Aerobic exercise as therapy for cancer fatigue

Dimeo, Fernando; Rumberger, Brigitta; Keul, J.

doi:10.1097/00005768-199804000-00001

Cited by 197 publications

(131 citation statements)

References 8 publications

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“…Fatigue experienced by cancer patients has been described as a process in which both psychological and physiological changes during and after the administration of cancer treatments lead patients to experience a decrease in their overall functionality (9). There was a significant inverse relationship observed in the current study demonstrating an increase in TCI paired with a reduction in fatigue levels in patients assigned to the exercise group.…”

Section: Discussionsupporting

confidence: 44%

“…Exercise training programs have been shown to improve the overall quality of life, level of fitness, improved levels of self-esteem, and confidence of cancer patients (9). It has also been sug-Exercise by breast cancer patients www.bjournal.com.br significant relationship between TCI and fatigue.…”

Section: Resultsmentioning

confidence: 99%

“…Energy loss usually observed during treatment has been shown to improve with an aerobic training program (9). Results from studies that explored aerobic and resistance training as the exercise modes showed positive effects on decreasing fatigue levels, improvement in quality of life, and muscle strength (7,8,10,11).…”

Section: Introductionmentioning

confidence: 99%

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Effect of exercise on the caloric intake of breast cancer patients undergoing treatment

Battaglini

Mihalik

Bottaro

et al. 2008

Braz J Med Biol Res

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The purpose of this study was to examine the effects of an exercise intervention on the total caloric intake (TCI) of breast cancer patients undergoing treatment. A secondary purpose was to determine whether or not a relationship existed between changes in TCI, body fat composition (%BF), and fatigue during the study, which lasted 6 months. Twenty females recently diagnosed with breast cancer, scheduled to undergo chemotherapy or radiation, were assigned randomly to an experimental (N = 10) or control group (N = 10). Outcome measures included TCI (3-day food diary), %BF (skinfolds), and fatigue (revised Piper Fatigue Scale). Each exercise session was conducted as follows: initial cardiovascular activity (6-12 min), followed by stretching (5-10 min), resistance training (15-30 min), and a cool-down (approximately 8 min). Significant changes in TCI were observed among groups (F 1,18 = 8.582; P = 0.009), at treatments 2 and 3, and at the end of the study [experimental (1973 ± 419), control (1488 ± 418); experimental (1946 ± 437), control (1436 ± 429); experimental (2315 ± 455), control (1474 ± 294), respectively]. A significant negative correlation was found (Spearman rho (18) = -0.759; P < 0.001) between TCI and %BF and between TCI and fatigue levels (Spearman rho (18) = -0.541; P = 0.014) at the end of the study. In conclusion, the results of this study suggest that an exercise intervention administered to breast cancer patients undergoing medical treatment may assist in the mitigation of some treatment side effects, including decreased TCI, increased fatigue, and negative changes in body composition.

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Section: Discussionsupporting

confidence: 44%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of exercise on the caloric intake of breast cancer patients undergoing treatment

Battaglini

Mihalik

Bottaro

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…CRF typically leads to decreased activity levels, contributes to a reduction in one's overall QOL and is often accompanied by anxiety and depression. CRF is known to be a complex process that is influenced by muscle catabolism and protein loss, weight loss, a decline in neuromuscular efficiency, de-conditioning, cancer treatment factors, decreased sleep, insomnia and anemia (17,18).…”

Section: Introductionmentioning

confidence: 99%

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients

Yeo

Burrell

Sauter

et al. 2012

Journal of the American College of Surgeons

110

148

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A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients. Recommended Citation Yeo, Theresa; Burrell, Sherry A; Sauter, Patricia K; Kennedy, Eugene P; Lavu, Harish; Leiby, Benjamin E; and Yeo, Charles, "A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients." (2012 Methods:One hundred and two patients with resected PPC consented to participate in this study and were randomized to either an Intervention Group (IG) or a Usual Care Group (UCG).Subjects completed visual analog scales, the FACIT-Fatigue Scale (FFS) and the Short Form36v2® after surgery and again 3 to 6 months after hospital discharge. Results:Patients in the IG and UCG were comparable with regard to demographics, comorbidities, cancer type and staging, type of resection, pre-op fatigue and pain levels, adjuvant therapy and baseline walking distance. Patients in the IG had significantly improved scores on the FFS at study completion, improved fatigue and pain scores, as well as overall physical functioning and mental health composite scores. At study completion, participants in the IG were walking twice as far and were significantly more likely to have continued walking or another form of exercise as compared to the UCG. Using hierarchical cluster analysis three mutually exclusive symptom groupings were identified in the cohort. Kaplan-Meier survival analysis did not indicate an overall survival benefit for the IG. Conclusion:This is the first prospective, randomized and controlled trial to report that participation in a home walking program confers a significant benefit in resected PPC patients

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“…21 There are few case reports in the literature regarding respiratory muscle strength [22][23][24] and the serial level of muscle degradation enzymes. 25,26 In the literature there are reports that suggest that exercise programs improve physical performance in patients undergoing BMT, 27 but these studies have evaluated other parameters and did not directly address muscle strength. The purpose of this study was to analyze how an exercise program may affect the muscle strength of patients undergoing BMT.…”

mentioning

confidence: 99%

Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation

Mello

Tanaka

Dulley

2003

Bone Marrow Transplant

162

143

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Summary:Allogeneic bone marrow transplantation (BMT) has been successfully used for the treatment of several hematological malignancies; however, it is associated with transplant-related toxicities such as functional impairment and muscle weakness. In order to analyze how an exercise program may influence muscle strength in patients undergoing BMT, we carried out a prospective study assessing patients from the pre-BMT phase to 16 weeks post-BMT. In all, 18 patients underwent three trials: (1) pre-BMT, (2) after marrow engraftment, and (3) 6 weeks after trial 2. After trial 2, the patients were randomized in a control group (CG) or treatment group (TG), which received a 6-week exercise program with active exercise, muscle stretching and treadmill walking. The results obtained in trial 1 showed similar values for CG and TG, as both groups had muscle strength lower than normal patterns based on data concerning age, sex and weight. In trial 2, CG and TG showed similarly decreased values. In trial 3, TG showed values higher than CG for all muscle groups tested. These results suggest that the exercise program was efficient in promoting an increase of muscle strength after allogeneic BMT.

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Aerobic exercise as therapy for cancer fatigue

Abstract: We conclude that an aerobic exercise program of precisely defined intensity, duration, and frequency can be prescribed as therapy for primary fatigue in cancer patients.

Cited by 197 publications

References 8 publications

Effect of exercise on the caloric intake of breast cancer patients undergoing treatment

Effect of exercise on the caloric intake of breast cancer patients undergoing treatment

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients

Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation

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