Adverse outcomes associated with twin pregnancies conceived via
            <i>in vitro</i>
            fertilization

Gulersen, Moti; Eliner, Yael; Grünebaum, Amos; Lenchner, Erez; Bar-El, Liron; Chervenak, Frank A.; Bornstein, Eran

doi:10.1080/14767058.2022.2122806

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…19 Similarly, Gulersen et al analysed retrospectively 39,356 twin live births and suggested that IVF in twins was associated with increased risk of pre-term birth prior to 28 weeks (aOR = 1.53, 95% CI = 1.43-1.63). 16 In their retrospective cohort study, Saccone et al evaluated 668 diamniotic twin pregnancies (158 IVF and 510 spontaneously conceived) and concluded that IVF-conceived twin pregnancies have a significantly higher risk of spontaneous preterm birth <34 weeks (32,9% vs 21,2%, AOR 1,83, 95% CI 1.03-2.17). 20 Finallly, Okby et al showed that preterm delivery was significantly more common among IVF twins compared to spontaneous twins (OR = 2.14, 95% CI 1.13-4.02, P = 0.016).…”

Section: Preterm Birthmentioning

confidence: 99%

“…13 Finally, a recently published retrospective analysis of the Centers for Disease Control and Prevention agrees with the results of Jiang et al, stating that, after the assessment of 39356 twin pregnancies and after the appropriate adjustment for confounding variables, IVF in twins was associated with a 35% increased risk of gestational diabetes (aOR = 1.35, 95% CI = 1.30-1.39). 16…”

Section: Preterm Birthmentioning

confidence: 99%

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Adverse pregnancy outcomes in twins and their association with the conception method

Rouvali,

Sapantzoglou,

Theodora

et al. 2023

HJOG

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Assisted reproductive technology (ART) has given the opportunity of conception to a large proportion of subfertile women and, at the same time, has led to a substantial increase of multiple pregnancies. Several studies have shown that in vitro fertilization conceived twin pregnancies carry a significant risk of perinatal morbidity and complications. However, it remains unknown whether IVF per se actually increases the risk of pregnancy complications in twin pregnancies or if these should be attributed to the maternal characteristics. In the present review we summarize the findings of published studies related to the most common pregnancy complications encountered in IVF conceived twin pregnancies.

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Section: Preterm Birthmentioning

confidence: 99%

Section: Preterm Birthmentioning

confidence: 99%

Adverse pregnancy outcomes in twins and their association with the conception method

Rouvali,

Sapantzoglou,

Theodora

et al. 2023

HJOG

View full text Add to dashboard Cite

show abstract

“…15 In the same direction, Gulersen et al recently published a large United States population-based cohort study in which 39,356 twin live births were analysed retrospectively and suggested that IVF in twins was associated with an increased risk of hypertensive disorders of pregnancy (aOR = 1.70, 95% CI = 1.65-1.75). 16 Finally, Duy Anh et al in their single-center, retrospective cohort study, investigated 739 dichorionic diamniotic twin pregnancies (483 through IVF/ICSI treatment and 256 spontaneously conceived) and reported that the IVF/ICSI group had significantly higher risks of preeclampsia (aOR: 2.50; 95% CI: 1.12-5.55). 17…”

Section: Hypertensive Disorders In Pregnancymentioning

confidence: 99%

“…19 Similarly, Gulersen et al analysed retrospectively 39,356 twin live births and suggested that IVF in twins was associated with increased risk of preterm birth prior to 28 weeks (aOR = 1.53, 95% CI = 1.43-1.63). 16 In their retrospective cohort study Saccone et al, evaluated 668 diamniotic twin pregnancies (158 IVF and 510 spontaneously conceived) and concluded that IVF-conceived twin pregnancies have a significantly higher risk of spontaneous preterm birth <34 weeks (32,9% vs 21,2%, AOR 1,83, 95% CI 1.03-2.17). 20 Finallly, Okby et al showed that preterm delivery was significantly more common among IVF twins compared to spontaneous twins (OR = 2.14, 95% CI 1.13-4.02, P = 0.016).…”

Section: Preterm Birthmentioning

confidence: 99%

Adverse pregnancy outcomes in twins and their association with the conception method

Rouvali¹,

Sapantzoglou²,

Stavros³

et al. 2022

HJOG

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Comprehensive appraisal of pregnancy and neonatal outcomes in singleton pregnancies conceived via in vitro fertilization in the USA (2016–2021)

Bar-El,

Lenchner,

Gulersen

et al. 2023

Journal of Perinatal Medicine

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Objectives We set out to compare adverse pregnancy and neonatal outcomes in singleton gestations conceived via in vitro fertilization (IVF) to those conceived spontaneously. Methods Retrospective, population-based cohort using the CDC Natality Live Birth database (2016–2021). All singleton births were stratified into two groups: those conceived via IVF, and those conceived spontaneously. The incidence of several adverse pregnancy and neonatal outcomes was compared between the two groups using Pearson’s chi-square test with Bonferroni adjustments. Multivariate logistic regression was used to adjust outcomes for potential confounders. Results Singleton live births conceived by IVF comprised 0.86 % of the cohort (179,987 of 20,930,668). Baseline characteristics varied significantly between the groups. After adjusting for confounding variables, pregnancies conceived via IVF were associated with an increased risk of several adverse pregnancy and neonatal outcomes compared to those conceived spontaneously. The maternal adverse outcomes with the highest risk in IVF pregnancies included maternal transfusion, unplanned hysterectomy, and maternal intensive care unit admission. Increased rates of hypertensive disorder of pregnancy, preterm birth (delivery <37 weeks of gestation), and cesarean delivery were also noted. The highest risk neonatal adverse outcomes associated with IVF included immediate and prolonged ventilation, neonatal seizures, and neonatal intensive care unit admissions, among others. Conclusions Based on this large contemporary United States cohort, the risk of several adverse pregnancy and neonatal outcomes is increased in singleton pregnancies conceived via IVF compared to those conceived spontaneously. Obstetricians should be conscious of these associations while caring for and counseling pregnancies conceived via IVF.

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Adverse outcomes associated with twin pregnancies conceived via in vitro fertilization

Cited by 4 publications

References 22 publications

Adverse pregnancy outcomes in twins and their association with the conception method

Adverse pregnancy outcomes in twins and their association with the conception method

Adverse pregnancy outcomes in twins and their association with the conception method

Comprehensive appraisal of pregnancy and neonatal outcomes in singleton pregnancies conceived via in vitro fertilization in the USA (2016–2021)

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