Adverse Immune Reactions to Drugs (Gold, Procainamide) and Environmental Chemicals (Mercury, Platinum): The Role of Phagocytic Cells in Generating Immunogenic Metabolites

Kubicka-Muranyi, Malgorzata; Goebel, Carsten; Griem, Peter; Schuppe, Hans‐Christian; Uetrecht, JackP.; Gleichmann, Ernst

doi:10.1007/978-3-642-78087-5_17

Cited by 6 publications

(2 citation statements)

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“…The Hg was located within dendritic cells similar to those identified and partly phenotyped in experimental, Hg-induced autoimmunity (Warfvinge et al, 1994b). Such local tissue Hg may have an immunoamplifying function (Warfvinge and Larsson, 1994), and this may perhaps also be the case with other metals derived from PFM restorations although no significant findings of silver or gold were made in the present material (Kubicka-Muranyi et al, 1993). The Hg found in some of the biopsies in Groups I1 and I11 probably represents residual Hg from previous amalgam restorations.…”

Section: Histopathology Of Olrsupporting

confidence: 63%

The histopathology of oral mucosal lesions associated with amalgam or porcelain‐fused‐to‐metal restorations

Larsson

Warfvinge

1995

Oral Diseases

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OBJECTIVES: To analyse the interface stomatitis patterns of oral lichenoid lesions in contact with amalgam and to compare these with the histologic changes in oral lesions clinically associated with porcelain-fused-to-metal (PFM) restorations. To relate these features t o the presence of tissue-bound mercury (Hg). DESIGN: A retrospective analysis of tissue biopsies, with clinical data collected via a complementary questionnaire. SUBJECTS AND METHODS: 479 biopsies diagnosed in I987 as 'lichenoid reactions'. From these, we retrieved all with amalgam contact and without candida or medication. From 1990-91, all mucosal lesions stated to be associated with PFM restorations were then retrieved for comparative analysis. The biopsies were examined with routine histologic and autometallographic methods. RESULTS: 77 amalgam-associated lesions were found and could be subdivided into five pre-defined interface stomatitis types. W e found 22 lesions associated with PFM and 20 showed histopathologic features similar to those associated with amalgam. Hg accumulations were detected in the majority of amalgam-associated but only in part of the PFM-associated lesions. CONCLUSIONS: Amalgam-associated lichenoid lesions present a wide spectrum of histopathologic patterns, corresponding to similar patterns in dermatopathology but with no evidence of association with specific disease. PFM-associated lesions tend t o display similar lichenoid features, suggestive of common pathogenetic mechanisms. Hg accumulations may play a role t o maintain the chronicity of such oral lichenoid lesions.Oral lichenoid reactions (OLR) are relatively frequent disorders (Salonen et al, 1990) and it has become increasingly clear that a significant number of them may be associated with metal restorations (Lind et al, 1986;Bolewska et al, 1990a;Henriksson et al, 1995). The pathogenesis of OLR is still unclear although autoimmune, contact allergic and Correspondence: Professor A Larsson,

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Section: Histopathology Of Olrsupporting

confidence: 63%

The histopathology of oral mucosal lesions associated with amalgam or porcelain‐fused‐to‐metal restorations

Larsson

Warfvinge

1995

Oral Diseases

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“…Gold appears to bind directly to major histocompatibility (MHC) class II proteins during antigen presentation; gold contact sensitivity may be more strongly linked to MHC and susceptibility to autoimmune disorders than to atopy [33,34]. Gold-induced nephropathy is linked to HLA-DR3 [35].…”

Section: Metal Allergy In Atopic Dermatitismentioning

confidence: 96%

The role of patch testing for chemical and protein allergens in atopic dermatitis

Nedorost

Cooper

2001

Curr Allergy Asthma Rep

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Many patients who present for evaluation of allergic contact dermatitis have an atopic diathesis. Although the immunologic basis of atopic dermatitis differs from that of allergic contact dermatitis--and patients with atopic dermatitis are less easily sensitized under experimental conditions--atopic patients do develop allergic contact dermatitis, and patch testing is a valuable part of their medical care. Delayed (7-day) patch test readings are especially important in atopic patients to distinguish allergy from irritancy and to evaluate for steroid allergy. The utility of atopy patch tests to aeroallergens such as dust mite is increasingly recognized; aeroallergens may be the cause of a type of protein contact dermatitis.

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Contact stomatitis to mercury associated with spontaneous mononuclear cell infiltrates in Brown Norway (BN) rats with HgCl₂‐induced autoimmunity

Warfvinge¹,

Larsson²

1994

J Oral Pathology Medicine

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Light microscopy and immunocytochemistry have been used to study the tissue reaction to non-irritant concentrations of mercury painted onto the oral mucosa of genetically mercury-sensitive BN rats. Low-dose skin injections of HgCl2 in BN rats result in an autoimmune syndrome, including also a spontaneous migration of T lymphocytes into the oral mucosa. Our results show that such infiltrates confer an increased degree of reactivity (contact stomatitis) to HgCl2 painted onto the BN (Hg) rat oral mucosa. In contrast, results were negative in the LEW rat strain, which is also resistant to development of autoimmunity to skin-injected mercury. The possible involvement of mucosal mercury-loaded macrophages is discussed. The results are also discussed with respect to possible etiologic and pathogenetic mechanisms involved in the development of dental material (amalgam)-associated lichenoid lesions of human oral mucosa.

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Adverse Immune Reactions to Drugs (Gold, Procainamide) and Environmental Chemicals (Mercury, Platinum): The Role of Phagocytic Cells in Generating Immunogenic Metabolites

Cited by 6 publications

References 67 publications

The histopathology of oral mucosal lesions associated with amalgam or porcelain‐fused‐to‐metal restorations

The histopathology of oral mucosal lesions associated with amalgam or porcelain‐fused‐to‐metal restorations

The role of patch testing for chemical and protein allergens in atopic dermatitis

Contact stomatitis to mercury associated with spontaneous mononuclear cell infiltrates in Brown Norway (BN) rats with HgCl₂‐induced autoimmunity

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Adverse Immune Reactions to Drugs (Gold, Procainamide) and Environmental Chemicals (Mercury, Platinum): The Role of Phagocytic Cells in Generating Immunogenic Metabolites

Cited by 6 publications

References 67 publications

The histopathology of oral mucosal lesions associated with amalgam or porcelain‐fused‐to‐metal restorations

The histopathology of oral mucosal lesions associated with amalgam or porcelain‐fused‐to‐metal restorations

The role of patch testing for chemical and protein allergens in atopic dermatitis

Contact stomatitis to mercury associated with spontaneous mononuclear cell infiltrates in Brown Norway (BN) rats with HgCl2‐induced autoimmunity

Contact Info

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Contact stomatitis to mercury associated with spontaneous mononuclear cell infiltrates in Brown Norway (BN) rats with HgCl₂‐induced autoimmunity