Aerobic capacity in persons with Parkinson’s disease: a systematic review

Thrue, Cecilie; Hvid, Lars G.; Gamborg, Mads; Dawes, Helen; Dalgas, Ulrik; Langeskov‐Christensen, Martin

doi:10.1080/09638288.2022.2094480

Cited by 6 publications

(3 citation statements)

References 67 publications

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“…Submaximal tests, as used in this study, are known to overestimate true VO2max [38] which suggests cardiovascular fitness in PD may be more reduced than findings presented. Mean estimated VO2max reported in Table 2 is notably higher than findings published in a systematic review of aerobic capacity in PD (22.2 mL O 2 �kg −1 �min −1 and 21.9 mL O 2 �kg −1 �min −1 in ON and OFF phases respectively [94]). In addition, contrary to findings presented in this study, the systematic review reported no differences between individuals with PD and healthy controls in their cardiovascular fitness.…”

Section: Plos Onecontrasting

confidence: 56%

Responsiveness of respiratory function in Parkinson’s Disease to an integrative exercise programme: A prospective cohort study

McMahon,

McGrath,

Blake

et al. 2024

PLoS ONE

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Introduction Respiratory disorders are the most common cause of death in Parkinson’s Disease (PD). Conflicting data exist on the aetiology of respiratory dysfunction in PD and few studies examine the effects of exercise-based interventions on respiratory measures. This study was conducted to better understand respiratory dysfunction in PD and to identify measures of dysfunction responsive to an integrative exercise programme. Objectives The objectives were to compare baseline respiratory measures with matched, published population norms and to examine immediate and longer-term effects of a 12-week integrated exercise programme on these measures. Design Twenty-three people with mild PD (median Hoehn & Yahr = 2) self-selected to participate in this exploratory prospective cohort study. Evaluation of participants occurred at three time points: at baseline; following the 12-week exercise programme and at 4-month follow-up. Outcome measures Outcome measures included: Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), FEV1/FVC ratio, Peak Expiratory Flow (PEF), Inspiratory Muscle Strength (MIP), Expiratory Muscle Strength (MEP), Peak Cough Flow (PCF), and Cardiovascular Fitness measures of estimated VO2 max and 6-Minute Walk Test (6MWT). Results Compared to published norms, participants had impaired cough, reduced respiratory muscle strength, FEV, FVC, PEF and cardiovascular fitness. Post exercise intervention, statistically significant improvements were noted in MEP, cardiovascular fitness, and PEF. However only gains in PEF were maintained at 4-month follow-up. Conclusions Significant respiratory dysfunction exists, even in the early stages of PD. Metrics of respiratory muscle strength, peak expiratory flow and cardiovascular fitness appear responsive to an integrative exercise programme.

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Section: Plos Onecontrasting

confidence: 56%

Responsiveness of respiratory function in Parkinson’s Disease to an integrative exercise programme: A prospective cohort study

McMahon,

McGrath,

Blake

et al. 2024

PLoS ONE

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“…Our study showed that the training-induced gain on fatigue was significantly higher in the LFG than in both the HFG and CG, and the HFG perceived significantly less fatigue than the CG. The concept that exercise counteracts the perception of fatigue is supported by the worsening of the CG over time ( Thrue et al, 2022 ). LFG training, such as aerobic-based training, improves central fatigue in individuals with PD because of increased exercise tolerance and strength as well as coordination, that are promising means to increase the basal ganglia volume ( Juvet et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Whole body-electromyostimulation effects on serum biomarkers, physical performances and fatigue in Parkinson’s patients: A randomized controlled trial

Cagno

Buonsenso²,

Centorbi³

et al. 2023

Front. Aging Neurosci.

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BackgroundWhole-body electromyostimulation (WB-EMS) was never previously applied to Parkinson’s disease (PD) patients. This randomized controlled study aimed to find the most effective and safe WB-EMS training protocol for this population.MethodsTwenty-four subjects (age: 72.13 ± 6.20 years), were randomly assigned to three groups: a high-frequency WB-EMS strength training group (HFG) (rectangular stimulation at 85 Hz, 350 μs, 4 s stimulation/4 s rest), a low-frequency WB-EMS aerobic training group (LFG) (rectangular stimulation 7 Hz, 350 μs, with a continuous pulse duration), and an inactive control group (CG). Participants of the two experimental groups underwent 24 controlled WB-EMS training sessions, with a duration of 20 min each, during 12-week intervention. Serum growth factors (BDNF, FGF-21, NGF and proNGF), α-synuclein, physical performance and Parkinson’s Disease Fatigue Scale (PFS-16) responses were analyzed to evaluate the pre-post variation and differences among groups.ResultsSignificant interactions of Time*Groups were detected for BDNF (Time*Groups p = 0.024; Time*CG, b = −628, IC95% = −1,082/−174, p = 0.008), FGF-21 (Time*Groups p = 0.009; Time*LFG b = 1,346, IC95% = 423/2268, p = 0.005), and α-synuclein (Time*Groups p = 0.019; Time*LFG b = −1,572, IC95% = −2,952/−192, p = 0.026). Post hoc analyses and comparisons of ΔS (post–pre), performed independently for each group, showed that LFG increased serum BDNF levels (+ 203 pg/ml) and decreased α-synuclein levels (−1,703 pg/ml), while HFG showed the opposite effects (BDNF: −500 pg/ml; α-synuclein: + 1,413 pg/ml). CG showed a significant BDNF reduction over time. Both LFG and HFG showed significant improvements in several physical performance outcomes and the LFG showed better results than HFG. Concerning PFS-16, significant differences over time (b = −0.4, IC95% = −0.8/−0.0, p = 0.046) and among groups (among all groups p < 0.001) were found, and the LFG exhibited better results than the HFG (b = −1.0, IC95% = −1.3/−0.7, p < 0.001), and CG (b = −1.7, IC95% = −2.0/−1.4, p < 0.001) with this last one that worsened over time.ConclusionLFG training was the best choice for improving or maintaining physical performance, fatigue perception and variation in serum biomarkers.Clinical trial registrationhttps://www.clinicaltrials.gov/ct2/show/NCT04878679, identifier NCT04878679.

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“…Many studies have demonstrated the influence of motor training on cognition in people with neurological diseases [ 23 , 24 , 25 ]. In pwPD, cognitive functioning has been investigated after various kinds of aerobic, walking or dance training [ 26 , 27 ]. The data indicate that the involvement of the lower limbs has an influence specifically on executive function, verbal memory, language and attention [ 26 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

et al. 2022

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Parkinson’s disease is characterized by motor and cognitive deficits that usually have an impact on quality of life and independence. To reduce impairment, various rehabilitation programs have been proposed, but their effects on both cognitive and motor aspects have not been systematically investigated. Furthermore, most intervention is focused on lower limb treatment rather than upper limbs. In the present study, we investigated the effect of 3-week upper limb vibratory stimulation training on cognitive functioning in 20 individuals with Parkinson’s disease. We analyzed cognitive (Montreal Cognitive Assessment, Trial Making Test, Digit Symbol, Digit Span Forward and Backward and Alertness) and motor performance (Unified Parkinson’s Disease Rating Scale—part III; Disability of the Arm, Shoulder and Hand Questionnaire) before treatment, at the end of treatment and one month post treatment. After rehabilitation, a statistically significant improvement was observed in terms of global cognitive status, attention, global motor functioning and disability. The results suggest an impact of upper limb motor rehabilitation on cognition in Parkinson’s disease. Future studies on neuromotor interventions should investigate their effects on cognitive functioning to improve understanding of cognitive motor interaction in Parkinson’s disease.

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Aerobic capacity in persons with Parkinson’s disease: a systematic review

Cited by 6 publications

References 67 publications

Responsiveness of respiratory function in Parkinson’s Disease to an integrative exercise programme: A prospective cohort study

Responsiveness of respiratory function in Parkinson’s Disease to an integrative exercise programme: A prospective cohort study

Whole body-electromyostimulation effects on serum biomarkers, physical performances and fatigue in Parkinson’s patients: A randomized controlled trial

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

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