Aerobic exercise effects upon cognition in Mild Cognitive Impairment: A systematic review of randomized controlled trials

Cammisuli, Davide Maria; Innocenti, Augusto; Franzoni, Ferdinando; Pruneti, Carlo

doi:10.12871/000398292017126

Cited by 38 publications

(32 citation statements)

References 19 publications

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“…These findings also suggest that particularly in the context of amyloid or TDP‐43, PA may function via other brain pathways (e.g., reduced microglial inflammation, synaptic homeostasis) to support cognition versus proteinopathy clearance, per se. Building on aerobic intervention trials that identified positive associations between improved cardiorespiratory fitness and clinical outcomes in AD 43 , 44 and amnestic MCI, 45 , 46 only a handful of prior studies examined the interacting (i.e., modifying) effect of PA on pathology and cognition. 24 , 25 , 47 , 48 Similar to our findings, the majority of these studies identified that PA is particularly beneficial at sustaining cognition in those with higher levels of AD 47 , 48 and vascular burden.…”

Section: Discussionmentioning

confidence: 99%

Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?

Memel

Buchman

Bennett

et al. 2021

Alz & Dem Diag Ass & Dis Mo

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Introduction Physical activity (PA) is associated with better cognitive and brain health. However, it remains unclear whether PA relates to accumulation of disease pathology (“resistance”) or indirectly moderates adverse effects of pathology on cognition (“cognitive resilience”). Methods Five hundred thirteen Rush Memory and Aging Project (MAP) decedents completed longitudinal actigraphy monitoring, cognitive testing, and neuropathological examination. Cross‐sectional models tested the relationship between average PA and pathology, and the moderating effect of baseline PA on the association between pathology and cognition. Longitudinal models examined whether changes in PA moderated associations between pathology and cognition. Results PA was negatively associated with Lewy body disease (LBD), but positively associated with Alzheimer's disease (AD) burdens. Baseline PA attenuated the association between cerebrovascular pathology and cognition, whereas longitudinal change in PA attenuated associations between AD, cerebral amyloid angiopathy, TAR DNA‐binding protein 43, and atherosclerosis on cognitive decline. Discussion Whereas PA relates to “cognitive resilience” against cerebrovascular disease, AD, and other neuropathologies, “resistance” effects were limited.

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Section: Discussionmentioning

confidence: 99%

Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?

Memel

Buchman

Bennett

et al. 2021

Alz & Dem Diag Ass & Dis Mo

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“…A total of 76 articles (35 meta-analyses; 41 SRs) were identified that examined effects of RCTs and prospective longitudinal studies with cognitive outcomes. These reviews included results from younger (18-50 years; N=5) (9-13) adults, older adults (N =7) (6,(14)(15)(16)(17)(18)(19), children (N= 13) (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), and adolescents (N=6) (33)(34)(35)(36)(37)(38), as well as populations with impaired cognition, such as attention deficit hyperactivity disorder (ADHD) (N=3) (39)(40)(41), mild cognitive impairment or dementia (N=13) (42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54), multiple sclerosis (N=1) (55), Parkinson's disease (N=2) (56,57), schizophrenia (N=1) (58), HIV (N=1) (59), Type 2 Diabetes (N=2) (60,…”

Section: Methodsmentioning

confidence: 99%

Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines

Erickson

Hillman

Stillman

et al. 2019

Medicine &Amp; Science in Sports &Amp; Exercise

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503

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Purpose: Physical activity (PA) is known to improve cognitive and brain function, but debate continues regarding the consistency and magnitude of its effects, populations and cognitive domains most affected, and parameters necessary to achieve the greatest improvements (e.g., dose). Methods:In this umbrella review conducted in part for the 2018 Health and Human Services Physical Activity Guidelines for Americans Advisory Committee, we examined whether PA interventions enhance cognitive and brain outcomes across the lifespan, as well as in populations experiencing cognitive dysfunction (e.g., schizophrenia). Systematic reviews, meta-analyses, and pooled analyses were used. We further examined whether engaging in greater amounts of PA is associated with a reduced risk of developing cognitive impairment and dementia in late adulthood.

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“…En general, el programa de caminata en línea recta, propuesto en este estudio se basó en intensidades de baja a moderada, lo que depende principalmente del proceso de generación de energía aeróbica en referencia al uso de oxígeno para satisfacer adecuadamente las demandas de energía durante el ejercicio 33 . Además, todas las actividades aeróbicas, como caminar, correr, nadar, hacer gimnasia acuática, bicicleta, remar, entre otras, mejoran la salud cardiovascular, la rigidez arterial, el estrés oxidativo, la inflamación sistémica y el mejoramiento de la función endotelial 34 .…”

Section: Discussionunclassified

Efectos de un programa de entrenamiento de marcha sobre las capacidad aeróbica y la función cognitiva en mujeres diabéticas de edad avanzada

Sotomayor

Gómez-Campos

Ulloa-Tapia³

et al. 2021

Rev. méd. Chile

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Effects of physical exercise on aerobic fitness and cognition in older women with type 2 diabetes mellitus Background: Among older people, physical exercise improves cognitive function, aerobic fitness, and thus functional independence. Aim: To determine the effects of a walking training program on aerobic fitness and cognitive function in older women with type 2 diabetes mellitus. Material and Methods: An experimental study was carried out in 76 women with type 2 diabetes mellitus aged between 64 and 78 years. Thirty-eight women in the exercise group (EG) participated in a controlled walking program 3 times a week for 48 sessions (60min /day) and 38 women in the control group (CG) were not trained. Weight, height, body mass index (BMI), estimated maximal oxygen uptake (VO 2 max), and cognitive function using the Minimental test were evaluated at baseline and the end of the intervention. Results: The Minimental test improved significantly in the exercise group and did not change in the control group. Estimated VO-2 max improved in women aged between 69 and 78 years. The distance walked in 6 minutes increased in all women of the experimental group. No changes in these parameters were observed in the control group. Conclusions: A structured walking program improved cognitive function, estimated aerobic capacity, and walking distance in these diabetic women.

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Aerobic exercise effects upon cognition in Mild Cognitive Impairment: A systematic review of randomized controlled trials

Cited by 38 publications

References 19 publications

Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?

Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?

Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines

Efectos de un programa de entrenamiento de marcha sobre las capacidad aeróbica y la función cognitiva en mujeres diabéticas de edad avanzada

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