Adverse reactions from consumption of oral rabies vaccine baits in dogs in Finland

Nokireki, Tiina; Nevalainen, Martti; Sihvonen, Liisa; Gadd, Tuija

doi:10.1186/s13028-016-0234-3

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…However, 42.86% of all dogs swallowed the same capsule during the field study in the Navajo Nation [ 15 ]. Swallowing the PVC-capsule should be avoided since it can cause problems like gastric intolerance in the dogs [ 23 ]. However, such adverse events were not reported with the same PVC-capsule during the study in the Navajo Nation and another field trial in Haiti [ 15 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Field Studies Evaluating Bait Acceptance and Handling by Free-Roaming Dogs in Thailand

Kasemsuwan

Chanachai²,

Pinyopummintr

et al. 2018

Veterinary Sciences

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(1) Background: As part of the ongoing endeavor to eliminate dog-mediated human rabies in Thailand, renewed interest has been shown in oral vaccination of dogs as a supplementary tool to increase vaccination coverage of the dog population. (2) Methods: Three different bait types were tested using a hand-out model on the campus of the Kasetsart University and the surrounding temples in Thailand during September 2017, consisting of two industrial manufactured baits (fish meal and egg-flavored) and one bait made from local material (boiled pig intestine placed in collagen casing). A PVC-capsule containing dyed water was inserted in the bait. (3) Results: The fishmeal bait was significantly less often accepted and consumed (50.29%) than the other two baits (intestine bait—79.19%; egg bait—78.77%). Delivery and release of the dyed water in the oral cavity was highest in the egg-flavored bait (84.50%), followed by the intestine bait (76.61%) and fishmeal (54.85%) baits. Bait acceptance was influenced by sex, age, and body size of the dog. Also, the origin of the dogs had a significant effect: temple dogs accepted the baits more often than street dogs. (4) Conclusion: A significant portion of the free-roaming dog population in this study can be vaccinated by offering vaccine baits.

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Section: Discussionmentioning

confidence: 99%

Field Studies Evaluating Bait Acceptance and Handling by Free-Roaming Dogs in Thailand

Kasemsuwan

Chanachai²,

Pinyopummintr

et al. 2018

Veterinary Sciences

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“…During previous screening trials in the study area it was observed that the sachets, PVC-capsules sealed (‘hard blister’) with aluminum foil, used in the Navajo Nation and Thailand were often swallowed [35]. It was decided to replace these sachets for this trial with a sachet made from biodegradable foil covered with a fleece that can absorb fluids; ‘soft blister’ (70 × 35 × 5 mm).…”

Section: Methodsmentioning

confidence: 99%

Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India

Gibson

Mazeri

Yale³

et al. 2019

TropicalMed

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Introduction: To achieve the global goal of canine-mediated human rabies elimination by 2030 there is an urgent need to scale-up mass dog vaccination activities in regions with large dog populations that are difficult to access; a common situation in much of India. Oral rabies vaccination may enable the vaccination of free-roaming dogs that are inaccessible to parenteral vaccination, and is considered a promising complementary measure to parenteral mass dog vaccination campaigns. WHO and OIE have published detailed minimum requirements for rabies vaccines and baits to be used for this purpose, requiring that baits must not only be well-accepted by the target population but must also efficiently release the vaccine in the oral cavity. For oral rabies vaccination approaches to be successful, it is necessary to develop baits which have a high uptake by the target population, are culturally accepted and amenable to mass production. The aim of this study was to compare the interest and uptake rates of meat-based and an egg-based prototype bait constructs by free roaming dogs in Goa, India. Methods: Three teams randomly distributed two prototype baits; an egg-flavoured bait and a commercial meat dog food (gravy) flavoured bait. The outcomes of consumption were recorded and compared between baits and dog variables. Results: A total of 209 egg-bait and 195 gravy-bait distributions were recorded and analysed. No difference (p = 0.99) was found in the percentage of dogs interested in the baits when offered. However, significantly more dogs consumed the egg-bait than the gravy-bait; 77.5% versus 68.7% (p = 0.04). The release of the blue-dyed water inside the sachet in the oral cavity of the animals was significant higher in the dogs consuming an egg-bait compared to the gravy-bait (73.4% versus 56.7%, p = 0.001). Conclusions: The egg-based bait had a high uptake amongst free roaming dogs and also enabled efficient release of the vaccine in the oral cavity, whilst also avoiding culturally relevant materials of bovine or porcine meat products.

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“…During the oral rabies vaccination campaigns in Finland from 2011 to 2014, 160 000 to 360 000 SAG2 vaccine baits were distributed annually. There were nine reports from dog owners or veterinarians about dogs experiencing signs associated with the consumption of SAG2 baits during hunting [ 38 ]. Reported gastrointestinal signs (e.g., vomiting, inappetence, constipation or diarrhea) were probably related to the ingestion of the aluminium/polyvinyl chloride sachet and behavioral signs (e.g., restlessness, listlessness and unwillingness to continue hunting) were probably related to the discomfort caused by the ingestion of multiple baits [ 38 ].…”

Section: Safetymentioning

confidence: 99%

Oral vaccination of dogs: a well-studied and undervalued tool for achieving human and dog rabies elimination

Cliquet

Guiot²,

Aubert³

et al. 2018

Vet Res

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The mass vaccination of dogs is a proven tool for rabies prevention. Besides parenteral delivery of inactivated vaccines, over the past several decades, several self-replicating biologics, including modified-live, attenuated and recombinant viruses, have been evaluated for the oral vaccination of dogs against rabies. Vaccines are included within an attractive bait for oral consumption by free-ranging dogs. Due to the high affinity between dogs and humans, such biologics intended for oral vaccination of dogs (OVD) need to be efficacious as well as safe. Baits should be preferentially attractive to dogs and not to non-target species. Although many different types have been evaluated successfully, no universal bait has been identified to date. Moreover, high bait acceptance does not necessarily mean that vaccine efficacy and programmatic success is predictable. The use of OVD in the laboratory and field has demonstrated the safety and utility of this technology. Within a One Health context, OVD should be considered as part of a holistic plan for the global elimination of canine rabies.Electronic supplementary materialThe online version of this article (10.1186/s13567-018-0554-6) contains supplementary material, which is available to authorized users.

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Adverse reactions from consumption of oral rabies vaccine baits in dogs in Finland

Cited by 9 publications

References 7 publications

Field Studies Evaluating Bait Acceptance and Handling by Free-Roaming Dogs in Thailand

Field Studies Evaluating Bait Acceptance and Handling by Free-Roaming Dogs in Thailand

Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India

Oral vaccination of dogs: a well-studied and undervalued tool for achieving human and dog rabies elimination

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