Adverse reactions of vancomycin in humans

Yang, Peng; Li, Chenyang; Yang, Zhi‐Ling; Shi, Wei

doi:10.1097/md.0000000000022376

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Vancomycin infusion through the PVC also had an impact on the occurrence of local complications, as already reported (Sorrell & Collignon, 1985); the results of an ongoing meta-analysis on adverse reactions to vancomycin may help corroborate or refute this finding (Peng et al, 2020). Other antibiotics also increased the risk of local PVC complications, as reported previously for dicloxacillin, cloxacillin, erythromycin and cefuroxime (Lanbeck et al, 2002).…”

Section: Discussionsupporting

confidence: 69%

Incidence of and risk factors for local complications of peripheral venous catheters in patients older than 70 years: Empirical research quantitative

Gras,

Jean,

Rocher

et al. 2023

Journal of Clinical Nursing

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Section: Discussionsupporting

confidence: 69%

Incidence of and risk factors for local complications of peripheral venous catheters in patients older than 70 years: Empirical research quantitative

Gras,

Jean,

Rocher

et al. 2023

Journal of Clinical Nursing

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“…Sodium valproate, vancomycin, and linezolid are the common drugs associated with DILI[ 5 , 7 , 8 ]. Among all the adverse reactions of vancomycin, most are rapid onset, and renal injury occurs more frequently than liver injury[ 9 ]. Common adverse reactions of linezolid include myelotoxicity and peripheral and optic neuropathy[ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report

Mei¹,

Wu²,

Ruan³

et al. 2021

WJCC

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BACKGROUND Sodium valproate is widely used in the treatment of epilepsy in clinical practice. Most adverse reactions to sodium valproate are mild and reversible, while serious idiosyncratic side effects are becoming apparent, particularly hepatotoxicity. Herein, we report a case of fatal acute liver failure (ALF) with thrombotic microangiopathy (TMA) caused by treatment with sodium valproate in a patient following surgery for meningioma. CASE SUMMARY A 42-year-old man who received antiepileptic treatment with sodium valproate after surgery for meningioma exhibited extreme fatigue, severe jaundice accompanied by oliguria, soy sauce-colored urine, and ecchymosis. His postoperative laboratory values indicated a rapid decreased platelet count and hemoglobin level, severe liver and kidney dysfunction, and disturbance of the coagulation system. He was diagnosed with drug-induced liver failure combined with TMA. After plasma exchange combined with hemoperfusion, pulse therapy with high-dose methylprednisolone, and blood transfusion, his liver function deteriorated, and finally, he died. CONCLUSION ALF with TMA is a rare and fatal adverse reaction of sodium valproate which needs to be highly valued.

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“…However, severe diarrhea, hearing loss, angioedema, neutropenia, nephrotoxicity, ototoxicity, and Van flushing syndrome (VFS, with quite varying incidences, were reported as non-negligible adverse effects of this antibiotic. These adverse effects strongly concern patients with diabetes, renal impairment, and hypersensitivity [ 35 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl Chitosan Microgels for Sustained Delivery of Vancomycin and Long-Lasting Antibacterial Effects

Sahiner,

Yilmaz,

Ayyala

et al. 2023

Gels

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Carboxymethyl chitosan (CMCh) is a unique polysaccharide with functional groups that can develop positive and negative charges due to the abundant numbers of amine and carboxylic acid groups. CMCh is widely used in different areas due to its excellent biocompatibility, biodegradability, water solubility, and chelating ability. CMCh microgels were synthesized in a microemulsion environment using divinyl sulfone (DVS) as a crosslinking agent. CMCh microgel with tailored size and zeta potential values were obtained in a single stem by crosslinking CMCh in a water-in-oil environment. The spherical microgel structure is confirmed by SEM analysis. The sizes of CMCh microgels varied from one micrometer to tens of micrometers. The isoelectric point of CMCh microgels was determined as pH 4.4. Biocompatibility of CMCh microgels was verified on L929 fibroblasts with 96.5 ± 1.5% cell viability at 1 mg/mL concentration. The drug-carrying abilities of CMCh microgels were evaluated by loading Vancomycin (Van) antibiotic as a model drug. Furthermore, the antibacterial activity efficiency of Van-loaded CMCh microgels (Van@CMCh) was investigated. The MIC values of the released drug from Van@CMCh microgels were found to be 68.6 and 7.95 µg/mL against E. coli and S. aureus, respectively, at 24 h contact time. Disk diffusion tests confirmed that Van@CMCh microgels, especially for Gram-positive (S. aureus) bacteria, revealed long-lasting inhibitory effects on bacteria growth up to 72 h.

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Adverse reactions of vancomycin in humans

Cited by 9 publications

References 22 publications

Incidence of and risk factors for local complications of peripheral venous catheters in patients older than 70 years: Empirical research quantitative

Incidence of and risk factors for local complications of peripheral venous catheters in patients older than 70 years: Empirical research quantitative

Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report

Carboxymethyl Chitosan Microgels for Sustained Delivery of Vancomycin and Long-Lasting Antibacterial Effects

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