Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats

Abstract

Myocardial infarction is a major public health concern and the leading cause of death throughout the world. The present study investigates the ability of Aegle marmelos fruit extract to prevent pathological changes and oxidative stress after isoproterenol induced myocardial infarction in rats. In vitro studies showed that Aegle marmelos fruit extract possesses antioxidant activity. Administration of isoproterenol (85 mg/kg body weight) to rats resulted in significantly elevated plasma transaminases, lactate dehydrogenase and creatine kinase, however, cardiac tissue analyses showed decreased activity of the above enzymes compared to experimental control rats. Further, isoproterenol administration significantly increased plasma and cardiac tissue thiobarbituric acid reactive substances and lowered the activities of cardiac tissue superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and glutathione-S-transferase when compared to control groups. Pretreatment with Aegle marmelos fruit extract at a dose of 150 mg/kg body weight for a period of 45 days significantly prevented the observed alterations. Our data suggest that Aegle marmelos fruit extract exerts its protective effect by decreasing thiobarbituric acid reactive substances and elevating antioxidants status in isoproterenol treated rats. Both biochemical and histopathological results in the isoproterenol-induced myocardial infarction model emphasize the beneficial action of Aegle marmelos fruit extract as a cardioprotective agent.

Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats

“…The search for an effective medicine to treat cardiovascular disorders without any side effects has lead to the use of traditional plant based medicine. The indigenous plants such as Aegle marmelos (Krushna et al, 2011), Inula racemosa (Ojha et al, 2011), Punica granatum (Mohan et al, 2010), Myristica fragrans (Kareem et al, 2009), Moringa oleifera (Nandave et al, 2009) and Embelia ribes Burm (Bhandari et al, 2008) have been proved for their cardioprotective activity against ISO-induced MI in rats.…”

Investigation of antidiabetic action ofAntidesma buniusextract in type 1 diabetes

“…Herbal drugs are widely used, even when their biologically active compounds are unknown, due to their effectiveness, minimal side effects in clinical experience and relatively lower costs (Krushna et al, 2012).…”

Evaluation of biochemical effects of Casuarina equisetifolia extract on gentamicin-induced nephrotoxicity and oxidative stress in rats. Phytochemical analysis

“…Reports revealed that compounds in their natural formulations are more active than isolated form. (9) …”