Adverse Reactions to Fluorescein Angiography

Abstract

Adverse reactions to ophthalmic patients during 9909 fluorescein angiographies during 9 years were registered. Nausea (4.6%) and vomiting (1.3%) wem the most common untoward reactions. Allergic skin manifestations occurred in 48 patients, and 5 patients coniplained of shortness of breath. 56 patients (0.6%) felt dixy during or immediately after the investigation. Nine patients complained of chest pain, three of whom developed myocardial infarction.Sixteen patients collapsed during the procedure. One healthy male, 42-year-old, collapsed after the injection of fluorescein during angiography, and electrocardiogram showed an asystole of 24 seconds. Otherwise, the electrocardiograms registered on 100 consecutive patients did not reveal any systematic changes in heart rate or rhythm during fluorescein angiography.

Adverse reactions of fluorescein angiography: a prospective study

“…However, the report of adverse reactions is rare. In case of oral administration of fluorescein, the frequency of reactions is between 1% and 2% (14)(15)(16) and in case of intravenous dye it is between 3% and 20% (4)(5)(6)(7)(8)(17)(18) . In this study, the cumulative incidence of adverse reactions to dye injection was 9.72% in patients who were submitted to fluorescein angiography for the first time.…”

“…These are divided into mild (nausea, vomiting, pruritus, sneezing, vaso-vagal disorders, inadvertent arterial injection), moderate (urticaria, other skin eruptions, syncope, thrombophlebitis, pyrexia, local tissue necrosis, muscular paralysis) and severe (bronchospasm, laryngeal edema, circulatory shock, myocardial infarction, tonic-clonic seizure) (5)(6)(7) . Previous studies indicate that the most frequent adverse reactions are mild, such as nauseas and vomiting (2% to 14%) and that moderate and severe reactions are infrequent (<1%) (5)(6)8) . The reported frequency of these adverse reactions has varied among authors, however most of the studies are retrospective and they do not distinguish patients who had previously undergone this test from those who had undergone it for the first time (7,(9)(10) .…”

“…Retinal complications of hypertensive and diabetic retinopathy are the main diseases that motivate request for this test (11)(12) . Some authors report that allergy history, systemic arterial hypertension (SAH) and diabetes increase the risk of adverse reactions to fluorescein injection (8)(9) . The purposes of this prospective study are both to determine the incidence of adverse reactions in patients who had undergone fluorescein angiography for the first time, and to determine if SAH, diabetes or allergy history increase the chance of reaction to intravenous fluorescein.…”

Eye-motion-corrected optical coherence tomography angiography using Lissajous scanning

“…The most commonly used angiography methods include fluorescein angiography (FA) [1] and indocyanine green angiography (ICGA) [2]. However, these angiography methods are invasive and require dye injection into the human body, which can occasionally have adverse effects [3][4][5][6].…”

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

“…It allows sequential visualization of the blood flow simultaneously in the retina, choroid and iris, and it gives diagnostic support to clinical impressions based on alterations in fluid dynamics resulting from ocular disease processes (1)(2) . This procedure is considered relatively safe and although numerous adverse reactions have been reported in literature, the most frequent are mild, such as nausea and vomiting (3)(4)(5) . The incidence of these adverse reactions has varied among the authors (2%-14%) (6)(7)(8) .…”