Adverse life events and late‐life cognitive decline in a Chinese cohort: The Shanghai Aging Study

Tian, Hongdou; Deng, Wei; Law, Choi Look; Zhao, Qianhua; Liang, Xiaoniu; Wu, Wanqing; Luo, Jianfeng; Ding, Ding

doi:10.1002/gps.5288

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Social interactions and belonging to persons and places cannot easily be measured but it seems to be a promising field of research. Studies on social interactions might be even more necessary given that depression might be associated with the risk of incident cognitive decline among older participants (38). Our results showed that negative relationship events were associated with significant changes in depression, anxiety-and hostility symptoms.…”

Section: Discussionmentioning

confidence: 58%

Threats to Belonging—Stressful Life Events and Mental Health Symptoms in Aging Men—A Longitudinal Cohort Study

et al. 2020

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Objectives: Stressful life events, especially relationship events, are frequent in adult life. We investigated the impact of a variety of stressful life events on symptoms of depression, anxiety, and hostility.Methods: We analyzed data from a large prospective cohort study of men (n = 1,437) in the Boston area (assessed in 1985, 1988, and 1991). Main outcomes were measures of depression, anxiety and hostility symptoms. We used the Elders Life Stress Inventory (ELSI) to measure stressful life events in the past 12 months and examine their association with symptoms of depression, anxiety and hostility. First, we analyzed the association of stressful life events with symptom changes; second, we categorized stressful life events into finance/work, health, relationships, loss, living situations events; and third, we estimated the specific association between relationship events and depression, anxiety and hostility symptoms using multilevel models.Results: The most frequent stressful life events were health, relationship, and financial events. Depression, anxiety, and hostility symptoms were relatively stable among men who did not experience these life events. However, those who reported life events in the past 12 months had a greater increase in symptoms of depression (+0.05; 95% CI: 0.01 to 0.10) and of hostility (+0.05; 95% CI: 0.01 to 0.09) than those who did not. Additionally, we found a significant decrease in hostility (−0.05; 95% CI: −0.08 to −0.01) in those experiencing no life events.Conclusion: Relationship events were more important than any other type of events, and were significantly associated with increased depression and hostility in aging men. Although the effects were small, the results point to a need to understand better the impact of relationships on psychopathology in the aging population.

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Section: Discussionmentioning

confidence: 58%

Threats to Belonging—Stressful Life Events and Mental Health Symptoms in Aging Men—A Longitudinal Cohort Study

et al. 2020

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“…However, other work has challenged the notion that stressful experiences negatively influence cognition. In a longitudinal study of older adults in China, researchers found that nondepressed participants who reported stressful life events had a lower risk of incident dementia than those without stressful experiences (Tian et al., 2020). The authors suggested that the more favorable outcomes observed in the stressor group may reflect resilience and coping skills, which may contribute to preserved cognitive functioning.…”

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confidence: 99%

Posttraumatic stress disorder symptom severity is associated with reduced Montreal Cognitive Assessment scores in a sample of Vietnam War Veterans

Prieto

Moody

Valerio

et al. 2022

Journal of Traumatic Stress

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The goal of the present study was to examine associations between posttraumatic stress disorder (PTSD) symptom severity, the number of stressors experienced, and cognitive outcomes in a sample of U.S. Vietnam War Veterans (N = 274). Adults between 60 and 85 years of age completed a Vietnam Veterans Alzheimer's Disease Neuroimaging Initiative Project visit. A modified version of the Life Stressor Checklist‐Revised (LSC‐R) was used to assess the number of stressful experiences participants experienced, current PTSD severity scores were measured via the Clinician‐Administered PTSD Scale for DSM‐IV (CAPS‐IV), and cognition was assessed using the Montreal Cognitive Assessment (MoCA). Linear regressions were conducted to examine the effect of CAPS‐IV and LSC‐R scores on cognitive performance. Higher CAPS‐IV scores were associated with worse cognitive outcomes on the MoCA, ΔF(1, 264) = 12.686, p < .001, R2 = .142. In contrast, the number of reported stressful experiences was not associated with cognitive outcomes. After accounting for multiple comparisons, findings indicated that CAPS‐IV severity scores were significantly associated with the MoCA memory index. In a sample of older Veterans, PTSD symptom severity, but not the number of reported stressors, was associated with poorer performance on a well‐established cognitive function screening tool. Analyses of specific MoCA domains indicated that memory may be driving this association. These findings suggest that highly arousing stressors characteristic of PTSD, rather than stressful experiences more broadly, contribute to this association. Future work can use these findings to explore whether treating PTSD symptoms may help maintain cognitive function during the aging process.

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“…Some studies have also shown that early‐life adversity has a protective effect on cognitive function 47 . A Chinese prospective study followed up individuals without dementia, but with adverse life events, for a mean of 5.2 years, and showed a significant negative association between life events and the risk of cognitive decline among older adults without depression 27 . To some extent, these contradictory findings in the literature might be due to differences in the study methodologies, study population and sample size.…”

Section: Discussionmentioning

confidence: 99%

“…The Mini‐Mental State Examination (MMSE) 27 and Montreal Cognitive Assessment (Beijing version) 28 were used to evaluate global cognitive function by well‐trained researchers in the present study. The boundary scores of the MMSE were defined as 17 (illiterate), 20 (≤6 years of education), and 24 (>6 years of education) 29 .…”

Section: Methodsmentioning

confidence: 99%

Association of stressful life events with cognitive impairment in patients with type 2 diabetes mellitus

Wang

Dong

Zhao

et al. 2023

J of Diabetes Invest

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Aims/Introduction This study was carried out to investigate the relationship of stressful life events (SLEs) with the risk of cognitive impairment in patients with type 2 diabetes mellitus. Materials and Methods A total of 316 patients with type 2 diabetes mellitus aged >45 years were recruited in this study, and data on demographics, medical history, lifestyle characteristics and SLEs were collected. The cognitive status of patients was evaluated with a battery of cognitive function scales. Logistic regression analyses were carried out to evaluate the risk and protective factors for mild cognitive impairment (MCI). Results Participants, including 217 type 2 diabetes mellitus patients with MCI and 99 patients without MCI, were enrolled in the current study. Among the SLEs, the death of an offspring or parent (odds ratio [OR] 1.994, 95% confidence interval [CI] 1.017–3.908) was a risk factor for MCI after adjustment for age and education level. In the subgroup of participants aged <60 years, the death of an offspring or parent (OR 2.731, 95% CI 1.119–6.665) and financial difficulty (OR 22.205, 95% CI 4.365–112.966) were risk factors for the development of MCI, whereas high working pressure (OR 0.154, 95% CI 0.048–0.495) and career changes (OR 0.324, 95% CI 0.124–0.847) were protective factors for MCI. Conclusions These data suggested that SLEs were associated with cognitive function in patients with type 2 diabetes mellitus. Adverse life events, such as the death of an offspring or parent, were risk factors for cognitive impairment, whereas high work pressure in middle‐aged people was a protective factor against cognitive impairment.

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Adverse life events and late‐life cognitive decline in a Chinese cohort: The Shanghai Aging Study

Cited by 6 publications

References 39 publications

Threats to Belonging—Stressful Life Events and Mental Health Symptoms in Aging Men—A Longitudinal Cohort Study

Threats to Belonging—Stressful Life Events and Mental Health Symptoms in Aging Men—A Longitudinal Cohort Study

Posttraumatic stress disorder symptom severity is associated with reduced Montreal Cognitive Assessment scores in a sample of Vietnam War Veterans

Association of stressful life events with cognitive impairment in patients with type 2 diabetes mellitus

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