Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus

Konishi, Ichiro; Hiasa, Yoichi; Terada, Yoshio; Abe, Masanori; Furukawa, Shinya; Toshimitsu, Kumiko; Matsuura, Bunzo; Onji, Morikazu

doi:10.1111/j.1872-034x.2011.00833.x

Cited by 38 publications

(30 citation statements)

References 40 publications

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“…There are several reports with similar findings; reporting the association between physical exercise and the plasma level of insulin and leptin (Konishi et al, 2011). Although investigators showed that lower concentrations of leptin and insulin stimulate appetite and energy intake and suppress energy expenditure (Benoit et al, 2004), the results of the current study demonstrated that there were significant decrease in BMI (P < 0.05), percent body fat (P < 0.01), waist circumference (P < 0.05) in obese subjects after 8 weeks exercise training and they were positively correlated with the decrease in plasma leptin level.…”

Section: Discussionsupporting

confidence: 48%

Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

Nabil¹,

Sayyad²

2015

Int. J. Nutr. Metab.

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Endocrine derangement and oxidative stress are two distinguishing features of obesity that have limited the success rate of various management strategies, especially physical activities. The objective of the current study was to examine the effect of 8 weeks of moderate-intensity regular exercise training on oxidative stress, appetite and weight loss in obese women compared with normal-weight women. Sixteen normal-weight (body mass index (BMI) < 25 kg/m 2 ) and fifteen obese women (BMI > 30 kg/m 2 ) exercised on the bicycle ergometer at moderate intensity for 30 min, 3 times per week for 8 weeks. Blood samples were collected at the first day of training and 72 h after the completion of the training program which were then used for the measurement of F2-Isoprostanes, glutathione (GSH), oxidized glutathione (GSSG), leptin, adiponectin and nesfatin-1. Eight (8) weeks of training resulted in lower BMI, insulin, GSSG (P < 0.05), leptin (P < 0.01), and F2-Isoprostanes (P < 0.001) and higher nesfatin-1 levels (P < 0.01) relative to the levels at the pre-test stage in obese women. Also ∆leptin levels after exercise were positively correlated with ∆F2-Isoprostanes and ∆BMI. Eight weeks of moderateintensity regular exercise program did not only induce weight loss and improve oxidative stress, but also modified insulin, leptin and nesfatin-1 concentrations, particularly in obese women.

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Section: Discussionsupporting

confidence: 48%

Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

Nabil¹,

Sayyad²

2015

Int. J. Nutr. Metab.

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“…No adverse events were seen in the intervention group [70]. Additionally, several studies have demonstrated that formalized exercise regimen will improve insulin sensitivity among patients with liver disease, which is particularly important among patients with sarcopenic obesity [71][72][73]. Further studies are necessary to further define the type and duration of exercises and their long-term effect on morbidity and mortality among chronic liver disease patients.…”

Section: Exercise and Preservation Of Muscle Massmentioning

confidence: 87%

Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise?

Kappus

Mendoza

Nguyen

et al. 2016

Curr Gastroenterol Rep

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Sarcopenia, a loss of muscle mass, is being increasingly recognized to have a deleterious effect on outcomes in patients with chronic liver disease. Factors related to diet and the inflammatory nature of chronic liver disease contribute to the occurrence of sarcopenia in these patients. Sarcopenia adversely influences quality of life, performance, morbidity, success of transplantation, and even mortality. Specific deficiencies in macronutrients (protein, polyunsaturated fatty acids) and micronutrients (vitamins C, D, and E, carotenoids, and selenium) have been linked to sarcopenia. Lessons learned from nutritional therapy in geriatric patient populations may provide strategies to manage sarcopenia in patients with liver disease. Combining diet modification and nutrient supplementation with an organized program of exercise may help ameliorate or even reverse the effects of sarcopenia on an already complex disease process.

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“…Eizadi et al stated that prolonged aerobic exercise improved lipid profile, reduced insulin resistance and increased insulin sensitivity in obese patients (19). Also, Konishi et al applied a program of walking exercise for 15 patients with HCV and founded that aerobic exercises decreased body fat and improved insulin resistance (20). Similarly, Jiménez and Ramírez-Vélez found that eight weeks of strength training for obese subjects improved insulin sensitivity (21).…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise training modulates biochemical parameters in type 2 diabetic patients with chronic hepatitis C

2017

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Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus

Abstract: Patients with CH-C could safely walk as aerobic exercise. Furthermore, walking improved insulin resistance and decreased body fat while lowering serum levels of leptin.

Cited by 38 publications

References 40 publications

Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise?

Aerobic exercise training modulates biochemical parameters in type 2 diabetic patients with chronic hepatitis C

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