Aeca and Anca in Patients With Premature Atherosclerosis

Haelst, P.L. van; Kobold, Anneke C. Muller; Doormaal, Jasper J. van; Tervaert, Jwc

doi:10.1080/08830180210412

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…Recent findings support the idea that oxLDL and b2GPI form complexes and during atherosclerotic events antibodies are formed against these complexes [1]. Other autoantibodies, such as antiendothelial cell antibodies (AECA), anti-cholesterol antibodies (ACHA) have been described to be players in the development of endothelial damage and atherosclerosis [1,[15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 75%

Th1/Th2 Imbalance, Measured by Circulating and Intracytoplasmic Inflammatory Cytokines – Immunological Alterations in Acute Coronary Syndrome and Stable Coronary Artery Disease

et al. 2006

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To describe how peripheral immune‐parameters reflect the inflammatory alterations of the atherosclerotic plaques in coronary atherosclerosis. We measured general inflammatory markers C‐reactive protein (CRP) and granulocyte activity, lymphocyte subpopulations and their state of activation, evaluated circulating Th1/Th2‐type cytokines, and specific intracytoplasmic cytokines. We investigated the association of immune‐parameters with disease outcome and mortality. Thirty‐three patients with acute coronary syndrome (ACS), 62 with stable coronary artery disease (CAD) and 58 healthy controls were studied. Peripheral blood lymphocyte subgroups were quantified by flow cytometry, soluble cytokines and autoantibodies were assessed using enzyme‐linked immunosorbent assay (ELISA), while intracellular cytokine levels were measured by flow cytometry after intracellular staining. We found elevated levels of CRP and granulocyte activity in ACS versus CAD (P < 0.001, P = 0.017, respectively). Natural killer (NK) cell percentages were elevated, while percentage of T cells to the total lymphocyte count was slightly decreased in ACS compared to controls (P < 0.0001, P = 0.012, respectively). Both forms of coronary atherosclerosis showed significantly higher percentages of activated T cells than controls when stained for the activation markers HLA‐DR3 and CD69+ (ACS: P < 0.0001, P = 0.002, CAD: P < 0.0001, P = 0.018, respectively). IL‐1, IL‐4 and IL‐10 proved significantly higher in ACS versus controls (P = 0.036, P = 0.01, P < 0.0001 respectively). Th1 to Th2 ratio shifted towards a Th1 dominance in both diseases. Both general proinflammatory markers and activated T cells signify CAD. The orchestrated proinflammatory cascade eventually leads to the development of the disease.

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Section: Introductionmentioning

confidence: 75%

Th1/Th2 Imbalance, Measured by Circulating and Intracytoplasmic Inflammatory Cytokines – Immunological Alterations in Acute Coronary Syndrome and Stable Coronary Artery Disease

et al. 2006

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“…Increased numbers of CEC detached from vessel wall due to a variety of factors related to endothelial damage, such as oxidative stress, infectious agents, cytokines, proteases [36], antiendothelial cell antibodies [37], and disturbed flow-induced p53 and ERK5 SUMOylation [38]. It is not known clearly whether CEC are proinflammatory [39].…”

Section: Circulating Endothelial Cellsmentioning

confidence: 99%

Circulating Endothelial Cells and Chronic Kidney Disease

Zhang

Yin

Lin

2014

BioMed Research International

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Endothelial dysfunction may play a crucial role in initiation of the pathogenesis of vascular disease and atherosclerosis. The identification and quantification of circulating endothelial cells (CEC) have been developed as a novel marker of endothelial function. We describe, in great detail, mechanisms of endothelial dysfunction and CEC detachment. We also review the relationship between numbers of CEC and disease severity and response to treatment. In addition, we describe the possible clinical use of CEC in chronic kidney disease (CKD) and kidney transplantation. In summary, CEC have been developed as a novel approach to assess the endothelial damage. Measurement of the CEC level would provide an important diagnostic and prognostic value on the endothelium status and the long-term outcome of vascular dysfunction.

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“…Animal studies may be required in established models of hypertension to look more closely at the links between structure, function, and local as well as circulating AECA composition. The limitation of the relatively small numbers is known, but this sample size is broadly similar to the number of patients studied in previous works [27].…”

Section: Discussionmentioning

confidence: 88%