1989
DOI: 10.1016/s0140-6736(89)91421-9
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Adverse Reactions to Carbamazepine Managed by Desensitisation

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Cited by 26 publications
(15 citation statements)
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“…Recently, Vick [18], Murphy et al [12] and Hampton et al [6] reported the use of prednisone to suppress the CBZ-induced rash. Also, Smith and Newton [17] and Eames [2] successfully re-introduced CBZ without steroids in patients with a prior allergic response, using very small doses that were gradually increased over several months. But not all cases with a rash can be safely managed using these methods [6,12], so we recommend these approaches only in patients with refractory seizures or in those with multiple anticonvulsant intolerance.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Vick [18], Murphy et al [12] and Hampton et al [6] reported the use of prednisone to suppress the CBZ-induced rash. Also, Smith and Newton [17] and Eames [2] successfully re-introduced CBZ without steroids in patients with a prior allergic response, using very small doses that were gradually increased over several months. But not all cases with a rash can be safely managed using these methods [6,12], so we recommend these approaches only in patients with refractory seizures or in those with multiple anticonvulsant intolerance.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, studies of desensitization to AEDs are rare, though several case reports about desensitization to a small number of aromatic AEDs have been published. These reports include cases of successful desensitization to carbamazepine in patients who are intolerant to multiple AEDs, and to pentobarbital in an infant with Ohtahara syndrome 131920. Itomi et al21 reported the occurrence of desensitization to phenytoin in an 8-year-old boy with intractable complex partial seizures.…”
Section: Discussionmentioning
confidence: 99%
“…AED-induced cutaneous adverse reactions reportedly occur in 5–17% of epilepsy patients,11 but there is a lack of literature describing desensitization to AEDs, with most of the existing literature consisting of case reports 121314. We have previously reported on a pilot study of the efficacy of desensitization to oxcarbazepine,15 but no previous study has demonstrated the ongoing effectiveness and safety of desensitization to oxcarbazepine.…”
Section: Introductionmentioning
confidence: 99%
“…The slow up-titration regimen, implemented by Besag et al (2000), mentioned in Table 2 had a 100 % success rate in children. Other authors (Eames, 1989;Smith and Newton, 1985) have also suggested that such slow titration desensitization regimes might be used to prevent rash developing with carbamazepine.…”
Section: Discussionmentioning
confidence: 99%