Adverse Reactions to Meprobamate

Friedman, Henry T.

doi:10.1001/jama.1956.02970240010004

Cited by 36 publications

(2 citation statements)

References 3 publications

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“…Other reports have been published, however, indicating that the drug has some degree of allergic potency. Rashes have been reported by McGee ( 122), Stroud ( 164) , and Friedman and Marmelgat (65); purpura, thrombocytopenic, reported by Bernstein and Klotz ( 2 0 ) ; and nonthrombocytopenic by Carmel and Dannenberg ( 3 2 ) . Urticaria was noted by Bernstein and Klotz (zo), Carmel and Dannenberg ( 3 2 ) , and Kositchek ( 106).…”

Section: O T H E R D R U G Smentioning

confidence: 90%

The tranquilizing drugs.

Freeman¹

1958

Schizophrenia: A Review of the Syndrome.

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Section: O T H E R D R U G Smentioning

confidence: 90%

The tranquilizing drugs.

Freeman¹

1958

Schizophrenia: A Review of the Syndrome.

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“…Allergic rashes respond to drug withdrawal or concomitant use of antihistaminic medication. More severe form of skin reactions, like pustular skin lesions and purpura, have also been reported (Friedman et al, 1956;. These promptly respond to discontinuation of the drug and corticosteroid therapy (Stroud, 1957).…”

Section: Meprobamate Side Effects Abuse and Withdrawalmentioning

confidence: 99%

Assessment of molecular action of direct gating and allosteric modulatory effects of carisoprodol (SomaRTM) on GABA A receptors

Kumar¹

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Meprobamate (tradenames Miltown, Equanil) is a schedule IV anxiolytic and the primary metabolite of the muscle relaxant carisoprodol. Meprobamate modulates GABAA (aminobutyric acid type A) receptors, and has been described as having barbiturate-like activity. A thorough understanding of its mechanism remains ill-defined, however. To gain insight into its actions, we have conducted a series of studies using recombinant GABAA receptors. In xz GABAA receptors (where x = 1-6 and z = 1-3), the ability to enhance GABA-mediated current was evident for all  subunit isoforms, with the largest effect observed in 5-expressing receptors. Direct gating was comparable with all  subunits, although the effect was attenuated in α3-expressing receptors. Allosteric potentiating and direct gating effects were comparable in 112 and 122 receptors, whereas allosteric effects were enhanced in 12 compared to 122 receptors. In "extrasynaptic" GABAA receptors (α1β3δ and α4β3δ receptors), meprobamate allosterically enhanced both EC20 and saturating GABA currents, and directly activated these receptors with an efficacy comparable to that of GABA. Bemegride, which antagonizes effects of pentobarbital, attenuated direct gating effects of meprobamate. Whereas pentobarbital directly gated homomeric β3 receptors, meprobamate did not, and instead blocked the spontaneously open current present in these receptors. In wild type homomeric ρ1 DEDICATION I dedicate my dissertation to my mother Mrs. Manju Kumari whose tireless patience and encouragement helped me in toughest of the times. My Grand Father, Late Mr. Awadh Kishore Das. My aunt Bindu Kumari, whose first words when I joined medical school was, "win a Nobel prize in medicine". My father, Mr. Sachchidanand Roy, who stood behind me through thick and thin and last but not the least, my mentor Dr. Glenn H. Dillon. v ACKNOWLEDGMENTS I would like to thank these important people who have helped and guided me in achieving my goals. Dr. Glenn H. Dillon: An excellent mentor, excellent scientist, excellent administrator, excellent family man and an amazing person. I am extremely lucky to have you as mentor for not only learning science but every moment spent with you was a learning experience. So, Thank you. Dawn Dillon: An amazing person, who did not let us miss our family away from home. Thank you.

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An Evaluation of Meprobamate in the Management of Selected Dermatoses

Becker¹

1958

Arch Dermatol

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Adverse Reactions to Meprobamate

Cited by 36 publications

References 3 publications

The tranquilizing drugs.

The tranquilizing drugs.

Assessment of molecular action of direct gating and allosteric modulatory effects of carisoprodol (SomaRTM) on GABA A receptors

An Evaluation of Meprobamate in the Management of Selected Dermatoses

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