Adverse reactions to quinidine in hospitalized patients: Findings based on data from the boston collaborative drug surveillance program

Quinidine‐induced agranulocytosis

“…Adverse reactions to this drug are well recognized and the most frequent ones are: gastrointestinal (GI) intolerance, cardiac arrhythmias, fever with and without hepatic dysfunction, dermatologic reactions, cinchonism, and hemolytic anemia [2]. Among 652 patients studied by Cohen et a1 [2], quinidine-induced adverse hematologic reaction was only 1 % .…”

Cost-effectiveness of Therapies for Patients With Nonvalvular Atrial Fibrillation

“…As shown in Figure 1, up to 25% of patients receiving quinidine after cardioversion discontinue treatment because of adverse effects. [47][48][49] The meta-analysis by Coplen et al 14 has raised concerns about the safety of quinidine in atrial fibrillation. The overall mortality rate was 2.9% per year in patients receiving quinidine compared with 0.8% per year in the control groups, a 3-fold increase.…”

Optimal antiarrhythmic drug therapy for electrical storm

“…Other known common side effects include the drugs' anticholinergic effects, resulting in urinary hesitancy. More worrisome adverse effects include thrombocytopenia, lupus-like syndrome, and cinchonism[96].…”