Aeroallergens in Atopic Dermatitis and Chronic Urticaria

Chong, Albert C.; Chwa, Won Jong; Ong, Peck Y.

doi:10.1007/s11882-022-01033-2

Cited by 20 publications

(16 citation statements)

References 99 publications

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“…Aeroallergens are recently established triggers of AD and produce cutaneous reactions likely through direct skin contact 209 , 210 [ Figure 1 ]. Triggers include indoor aeroallergens (ie, HDM, pet dander, fur, cockroach, and mold) and outdoor aeroallergens (ie, tree, grass, and weed pollens) [ Table 3 ].…”

Section: Environmental Contributionsmentioning

confidence: 99%

“… 211 Upon penetrating the defective skin barrier, allergens may be presented in an IgE-facilitated or IgE-independent manner to T cells with subsequent release of Th2 cytokines IL4, IL13, and IL31 and downstream effects of B cell maturation to plasma cells and pruritus. 210 Alternatively, allergens may directly trigger neurons to release substance P and degranulate skin mast cells via the MRGPRX2 receptor. 212 , 213 Recently, propyl-paraben exposure has been linked with aeroallergen sensitization and AD severity.…”

Section: Environmental Contributionsmentioning

confidence: 99%

“… 217 Currently, management centers on avoidance and maintenance of the skin barrier. 210 Avoidance includes removing pets or keeping them in another room, implementing dust mite-proof pillow or mattress encasings, and wearing occlusive clothing outdoors. Skin moisturization and TCS for flares are recommended to restore and maintain the skin barrier.…”

Section: Environmental Contributionsmentioning

confidence: 99%

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Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis

Chong¹,

Visitsunthorn²,

Ong³

2022

JAA

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Atopic dermatitis (AD) is one of the most common skin conditions in humans. AD affects up to 20% of children worldwide and results in morbidity for both patients and their caregivers. The basis of AD is an interplay between genetics and the environment characterized by immune dysregulation. A myriad of mutations that compromise the skin barrier and/or immune function have been linked to AD. Of these, filaggrin gene ( FLG ) mutations are the most evidenced. Many other mutations have been implicated in isolated studies that are often unreplicated, creating an archive of genes with potential but unconfirmed relevance to AD. Harnessing big data, polygenic risk scores (PRSs) and genome-wide association studies (GWAS) may provide a more practical strategy for identifying the genetic signatures of AD. Epigenetics may also play a role. Staphylococcus aureus is the most evidenced microbial contributor to AD. Cutaneous dysbiosis may result in over-colonization by pathogenic strains and aberrant skin immunity and inflammation. Aeroallergens, air pollution, and climate are other key environmental contributors to AD. The right climate and/or commensals may improve AD for some patients.

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Section: Environmental Contributionsmentioning

confidence: 99%

Section: Environmental Contributionsmentioning

confidence: 99%

Section: Environmental Contributionsmentioning

confidence: 99%

See 1 more Smart Citation

Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis

Chong¹,

Visitsunthorn²,

Ong³

2022

JAA

Self Cite

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“…The abundant vegetation also attracts a substantial insect population, commonly leading contact urticaria. (32) Considering Nepal’s traditional culture, the use of spices may also be a potential risk factor, though there is no experimental evidence has yet to confirm this. Along with a wealth of disease-causative factors and low per capita healthcare expenditure, Nepal ranks highest in ASIR, ASPR, and DALYs.…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national levels and trends in burden of urticaria: a systematic analysis for the global burden of disease 2019 study

Pu,

He,

Wang

et al. 2023

Preprint

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Background: Urticaria causes a significant burden on individuals and society due to its pervasiveness. The aim of this study was to evaluate the burden of urticaria in different regions and nations by analyzing data from the Global Burden of Disease Study 2019 (GBD 2019) to provide a reference for healthcare policymakers. Methods: Using the GBD 2019 database, this study analyzed incidence, prevalence, disability-adjusted life year (DALY), and corresponding ASRs and EAPC globally and in 204 countries and regions, and stratified the data by age, sex, and sociodemographic index (SDI). Results: In 2019, the global incidence cases of urticaria increased to 114708912.2, the prevalence cases increased to 65139886.6, and the global DALY burden increased to 3898838.6. The distribution of the burden was markedly geographically heterogeneous. Burden indicators were generally higher in females than in males. There was a slight positive correlation between urticaria burden and regional SDI. Interpretation: The burden of urticaria has been increasing globally from 1990 to 2019. This study identified multiple determinants that influence the burden of urticaria, such as geographic location and SDI. Despite the limitations of the GBD 2019 data, these discoveries provide a valuable resource for the development of future public health strategies aimed at reducing the burden of urticaria.

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“…Studies have shown that AR and CSU have common triggers, of which pollen is the important incentive ( 14 ). In detail, data from clinical trials confirmed that there was a significant correlation between allergic reaction with pollen counts ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

DNA methylation regulatory patterns and underlying pathways behind the co-pathogenesis of allergic rhinitis and chronic spontaneous urticaria

et al. 2023

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BackgroundAllergic rhinitis (AR) and chronic spontaneous urticaria (CSU) are often concurrent in patients. Changes in DNA methylation affect T cell biological processes, which may explain the occurrence and progression of comorbidity. However, downstream regulatory pathways of DNA methylation in two diseases and the underlying mechanisms have not been fully elucidated.MethodsThe GSE50101, GSE72541, GSE50222 and OEP002482 were mined for the identification of differentially expressed genes (DEGs) or co-expressed genes and differentially methylated genes (DMGs) in AR and CSU patients. We applied GO analysis and consensus clustering to study the potential functions and signal pathways of selected genes in two diseases. GSVA and logistic regression analysis were used to find the regulatory pathway between DNA methylation and activation patterns of CD4+ T cells. Besides, we used the Illumina 850k chip to detect DNA methylation expression profiles and recognize the differentially methylated CpG positions (DMPs) on corresponding genes. Finally, we annotated the biological process of these genes using GO and KEGG pathway analysis.ResultThe AR-related DEGs were found closely related to the differentiation and activation of CD4+ T cells. The DEGs or co-expressed genes of CD4+ T cells in AR and CSU patients were also clustered using GO and KEGG analysis and we got 57 co-regulatory pathways. Furthermore, logistic regression analysis showed that the regulation of cellular component size was closely related to the activation of CD4+ T cells regulated by DNA methylation. We got self-tested data using the Illumina 850k chip and identified 98 CpGs that were differentially methylated in patients. Finally, we mapped the DMPs to 15 genes and found that they were mainly enriched in the same CD4+T cell regulating pathway.ConclusionOur study indicated that DNA methylation affected by pollen participated in the activation patterns of CD4 + T cells, providing a novel direction for the symptomatic treatment of the co-occurrence of AR and CSU.

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Aeroallergens in Atopic Dermatitis and Chronic Urticaria

Cited by 20 publications

References 99 publications

Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis

Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis

Global, regional, and national levels and trends in burden of urticaria: a systematic analysis for the global burden of disease 2019 study

DNA methylation regulatory patterns and underlying pathways behind the co-pathogenesis of allergic rhinitis and chronic spontaneous urticaria

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