Adverse reactions associated with simultaneous administration of multiple vaccines to travelers

Falvo, Cathey; Horowitz, Harold W.

doi:10.1007/bf02599650

Cited by 17 publications

(2 citation statements)

References 21 publications

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“…2 Likewise, a person travelling to a diseaseendemic area may accept multiple injections in order to reside under the best possible circumstances. 3 Besides the need for multiple administrations, another issue for vaccine associations is the possibility of interactions between the immune responses. 4 In the best case, association enriches the immune response which may enhance the protective efficacy.…”

Section: Objectivesmentioning

confidence: 99%

Vaccines administered simultaneously: directions for new combination vaccines based on an historical review of the literature

Fletcher¹,

Fabre

Debois

et al. 2004

International Journal of Infectious Diseases

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Based on this historical review, combination vaccines worth reconsideration could fill epidemiologic niches in the EPI with, for instance, a measles--yellow fever, a measles--Japanese encephalitis or a pertussis-based paediatric combination rabies vaccine. Furthermore, other combinations could broaden protection against the pathogens responsible for meningitis, pneumonia, or enteric diseases. Nevertheless, complex issues such as necessity, feasibility, or affordability will ultimately determine if any one of these becomes a combination vaccine.

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Section: Objectivesmentioning

confidence: 99%

Vaccines administered simultaneously: directions for new combination vaccines based on an historical review of the literature

Fletcher¹,

Fabre

Debois

et al. 2004

International Journal of Infectious Diseases

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“…Multiple travel vaccines, such as those against hepatitis A, yellow fever and typhoid are also often co‐administered with no apparent impairment of the immune response to the individual vaccines [17–20]. Research into the tolerability of multiple travel vaccine schedules has suggested that the frequency of adverse side effects, including transient local and systemic reactions may increase with the number of vaccinations, but that these side effects are generally mild [17,21,22]. In all cases, the advantages of multiple vaccination must outweigh the possible concerns over variation in responses to the individual antigen components.…”

Section: Introductionmentioning

confidence: 99%

Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine

Griffin

Bedford

Townson

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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Vaccines against bioterrorism agents offer the prospect of providing high levels of protection against airborne pathogens. However, the diversity of the bioterrorism threat means that it may be necessary to use several vaccines simultaneously. In this study we have investigated whether there are changes to the protective immune response to a recombinant sub-unit plague vaccine when it is co-administered with other sub-unit or live attenuated vaccines. Our results indicate that the co-administration of these vaccines did not influence the protection afforded by the plague vaccine. However, the co-administration of the plague sub-unit vaccine with a live vaccine resulted in markedly increased levels of IgG2a subclass antibodies, and markedly reduced levels of IgG1 subclass antibodies, to the plague sub-unit vaccine. This finding might have implications when considering the co-administration of other vaccine combinations.

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Development and evaluation of a standardized questionnaire for identifying adverse events in vaccine clinical trials

Coplan

Chiacchierini

Nikas

et al. 2000

Pharmacoepidem. Drug Safe.

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In vaccine trials, diary questionnaires or vaccination report cards (VRCs) are used extensively to collect complaints reported by subjects or guardians following vaccination. These have not been evaluated for accuracy or standardized to facilitate tolerability comparisons among vaccines. Objectives —(1) Develop standardized, age‐specific VRCs for collecting self‐reported adverse events (AEs) in trials; (2) Evaluate whether complaints elicited by nurse examinations or telephone interviews were missed by VRCs. Methods —Vaccine‐trial databases, focus groups, experts and experienced nurses were used to develop paediatric and adolescent/adult VRCs. VRCs were evaluated at four sites. The primary outcome was subjects with AEs missed on the VRC and reported in nurse examinations (for injection‐site reactions) or telephone interviews (for systemic complaints). Results —Of 855 subjects, 96.5% completed VRCs. For systemic complaints, 1.5% (12/812) reported both no complaint on VRCs and at least one complaint in telephone interviews. For injection‐site reactions, 5.1% (53/1030) of injection sites had both no reaction reported on VRCs and had reactions noted by nurse examination. No missed AEs were rated as severe. Conclusion —The data suggest VRCs provide a practical and reasonably complete method of eliciting complaints following vaccination. Copyright © 2000 John Wiley & Sons, Ltd.

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Adverse reactions associated with simultaneous administration of multiple vaccines to travelers

Abstract: Side effects for vaccination of travelers are common. Increasing the number of vaccines is associated with increasing the rates of local and systemic reactions. These reactions are generally minor and should not be a reason to withhold multiple vaccinations to patients when needed.

Cited by 17 publications

References 21 publications

Vaccines administered simultaneously: directions for new combination vaccines based on an historical review of the literature

Vaccines administered simultaneously: directions for new combination vaccines based on an historical review of the literature

Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine

Development and evaluation of a standardized questionnaire for identifying adverse events in vaccine clinical trials

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