Aerobic Exercise Decreases Chronic Allergic Lung Inflammation and Airway Remodeling in Mice

Vieira, Rodolfo Paula; Claudino, Renata C.; Duarte, Anna Cecília S; Santos, Ângela Batista Gomes dos; Perini, Adenir; Neto, Hugo Caire Castro-Faria; Mauad, Thaís; Martins, Mílton A.; Dolhnikoff, Marisa; Carvalho, Celso Ricardo Fernandes

doi:10.1164/rccm.200610-1567oc

Cited by 164 publications

(244 citation statements)

References 47 publications

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“…In spite of the well-described effects of aerobic training of moderate intensity in eliciting anti-inflammatory effects in asthma (21,24), no information is available regarding the effects of training on peripheral skeletal muscle in this disease. Previous studies have demonstrated that this type of exercise may be used to prevent muscle atrophy under disuse conditions (32,33).…”

Section: Discussionmentioning

confidence: 99%

“…Next, a maximal exercise capacity test was performed with a 5-min warm-up (0.2 km/h) followed by an increase in treadmill speed (every 2.5 min) until animal exhaustion, i.e., after 10 mechanical stimuli (21). Maximal aerobic capacity (100%) was established as the maximal speed reached by each animal.…”

Section: Aerobic Exercise Treadmill Test and Aerobic Conditioningmentioning

confidence: 99%

“…Maximal aerobic capacity (100%) was established as the maximal speed reached by each animal. Mice were exercise trained at low or moderate intensity (50 or 75% of maximal speed reached in the test, respectively) for 60 min a day, 5 days a week for 12 weeks (8 weeks before sensitization + 4 weeks after OA or saline exposure) (21). The improvement in exercise capacity was confirmed by repeating the maximal exercise test after 12 weeks of physical training (72 h before sacrifice).…”

Section: Aerobic Exercise Treadmill Test and Aerobic Conditioningmentioning

confidence: 99%

“…We recently demonstrated that animals previously submitted to chronic airway allergic inflammation followed by aerobic exercise training presented a decrease in airway inflammation and remodeling in a murine model of asthma (21). Nevertheless, relatively little is known about the effects of aerobic training before the development of the allergic response in peripheral skeletal muscles of asthmatic animals.…”

Section: Introductionmentioning

confidence: 99%

“…A corollary was that aerobic physical training applied before the induction of chronic allergic lung inflammation could reduce these effects. Since different intensities of aerobic training may induce different adaptations in the asthmatic inflammatory response (21,24,25), we analyzed the effect of two aerobic treadmill training intensities in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

Durigan

Peviani

Russo

et al. 2009

Braz J Med Biol Res

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We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trained (C); 2) ovalbumin sensitized (OA, 20 μg per mouse); 3) non-sensitized and trained at 50% maximum speed -low intensity (PT50%); 4) non-sensitized and trained at 75% maximum speed -moderate intensity (PT75%); 5) OA-sensitized and trained at 50% (OA+PT50%), 6) OA-sensitized and trained at 75% (OA+PT75%). There was no difference in muscle fiber cross-sectional area among groups and no difference in atrogin-1 and MuRF1 expression between C and OA groups. All exercised groups showed significantly decreased expression of atrogin-1 compared to C (1.01 ± 0.2-fold): PT50% = 0.71 ± 0.12-fold; OA+PT50% = 0.74 ± 0.03-fold; PT75% = 0.71 ± 0.09-fold; OA+PT75% = 0.74 ± 0.09-fold. Similarly significant results were obtained regarding MuRF1 gene expression compared to C (1.01 ± 0.23-fold): PT50% = 0.53 ± 0.20-fold; OA+PT50% = 0.55 ± 0.11-fold; PT75% = 0.35 ± 0.15-fold; OA+PT75% = 0.37 ± 0.08-fold. A short period of OA did not induce skeletal muscle atrophy in the mouse tibialis anterior muscle and aerobic training at low and moderate intensity negatively regulates the atrophy pathway in skeletal muscle of healthy mice or mice with allergic lung inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Aerobic Exercise Treadmill Test and Aerobic Conditioningmentioning

confidence: 99%

Section: Aerobic Exercise Treadmill Test and Aerobic Conditioningmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

Durigan

Peviani

Russo

et al. 2009

Braz J Med Biol Res

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Chronic exercise decreases cytokine production in healthy rat skeletal muscle

Lira

Koyama

Yamashita

et al. 2009

Cell Biochemistry & Function

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Skeletal muscle is the source of pro- and anti-inflammatory cytokines, and recently, it has been recognized as an important source of interleukin-6 (IL-6). Acute physical exercise is known to induce a pro-inflammatory cytokine profile in the plasma. However, the effect of chronic physical exercise in the production of pro- and anti-inflammatory cytokines by the skeletal muscle has never been examined. We assessed IL-6, TNF-alpha, IL-1beta and IL-10 levels in the skeletal muscle of rats submitted to endurance training. Animals were randomly assigned to either a sedentary group (S, n = 7) or an endurance exercise trained group (T, n = 8). Trained rats ran on a treadmill for 5 days week(-1) for 8 weeks (60% VO(2max)). Detection of IL-6, TNF-alpha, IL-1beta and IL-10 protein expression was carried out by ELISA. We found decreased expression of IL-1beta, IL-6, TNF-alpha and IL-10 (28%, 27%, 32% and 37%, respectively, p < 0.05) in the extensor digital longus (EDL) from T, when compared with S. In the soleus, IL-1beta, TNF-alpha and IL-10 protein levels were similarly decreased (34%, 42% and 50%, respectively, p < 0.05) in T in relation to S, while IL-6 expression was not affected by the training protocol. In conclusion, exercise training induced decreased cytokine protein expression in the skeletal muscle. These data show that in healthy rats, 8-week moderate-intensity aerobic training down regulates skeletal muscle production of cytokines involved in the onset, maintenance and regulation of inflammation, and that the response is heterogeneous according to fibre composition.

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The chemokines secretion and the oxidative stress are targets of low‐level laser therapy in allergic lung inflammation

Carvalho

Brito

Oliveira

et al. 2016

Journal of Biophotonics

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Recent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured. Laser-treated allergic mice presented reduction of both the ICAM-1 and eosinophil in the lungs. RANTES, CCL8, CCL3 and eotaxins were reduced in BALF of laser-treated allergic mice. In allergic mice lung LLLT decreased the CCR1 and CCR3 and restored the oxidative stress balance as well. Laser decreased the lipidic peroxidation in allergic mice lung as much as increased SOD, GPx and GR. It shows that LLLT on allergic lung inflammation involves leukocyte-attractant chemokines and endogenous antioxidant. Based on results, LLLT may ultimately become a non- invasive option in allergic lung disease treatment. The top figure illustrates the laser decreasing the eosinophils migration into BALF and the bottom figure shows the laser upregulating the expression of heme-oxygenase (anti-oxidant enzyme) in lung tissue anti-oxidant.

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Aerobic Exercise Decreases Chronic Allergic Lung Inflammation and Airway Remodeling in Mice

Abstract: We concluded that low and moderate aerobic exercise decreases airway inflammation and remodeling in a murine model of asthma.

Cited by 164 publications

References 47 publications

Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

Chronic exercise decreases cytokine production in healthy rat skeletal muscle

The chemokines secretion and the oxidative stress are targets of low‐level laser therapy in allergic lung inflammation

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