Aerobic exercise increases sprouting angiogenesis in the male rat motor cortex

Stevenson, Morgan E.; Miller, Chelsea C.; Owen, Heather A.; Swain, Rodney A.

doi:10.1007/s00429-020-02100-y

Cited by 8 publications

(4 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It refers to the Additional experiment 2. We used adult males only as in accordance with many studies (Takimoto and Hamada 2014;Afzalpour et al 2015;Nokia et al 2016;Stevenson et al 2020;Constans et al 2021) because this aim was to avoid ovarian cycle influence on both performance and expression of neuroplasticity markers. Moreover, these sensorimotor tests were randomly conducted with a 10-min rest interval.…”

Section: Animalsmentioning

confidence: 99%

“…Indeed, late increases in hippocampal BDNF concentrations were reported after voluntary running-wheel in healthy rats without changes at earlier stages (Berchtold et al 2005). However, the related timedependent effects of exercise regimens on sensorimotor and endurance performances remain unclear (Berchtold et al 2010;Takimoto and Hamada 2014;Cabral et al 2019;Stevenson et al 2020). The relationship between neurotrophic factors and functional outcomes was mainly established after motor skill training in which an increase in neurotrophic factor expression preceded cortical map reorganization and motor skill improvements (Adkins et al 2006).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Time-dependent cortical plasticity during moderate-intensity continuous training versus high-intensity interval training in rats

et al. 2022

View full text Add to dashboard Cite

The temporal pattern of cortical plasticity induced by high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) is required to clarify their relative benefits to prevent neurological disorders. The purpose of this study is to define the time-dependent effects of work-matched HIIT and MICT on cortical plasticity, endurance, and sensorimotor performances over an 8-week training period in healthy rats. Adult healthy rats performed incremental exercise tests and sensorimotor tests before and at 2, 4, and 8 weeks of training. In parallel, cortical markers related to neurotrophic, angiogenic, and metabolic activities were assessed. Results indicate that HIIT induced an early and superior endurance improvement compared to MICT. We found significant enhancement of speed associated with lactate threshold (SLT) and maximal speed (Smax) in HIIT animals. MICT promoted an early increase in brain-derived neurotrophic factor and angiogenic/metabolic markers but showed less influence at 8 weeks. HIIT upregulated the insulin-like growth factor-1 (IGF-1) as well as neurotrophic, metabolic/angiogenic markers at 2 and 8 weeks and downregulated the neuronal K-Cl cotransporter KCC2 that regulates GABAA-mediated transmission. HIIT and MICT are effective in a time-dependent manner suggesting a complementary effect that might be useful in physical exercise guidelines for maintaining brain health.

show abstract

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Time-dependent cortical plasticity during moderate-intensity continuous training versus high-intensity interval training in rats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Four weeks of voluntary wheel running demonstrated that sprouting angiogenesis is the main form of structural vascular plasticity that is detected in the motor cortex of rats, which is measured by vascular corrosion casts and resin replicas of the brain vasculature. In addition, increased capillary diameter and expanded endothelial cell nuclei diameters are observed in rats after exercise ( Stevenson et al, 2020b ).…”

Section: Exercise and Restoration Of Neurovascular Unitmentioning

confidence: 99%

Neuroprotective Effect of Physical Activity in Ischemic Stroke: Focus on the Neurovascular Unit

Zhang

Xie

2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Cerebral ischemia is one of the major diseases associated with death or disability among patients. To date, there is a lack of effective treatments, with the exception of thrombolytic therapy that can be administered during the acute phase of ischemic stroke. Cerebral ischemia can cause a variety of pathological changes, including microvascular basal membrane matrix, endothelial cell activation, and astrocyte adhesion, which may affect signal transduction between the microvessels and neurons. Therefore, researchers put forward the concept of neurovascular unit, including neurons, axons, astrocytes, microvasculature (including endothelial cells, basal membrane matrix, and pericyte), and oligodendrocytes. Numerous studies have demonstrated that exercise can produce protective effects in cerebral ischemia, and that exercise may protect the integrity of the blood-brain barrier, promote neovascularization, reduce neuronal apoptosis, and eventually lead to an improvement in neurological function after cerebral ischemia. In this review, we summarized the potential mechanisms on the effect of exercise on cerebral ischemia, by mainly focusing on the neurovascular unit, with the aim of providing a novel therapeutic strategy for future treatment of cerebral ischemia.

show abstract

“…However, in vivo imaging and analysis is technically difficult, relationships between stimuli and cerebrovascular plasticity are not always so clear, and studies require large sample sizes to establish statistical significance, which may be intractable without automated assistance. As an example, many endpoint studies in rodents reveal that maintained physical activity encourages at least temporary increases in microvascular density in the motor cortex and hippocampus [31,50,12,52,48]. However, no difference was identified between mice housed with monitored exercise wheels and a control group in a chronic in vivo evaluation performed by [17] using manual vessel tracing.…”

Section: Introductionmentioning

confidence: 99%

Microvascular plasticity in stroke recovery: Longitudinal snapshots, network statistical analysis, and dynamics

Mihelic

Engelmann

Sadr

et al. 2023

Preprint

View full text Add to dashboard Cite

This research article quantitatively investigates neuro-microvascular network remodeling dynamics following stroke using a novel in vivo two-photon angiography (cubic millimeter volume, weekly snapshots) and high throughput (thousands of connected capillaries) vascular vectorization method. The results suggest distinct temporal patterns of cerebrovascular plasticity, with acute remodeling peaking at one week post-stroke. The network architecture then gradually stabilizes, returning to a new steady state after four weeks. These findings align with previous literature on neuronal plasticity, highlighting the correlation between neuronal and neurovascular remodeling. Quantitative analysis of neurovascular networks using length- and strand-based statistical measures reveals intricate changes in network anatomy and topology. The distance and strand-length statistics show significant alterations, with a peak of plasticity observed at one week post-stroke, followed by a gradual return to baseline. The orientation statistic plasticity peaks at two weeks, gradually approaching the (conserved across subjects) stroke signature. The underlying mechanism of the vascular response (angiogenesis vs. tissue deformation), however, is yet unelucidated, requiring network registration advancements. Overall, the combination of two-photon angiography, vectorization, reconstruction/visualization, and statistical analysis enables both qualitative and quantitative assessments of neurovascular remodeling dynamics, demonstrating an impactful method for investigating neuro-microvascular network disorders and the therapeutic modes of action thereof. Understanding the timing and nature of neurovascular remodeling allows for optimized interventions, including personalized medicine for stroke rehabilitation. Additionally, the evaluation of pharmaceutical interventions using these tools may facilitate targeted drug development. Furthermore, neurovascular coupling dynamics have implications for neurodegenerative diseases, brain aging, and the field of brain-computer interfaces.

show abstract

Aerobic exercise increases sprouting angiogenesis in the male rat motor cortex

Cited by 8 publications

References 113 publications

Time-dependent cortical plasticity during moderate-intensity continuous training versus high-intensity interval training in rats

Time-dependent cortical plasticity during moderate-intensity continuous training versus high-intensity interval training in rats

Neuroprotective Effect of Physical Activity in Ischemic Stroke: Focus on the Neurovascular Unit

Microvascular plasticity in stroke recovery: Longitudinal snapshots, network statistical analysis, and dynamics

Contact Info

Product

Resources

About