Adverse reactions to nonsteroidal anti-inflammatory drugs and hypersensitivity to lipid transfer proteins

Nucera, Eleonora; Rienzo, Alessia Di; Ricci, Anna Giulia; Buonomo, Alessandro; Mezzacappa, Simona; Schiavino, Domenico

doi:10.5114/ada.2016.61608

Cited by 7 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 Another interesting aspect is the frequent association between LTP hypersensitivity and adverse reactions to non-steroidal anti-inflammatory drugs (NSAIDs). [33][34][35][36] It was recently shown that NSAIDs are able to enhance IgE-mediated activation of basophils, an effect that can be essential for the occurrence of severe reactions in patients who are only slightly sensitized to certain foods. 37 Along with negative co-factors, "positive" co-factors exist as well.…”

Section: Th E Relevance Of Co-factors In Ltp Hypersensitivitymentioning

confidence: 99%

“…LTP is the most frequent sensitizer in Italians with food‐dependent exercise‐induced anaphylaxis . Another interesting aspect is the frequent association between LTP hypersensitivity and adverse reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs) . It was recently shown that NSAIDs are able to enhance IgE‐mediated activation of basophils, an effect that can be essential for the occurrence of severe reactions in patients who are only slightly sensitized to certain foods …”

Section: The Relevance Of Co‐factors In Ltp Hypersensitivitymentioning

confidence: 99%

See 1 more Smart Citation

The clinical relevance of lipid transfer protein

Asero

Piantanida

Pinter

et al. 2017

Clin Experimental Allergy

View full text Add to dashboard Cite

SummaryDespite a huge number of studies, many aspects of the lipid transfer protein (LTP) syndrome, the most frequent primary food allergy in Mediterranean countries, remain unclear. Its peculiar geographical distribution, along with the extreme variability of its clinical expression, makes this type of food allergy something unique in the panorama of IgE-mediated food-induced allergic reactions. This review article tried to summarize the current knowledge about the most important aspects of LTP sensitization and allergy, along with the importance of positive and negative co-factors in the clinical expression of the syndrome as well as the issues regarding the cross-reactivity between LTPs present in botanically related and unrelated foods.Further, the possible absence of the protein from some plant foods is discussed.anaphylaxis, food allergy, lipid transfer protein, oral allergy syndrome

show abstract

Section: Th E Relevance Of Co-factors In Ltp Hypersensitivitymentioning

confidence: 99%

Section: The Relevance Of Co‐factors In Ltp Hypersensitivitymentioning

confidence: 99%

The clinical relevance of lipid transfer protein

Asero

Piantanida

Pinter

et al. 2017

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…The characterization of the population studied shows that in our area, LTP is the main responsible/elicitor of FDNIH, with gliadin following far behind. The key role played by LTP in our patients is in line with previous studies that have shown the high prevalence of plant food allergy associated with NSAIDs as cofactors in the Mediterranean area, [21][22][23] but contrasts with other articles where gliadin is the most frequent responsible allergen. 20,26,27 The systematic use of both SPT and sIgE to Pru p 3 (LTP) and Tri a 19 (gliadin) in our study showed that both methods are similarly valid in the detection of these sensitizations.…”

Section: Discussionmentioning

confidence: 99%

“…Although the LTP syndrome (considered when an LTP‐sensitized patient displays reactivity to several taxonomically unrelated plant foods containing LTP) has rarely been reported in patients from other geographical regions, recent studies have shown that the prevalence of patients diagnosed with LTP syndrome is much higher than previously reported, when the Pru p 3 is systematically included in the workup of patients with history of food‐induced allergic reactions 29–36 . The spectrum of food allergens involved in FDNIH may vary depending on the ecological characteristics and dietary habits of the studied populations 19–29 . Moreover, the potential implication in FDNIH of other predominant pan‐allergens, such as profilins or PR‐10, frequently present in other geographical areas, should not be overlooked.…”

Section: Discussionmentioning

confidence: 99%

“…NSAID intake has been reported to be present in up to 22% of food‐induced anaphylactic shocks, representing a risk factor with an odds ratio higher than 11 19 . In some FDNIH reactions, NSAID is the only co‐factor required to trigger or enhance the symptoms, such as urticaria or anaphylaxis 20–26 . The spectrum of foods involved in FDNIH is wide (wheat, nuts, seeds, vegetables, shellfish, peanut), 19–29 highlighting wheat, plant foods, and shellfish as the most prevalent foods involved.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Food‐dependent NSAID‐induced hypersensitivity (FDNIH) reactions: Unraveling the clinical features and risk factors

Sánchez-López

Araujo

Cardona

et al. 2020

Allergy

View full text Add to dashboard Cite

Background In up to 70%–80% of patients with a suspected non‐steroidal anti‐inflammatory drug hypersensitivity (NSAIDH), challenge tests with the culprit drug yield negative results. On the other hand, there could be a NSAIDH overdiagnosis when anaphylaxis is the clinical manifestation. We hypothesize that some negative NSAID challenge tests and an overdiagnosis of NSAIDH occur in patients with food‐dependent NSAID‐induced hypersensitivity (FDNIH). Methods We studied 328 patients with a suspected acute NSAIDH. FDNIH was diagnosed in patients meeting all the following: (1) tolerance to the food ingested more temporally closed before the reaction, later the episode, (2) respiratory or cutaneous symptoms or anaphylaxis related to NSAID, (3) positive skin prick test to foods and/or specific IgE to food allergens (Pru p 3, Tri a 19, Pen a 1) involved in the reaction, and (4) negative oral provocation test to the culprit NSAID. Results 199 patients (60%) were diagnosed with NSAIDH and 52 (16%) with FDNIH. Pru p 3 was involved in 44 cases (84.6%) and Tri a 19 in 6 cases (11%). FDNIH subjects were younger (p < .001), with a higher prevalence of rhinitis (p < .001) and previous food allergy (p < .001), together with a higher proportion of subjects sensitized to pollens (p < .001) and foods (p < .001). Using just four variables (Pru p 3 sensitization, Tri a 19 sensitization, anaphylaxis, and any NSAID different from pyrazolones), 95.3% of cases were correctly classified, with a sensitivity of 92% and specificity of 96%. Conclusion Evaluation of FDNIH should be included in the diagnostic workup of NSAIDH.

show abstract

Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway

Shi,

Zhang,

Pei

et al. 2024

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Adenosma buchneroides Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of China for treating inflammation-related skin swelling, acne, and diarrhoea, among other conditions. In this study, we aimed to evaluate the anti-inflammatory activities and explore the molecular mechanisms of fleagrass on treating skin swelling and acne. The results demonstrated that fleagrass inhibited the enzymatic activities of 5-LOX and COX-2 in vitro, and decreased the release of NO, IL-6, TNF-α, and IL-10 in the LPS-induced RAW264.7 macrophages. The levels of proteins associated with the nuclear factor-kappa B (NF-κB) pathway were examined by western blotting and immunofluorescence, demonstrating that fleagrass downregulated the expression of TLR4, MyD88, NF-κB/p65, and iNOS and blocked the nuclear translocation of NF-κB/p65. Furthermore, fleagrass exhibited acute anti-inflammatory activity in paw oedema models. The results confirm that fleagrass exhibits remarkable anti-inflammatory activity and can be used in alleviating inflammation, suggesting that fleagrass has the potential to be a novel anti-inflammatory agent. Graphical Abstract

show abstract

Adverse reactions to nonsteroidal anti-inflammatory drugs and hypersensitivity to lipid transfer proteins

Cited by 7 publications

References 9 publications

The clinical relevance of lipid transfer protein

The clinical relevance of lipid transfer protein

Food‐dependent NSAID‐induced hypersensitivity (FDNIH) reactions: Unraveling the clinical features and risk factors

Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway

Contact Info

Product

Resources

About