Adverse Reactions Reporting and Age

Hopf, G; Mathias, B

doi:10.1016/s0140-6736(88)90100-6

Cited by 8 publications

(8 citation statements)

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“…Unexpectedly, slightly more ADR reports referred to older males than females when related to either 100,000 inhabitants or assumed drug-exposed inhabitants in our analysis. With regard to gender related differences concerning ADRs in older adults there is conflicting data in literature [15,17,44,[53][54][55]. Different study designs (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices

Dubrall

Just

Schmid

et al. 2020

BMC Pharmacol Toxicol

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Background: Older adults are more prone to develop adverse drug reactions (ADRs) since they exhibit numerous risk factors. The first aim was to analyse the number of spontaneous ADR reports regarding older adults (> 65) in the ADR database of the German Federal Institute for Drugs and Medical Devices (BfArM) and to set them in relation to i) the number of ADR reports concerning younger adults (19-65), and ii) the number of inhabitants and assumed drug-exposed inhabitants. The second aim was to analyse, if reported characteristics occurred more often in older vs. younger adults. Methods: All spontaneous ADR reports involving older or younger adults within the period 01/01/2000-10/31/2017 were identified in the ADR database. Ratios concerning the number of ADR reports/number of inhabitants and ADR reports/drug-exposed inhabitants were calculated. The reports for older (n = 69,914) and younger adults (n = 111, 463) were compared using descriptive and inferential statistics. Results: The absolute number of ADR reports involving older adults increased from 1615 (2000) up to 5367 ADR reports (2016). The age groups 76-84 and 70-79 had the highest number of ADR reports with 25 ADR reports per 100,000 inhabitants and 27 ADR reports per 100,000 assumed drug-exposed inhabitants. For both ratios, the number of reports was higher for males (26 and 28 ADR reports) than for females (24 and 26 ADR reports). Fatal outcome was reported almost three times more often in older vs. younger adults. Six out of ten drug substances most frequently suspected were antithrombotics (vs. 1/10 in younger adults). For some drug substances (e.g. rivaroxaban) the ADRs reported most frequently differed between older (epistaxis) and younger adults (menorrhagia).

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Section: Discussionmentioning

confidence: 99%

“…Therefore, the causal association with drug treatment is difficult to assess [10,14] and the prevalence of ADRs in older adults might even be higher. With regard to the reporting of ADRs, some (older) studies found that ADRs in older adults are less often reported [15,16] whereas a recent study describes the opposite [17].…”

Section: Introductionmentioning

confidence: 99%

Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices

Dubrall

Just

Schmid

et al. 2020

BMC Pharmacol Toxicol

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“…To our knowledge, there are only a few studies in the literature which consider overall reporting of spontaneous ICSRs in relation to dispensed drugs, on a national basis. 20,[28][29][30] Stratification for seriousness is only performed in one of them. 30 Others have studied these issues based on a sample of selected drugs 19,31,32 or based on regional data.…”

Section: Discussionmentioning

confidence: 99%

Influence of age, sex and seriousness on reporting of adverse drug reactions in Sweden

Holm

Ekman

Blomgren

2017

Pharmacoepidemiology and Drug

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“…The link between polypharmacy, age, and hospital admission caused by ADRs has been mentioned in many of the studies reviewed in section 2 (Bergman & Wilholm 1981;Caranasos et al 1974;Colt & Shapiro 1989;Levy et al 1980;Williamson & Chopin 1980). Attempts have been made to control for polypharmacy in studies which have analysed spontaneously reported data (Hopf & Mathias 1988;Tanner & Baum 1988;). When the number of prescribed drugs has been allowed for, the role of age as a determinant of ADR is less certain than has previously been believed.…”

Section: Polypharmacymentioning

confidence: 99%

Adverse Reactions as a Cause of Hospital Admission in the Aged

Beard

1992

Drugs & Aging

118

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Truly elderly people comprise an increasingly large fraction of the population and consume a disproportionate amount of drugs. Over the last 25 years a number of different studies have illustrated that advancing age is associated with adverse drug reactions (ADRs). Advancing age is also associated with polypharmacy and multiple pathology, and this complex inter-relationship makes it difficult to conclude that age itself is a causative factor for ADRs. ADRs resulting in hospital admission have been the subject of study for many years, but it has not been consistently demonstrated that advancing age is a predisposing factor. Early studies used the method of intensive inpatient monitoring and identified digoxin, diuretics, aspirin, psychotropics and cytotoxics as drugs of concern. Smaller more recent studies have used more sophisticated statistical techniques to identify predisposing factors. Nonsteroidal anti-inflammatory drugs have been added to the list of drugs that may cause ADR-related hospital admission. Polypharmacy, and altered pharmacokinetics and pharmacodynamics are possible causative factors; however, variable compliance and multiple pathology may cause difficulties with attributing causality. Some basic guidelines for sensible prescribing would almost certainly result in fewer ADRs in the elderly, including those ADRs severe enough to result in hospital admission.

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Adverse Reactions Reporting and Age

Cited by 8 publications

References 0 publications

Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices

Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices

Influence of age, sex and seriousness on reporting of adverse drug reactions in Sweden

Adverse Reactions as a Cause of Hospital Admission in the Aged

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