Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial

Bilek, Furkan; Cetisli-Korkmaz, Nilufer; Ercan, Zübeyde; Deniz, Gülnihal; Demir, Caner Feyzi

doi:10.1016/j.msard.2022.103742

Cited by 21 publications

(7 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with our hypothesis, recent data have shown that after exercise, patients affected by other diseases showed increased serum irisin levels and improvement in depression and fatigue. 29 These findings are further supported by data obtained in young mice showing the effects of irisin in reducing depression and anxiety, 30 , 31 suggesting that irisin could be a viable molecular candidate in influencing mood in MM patients and paving the way for further studies in this field.…”

Section: Introductionmentioning

confidence: 64%

Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma

Zerlotin,

Oranger,

Pignataro

et al. 2024

JBMR Plus

View full text Add to dashboard Cite

Bone disease (BD) associated with multiple myeloma (MM) is characterized by osteolytic lesions and pathological fractures, which remain a therapeutic priority despite new drugs improving MM patient survival. Antiresorptive molecules represent the main option for the treatment of MMBD whereas osteoanabolic molecules are under investigation. Among these latter, we here focused on the myokine irisin, able to enhance bone mass in healthy mice, prevent bone loss in osteoporotic mouse models, and accelerate fracture healing in mice. Therefore, we investigated irisin effect on MMBD in a mouse model of MM induced by intratibial injection of myeloma cells followed by weekly administration of 100 μg/Kg of recombinant-irisin for 5 weeks. By micro-Ct analysis, we demonstrated that irisin improves MM-induced trabecular bone damage by partially preventing the reduction of femur Trabecular Bone Volume/Total Volume (p = 0.0028), Trabecular Number (p = 0.0076), and Trabecular Fractal Dimension (p = 0.0044), and increasing Trabecular Separation (p = 0.0003) in MM mice. In cortical bone, irisin downregulates the expression of Sclerostin, the bone formation inhibitor, and RankL, the pro-osteoclastogenic molecule, and in bone marrow (BM) upregulates Opg, the anti-osteoclastogenic cytokine. We found that in the BM tibia of irisin-treated MM mice, the percentage of MM cells displays a reduction trend, while in the femur it decreases significantly. This is in line with the in vitro reduction of myeloma cell viability after 48 hours of irisin stimulation at both 200 and 500 ng/ml and after 72 hours already at 100 ng/ml rec-irisin. These results could be due to irisin ability to downregulate the expression of Notch 3, important for cell-to-cell communication in the tumor niche, and Cyclin D1, regulator of cell cycle progression, supporting an inhibitory effect of irisin in MM cell proliferation. Overall, our findings suggest that irisin could be a new promising strategy to counteract MMBD and tumor burden in one shot.

show abstract

Section: Introductionmentioning

confidence: 64%

Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma

Zerlotin,

Oranger,

Pignataro

et al. 2024

JBMR Plus

View full text Add to dashboard Cite

show abstract

“…These are a series of motions of increasing difficulty to facilitate the restoration of coordination intended to improve rhythmic, smooth, coordinated movements. FCEs have been shown to reliably reduce fatigue in the MS population and may be extended to treat fatigue related to long COVID [144].…”

Section: Musculoskeletal Long Covidmentioning

confidence: 99%

Multidisciplinary Management Strategies for Long COVID: A Narrative Review

Prusinski,

Yan,

Klasova

et al. 2024

Cureus

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of infections to date and has led to a worldwide pandemic. Most patients had a complete recovery from the acute infection, however, a large number of the affected individuals experienced symptoms that persisted more than 3 months after diagnosis. These symptoms most commonly include fatigue, memory difficulties, brain fog, dyspnea, cough, and other less common ones such as headache, chest pain, paresthesias, mood changes, muscle pain, and weakness, skin rashes, and cardiac, endocrine, renal and hepatic manifestations. The treatment of this syndrome remains challenging. A multidisciplinary approach to address combinations of symptoms affecting multiple organ systems has been widely adopted. This narrative review aims to bridge the gap surrounding the broad treatment approaches by providing an overview of multidisciplinary management strategies for the most common long COVID conditions.

show abstract

“…For example, in Multiple Sclerosis, exercise is thought to reduce fatigue by reducing the levels of the muscle derived hormone, irisin. 79 Aerobic exercise alone, or in combination with resistance training or cognitive training, may be helpful in reducing PSF (keeping in mind that the “doses of rehabilitation” have typically been too low to engage neuroplasticity mechanisms important for post-stroke motor recovery). 80,81 Careful titration of dose will be required in PSF patients who are either deconditioned and/or exercise intolerant.…”

Section: Exercise As a Possible Intervention For Psfmentioning

confidence: 99%

Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable

Kuppuswamy,

Billinger,

Coupland

et al. 2023

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Background Post-stroke fatigue (PSF) is a significant and highly prevalent symptom, whose mechanisms are poorly understood. The third Stroke Recovery and Rehabilitation Roundtable paper on PSF focussed primarily on defining and measuring PSF while mechanisms were briefly discussed. This companion paper to the main paper is aimed at elaborating possible mechanisms of PSF. Methods This paper reviews the available evidence that potentially explains the pathophysiology of PSF and draws parallels from fatigue literature in other conditions. We start by proposing a case for phenotyping PSF based on structural, functional, and behavioral characteristics of PSF. This is followed by discussion of a potentially significant role of early inflammation in the development of fatigue, specifically the impact of low-grade inflammation and its long-term systemic effects resulting in PSF. Of the many neurotransmitter systems in the brain, the dopaminergic systems have the most evidence for a role in PSF, along with a role in sensorimotor processing. Sensorimotor neural network dynamics are compromised as highlighted by evidence from both neurostimulation and neuromodulation studies. The double-edged sword effect of exercise on PSF provides further insight into how PSF might emerge and the importance of carefully titrating interventional paradigms. Conclusion The paper concludes by synthesizing the presented evidence into a unifying model of fatigue which distinguishes between factors that pre-dispose, precipitate, and perpetuate PSF. This framework will help guide new research into the biological mechanisms of PSF which is a necessary prerequisite for developing treatments to mitigate the debilitating effects of post-stroke fatigue.

show abstract

Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial

Cited by 21 publications

References 45 publications

Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma

Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma

Multidisciplinary Management Strategies for Long COVID: A Narrative Review

Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable

Contact Info

Product

Resources

About