Adverse Side Effects Associated with the Use of Low-Dose Metronomic Chemotherapy

Santos, Keemo Delos; Lien, Kelly; Georgsdottir, Soley; Sivanathan, Lavarnan; Emmenegger, Urban

doi:10.1007/978-3-662-43604-2_18

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2024

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“…However, prolonged use of OMCT can lead to immunosuppression and result in unusual infections. 1 Here we describe a rare case of bilateral cytomegalovirus (CMV) retinitis in a patient with relapsed Non-Hodgkin Lymphoma on OMCT.…”

Section: Introductionmentioning

confidence: 98%

Bilateral CMV Retinitis in a Patient with Relapsed Non-Hodgkin Lymphoma on Oral Metronomic Chemotherapy: Case Report and Review of Literature

Saj

Deb

Kaliaperumal

et al. 2022

Indian J Med Paediatr Oncol

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Cytomegalovirus (CMV) retinitis is one of the common complications in profoundly immunosuppressed patients such as those with acquired immune deficiency syndrome. It has been rarely reported in patients with lymphoma on aggressive chemotherapy. We encountered a patient with bilateral CMV retinitis who developed this vision-threatening complication while on low-dose palliative metronomic chemotherapy with oral drugs (cyclophosphamide, procarbazine, etoposide, and prednisolone). Though the infection resolved with treatment, there was residual vision loss. This case is presented to sensitize clinicians to the possibility of unusual infections in patients on long-term oral chemotherapies.

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Section: Introductionmentioning

confidence: 98%