Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case‐control study

Giorgione, Veronica; Fesslová, Vlasta; Boveri, Sara; Candiani, Massimo; Khalil, Asma; Cavoretto, Paolo

doi:10.1002/pd.5770

Cited by 25 publications

(19 citation statements)

References 31 publications

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“…Separate subanalyses for the singleton and twin pregnancies avoided potential confusion related to twinning. Recent work from our group showed increased rates of placental-related obstetric complications, including preeclampsia, preterm birth and a low-birth weight in relatively large cohorts of CHDs [36,37]. ART pregnancies are also associated with similar complications [3][4][5].…”

Section: Study Strengths and Limitationsmentioning

confidence: 86%

Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study

Galdini

Fesslová

Gaeta

et al. 2021

JCM

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Background and aim of the study: Pregnancies obtained by assisted reproductive technology (ART) are associated with an increased risk of complications and congenital anomalies, particularly congenital heart defects (CHDs). Therefore, our aim is to evaluate, retrospectively, the prevalence of CHD in ART pregnancies in our two centers and analyze their characteristics and outcomes. Methods: Observational study including fetuses conceived by ART referred between June 2011 and September 2020 and undergoing a fetal cardiac ultrasound scan. Cases with genetic, chromosomal abnormalities or extracardiac malformations were excluded. Population included 1511 pregnancies, which consisted of 269 twins and 1242 singletons, 547 IVF (in vitro fertilization), 773 ICSI (intracytoplasmic sperm injection) and 191 oocyte donations (OD). Results: CHDs were found in 29 fetuses, with an overall prevalence of 1.92% (29/1511), 1.85% (23/1242) in singletons and 2.23% in twins (6/269). Thirteen were IVF, eight ICSI and eight OD cases, with a greater risk of CHD after IVF and OD (IVF: 13/29 (44.8%)—one twin; ICSI: 8/29 (27.6%)—three twins); 22 had major and 7 minor defects. Two pregnancies with a hypoplastic left heart were terminated; the majority of live-born cases needed surgery. Three babies died (two post-surgery, one had a late death). Conclusions: Our data show an increased prevalence of CHD after ART with a heterogeneous spectrum of diagnoses, mainly major defects.

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Section: Study Strengths and Limitationsmentioning

confidence: 86%

Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study

Galdini

Fesslová

Gaeta

et al. 2021

JCM

Self Cite

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“…It was interesting to note that there had been statistically significant association between all those factors (except gender) and CHD. The literature supports these findings and shows that there are significant differences in the occurrence of CHD among SGA [ 62 , 63 ], multiple births [ 64 ];, LBW [ 65 ], or preterm birth [ 63 , 66 , 67 ]. Multiple birth status potentially affects intrauterine growth and carries a higher risk of premature birth [ 68 ].…”

Section: Discussionmentioning

confidence: 72%

Maternal sociodemographic characteristics, early pregnancy behaviours, and livebirth outcomes as congenital heart defects risk factors - Northern Ireland 2010-2014

Saad

Sinclair

Bunting

2021

BMC Pregnancy Childbirth

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Background Congenital Heart Defects (CHD) is the most commonly occurring congenital anomaly in Europe and a major paediatric health care concern. Investigations are needed to enable identification of CHD risk factors as studies have given conflicting results. This study aim was to identify maternal sociodemographic characteristics, behaviours, and birth outcomes as risk factors for CHD. This was a population based, data linkage cohort study using anonymised data from Northern Ireland (NI) covering the period 2010-2014. The study cohort composed of 94,067 live births with an outcome of 1162 cases of CHD using the International Statistical Classification of Diseases and Related Health Problems (ICD)-10 codes and based on the European Surveillance of Congenital Anomalies (EUROCAT) grouping system for CHD. CHD cases were obtained from the HeartSuite database (HSD) at the Royal Belfast Hospital for Sick Children (RBHSC), maternal data were extracted from the Northern Ireland Maternity System (NIMATS), and medication data were extracted from the Enhanced Prescribing Database (EPD). STATA version 14 was used for the statistical analysis in this study, Odds Ratio (OR), 95% Confident intervals (CI), P value, and logistic regression were used in the analysis. Ethical approval was granted from the National Health Service (NHS) Research Ethics Committee. Result In this study, a number of potential risk factors were assessed for statistically significant association with CHD, however only certain risk factors demonstrated a statistically significant association with CHD which included: gestational age at first booking (AOR = 1.21; 95% CI = 1.04-1.41; P < 0.05), family history of CHD or congenital abnormalities and syndromes (AOR = 4.14; 95% CI = 2.47-6.96; P < 0.05), woman’s smoking in pregnancy (AOR = 1.22; 95% CI = 1.04-1.43; P < 0.05), preterm birth (AOR = 3.01; 95% CI = 2.44-3.01; P < 0.05), multiple births (AOR = 1.89; 95% CI = 1.58-2.60; P < 0.05), history of abortion (AOR = 1.12; 95% CI = 1.03-1.28; P < 0.05), small for gestational age (SGA) (AOR = 1.44; 95% CI = 1.22-1.78; P < 0.05), and low birth weight (LBW) (AOR = 3.10; 95% CI = 2.22-3.55; P < 0.05). Prescriptions and redemptions of antidiabetic (AOR = 2.68; 95% CI = 1.85-3.98; P < 0.05), antiepileptic (AOR = 1.77; 95% CI = 1.10-2.81; P < 0.05), and dihydrofolate reductase inhibitors (DHFRI) (AOR = 2.13; 95% CI = 1.17-5.85; P < 0.05) in early pregnancy also showed evidence of statistically significant association with CHD. Conclusion The results of this study suggested that there are certain maternal sociodemographic characteristics, behaviours and birth outcomes that are statistically significantly associated with higher risk of CHD. Appropriate prevention policy to target groups with higher risk for CHD may help to reduce CHD prevalence. These results are important for policy makers, obstetricians, cardiologists, paediatricians, midwives and the public.

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“…10 Complication for pregnant women with uncorrected DORV include spontaneous abortion, still birth, IUGR and preterm birth. 11 We also diagnosed IUGR from ultrasonography and after delivery because of Lubchenco score <10%. Hypoxic condition from this patient will cause polycythemia and increase in blood viscosity in the end it will increase the risk of thromboembolism.…”

Section: Resultsmentioning

confidence: 99%

Pregnancy with double outlet right ventricle in university Airlangga hospital Surabaya

Wonodihardjo

Gumilar²,

Akbar³

2021

IJOGR

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Present a case of a successful pregnancy in a patient with Double Outlet Right Ventricle (DORV). A case report of 36 year old pregnant woman with DORV that underwent Cesarean Delivery in University Airlangga Hospital Suurabaya. Participant: A pregnant 36-year-old patient with a DORV. This patient does not aware if she has Cardiac Disease but patient often complaining easy fatigability after doing light work and developed cardiac symptoms, such as dyspnea since 28 weeks Age of Gestation. Once the symptoms developed, patient was referred to Secondary hospital in Bojonegoro, echocardiography was done and patient was diagnosed with DORV. Since DORV is rare case and complicated, after that patient referred to Airlangga Hospital for further evaluation and treatment. Patient was admitted for 9 days, corticosteroid for lung maturity was given and underwent elective C-Section under epidural anesthesia on 34/35 age of gestation. Course in the ward was unremarkable and patient was discharged post operative day 3. This patient was diagnosed with DORV Subaortic Type and underwent cesarean delivery without complication and delivered baby boy without any congenital anomaly from physical examination. The systemic circulation from this patient was balanced until third trimester because the increase of blood volume.

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Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case‐control study

Cited by 25 publications

References 31 publications

Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study

Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study

Maternal sociodemographic characteristics, early pregnancy behaviours, and livebirth outcomes as congenital heart defects risk factors - Northern Ireland 2010-2014

Pregnancy with double outlet right ventricle in university Airlangga hospital Surabaya

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