed in bone marrow cells of mice exposed to arsenic (0.05 and 5 ppm) for 180 days (Singh et al 2010). Exposure to 2.5–5 μM arsenite (about 0.5–1 ppm) could enhance the differentiation of preosteoclastic cells, suggesting that arsenic may result in increased bone resorption (Szymczyk et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of Arsenic on Osteoblast Differentiation in Vitro and on Bone Mineral Density and Microstructure in Rats

Wu¹,

Lu²,

Chan

et al. 2014

Environ Health Perspect

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Background: Arsenic is a ubiquitous toxic element and is known to contaminate drinking water in many countries. Several epidemiological studies have shown that arsenic exposure augments the risk of bone disorders. However, the detailed effect and mechanism of inorganic arsenic on osteoblast differentiation of bone marrow stromal cells and bone loss still remain unclear.Objectives: We investigated the effects and mechanism of arsenic on osteoblast differentiation in vitro and evaluated bone mineral density (BMD) and bone microstructure in rats at doses relevant to human exposure from drinking water.Methods: We used a cell model of rat primary bone marrow stromal cells (BMSCs) and a rat model of long-term exposure with arsenic-contaminated drinking water, and determined bone microstructure and BMD in rats by microcomputed tomography (μCT).Results: We observed significant attenuation of osteoblast differentiation after exposure of BMSCs to arsenic trioxide (0.5 or 1 μM). After arsenic treatment during differentiation, expression of runt-related transcription factor-2 (Runx2), bone morphogenetic protein-2 (BMP-2), and osteocalcin in BMSCs was inhibited and phosphorylation of enhanced extracellular signal-regulated kinase (ERK) was increased. These altered differentiation-related molecules could be reversed by the ERK inhibitor PD98059. Exposure of rats to arsenic trioxide (0.05 or 0.5 ppm) in drinking water for 12 weeks altered BMD and microstructure, decreased Runx2 expression, and increased ERK phosphorylation in bones. In BMSCs isolated from arsenic-treated rats, osteoblast differentiation was inhibited.Conclusions: Our results suggest that arsenic is capable of inhibiting osteoblast differentiation of BMSCs via an ERK-dependent signaling pathway and thus increasing bone loss.Citation: Wu CT, Lu TY, Chan DC, Tsai KS, Yang RS, Liu SH. 2014. Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats. Environ Health Perspect 122:559–565; http://dx.doi.org/10.1289/ehp.1307832

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Section: Discussionmentioning

confidence: 99%

Effects of Arsenic on Osteoblast Differentiation in Vitro and on Bone Mineral Density and Microstructure in Rats

Wu¹,

Lu²,

Chan

et al. 2014

Environ Health Perspect

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“…DNA damage is the stepping stone for the majority of the malignancies and arsenic was proved to induce a number of genetic abnormalities like increase in micronucleus frequency, chromosomal aberrations and DNA damage in rats [5][6][7]. Although it's a major public heath issue, hardly there is any proven therapeutic strategy for chronic arsenic poisoning.…”

Section: Introductionmentioning

confidence: 99%

Protective action of curcumin and nano-curcumin against arsenic-induced genotoxicity in rats in vivo

et al. 2014

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We explored whether nanoformulation of curcumin can cause better protective effect than free curcumin against arsenic-induced genotoxicity. Curcumin-loaded Poly(lactic-co-glycolic acid) nanoparticles (CUR-NP) were prepared by emulsion technique. The CUR-NP were water soluble and showed biphasic release pattern. Rats were divided into 5 groups of 6 each. Group I served as the control. Group II rats were exposed to sodium arsenite (25 ppm) daily through drinking water for 42 days. Groups III, IV and V were maintained as in Group II, however, they were also administered empty nanoparticle, curcumin (100 mg/kg bw) and CUR-NP (100 mg/kg bw), respectively, by oral gavage during the last 14 days of arsenic exposure. On the 43rd day, genotoxic effects were evaluated in bone marrow cells. Arsenic increased chromosomal aberrations, micronuclei formation and DNA damage. Both free curcumin and CUR-NP attenuated these arsenic-mediated genotoxic effects. However, the result suggests that nanoformulation have better protective effect than free curcumin at the same dose level.

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“…Millions of people worldwide are exposed to high concentration of arsenic from groundwater, which the source of drinking water. Arsenic is widely distributed in nature and released into the environment through natural sources, industrial processes and agriculture usage (Singh et al 2010;Chio et al 2009;Chatterjee et al 1995;Mandal et al 1996;Duker et al 2005;Tapio and Grosche 2006). Continued ingestion of arsenic for a long period leads to chronic arsenic poisoning; acute poisoning typically include vomiting, oesophageal and abdominal pain, diarrhoea, skin lesions, cancer of the skin, lungs, urinary bladder, and kidney, as well as other skin changes such as pigmentation changes and thickening (hyperkeratosis), black foot disease (Rahman et al 2005;Atkins et al 2007;Yoshida et al 2004;Chaudhuri et al 2008;Pandey et al 2002;Jack et al 2003;Duker et al 2005;Tseng et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Biosorptive behaviour of mango leaf powder and rice husk for arsenic(III) from aqueous solutions

Kamsonlian

Suresh

Ramanaiah

et al. 2012

Int. J. Environ. Sci. Technol.

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The present study deals with the biosorption of As(III) from aqueous solution using mango leaves powder (MLP) and rice husk (RH) in a batch operation. Scanning electron microscopy and Fourier transformation infrared spectrometry analysis shows the surface texture of biosorbents and metal binding of functional groups of before and after biosorption of As(III). The optimum pH was obtained at 7 and 6 with 7 and 6 g/l of dosage of MLP and RH, respectively. The adsorption of As(III) onto MLP and RH was favourably influenced by an increase in temperature. Equilibrium data were well represented by the Freundlich isotherm model. Nitric acid and ethylenediaminetetra acetic acid was found to be a better eluant for the desorption followed by hydrochloric acid and sodium hydroxide of As(III) with a maximum desorption efficiency of 69.5, 48.5 and 79.4, 86.3 %, respectively. The pseudosecond-order kinetic model was found to best fitted of the experimental data over the equilibrium time at 32 h. The positive values of heat of adsorption (23.89 kJ/mol for MLP and 52.26 kJ/mol for RH) indicate the endothermic nature of the adsorption process. The thermodynamic study showed the spontaneous nature of the sorption of As(III) onto MLP and RH.

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Adverse health effects due to arsenic exposure: Modification by dietary supplementation of jaggery in mice

Cited by 51 publications

References 55 publications

Effects of Arsenic on Osteoblast Differentiation in Vitro and on Bone Mineral Density and Microstructure in Rats

Effects of Arsenic on Osteoblast Differentiation in Vitro and on Bone Mineral Density and Microstructure in Rats

Protective action of curcumin and nano-curcumin against arsenic-induced genotoxicity in rats in vivo

Biosorptive behaviour of mango leaf powder and rice husk for arsenic(III) from aqueous solutions

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