Aerobic exercise inhibits obesity-induced respiratory phenotype

Aquino‐Junior, Jefferson Comin Jonco; MacKenzie, BreAnne; Almeida-Oliveira, Ana Roberta; Martins, Ana Carolina; Oliveira-Júnior, Manoel Carneiro; Britto, Auriléa Aparecida; Arantes-Costa, Fernanda Magalhães; Damaceno-Rodrigues, Nilsa Regina; Caldini, Élia Garcia; Oliveira, Ana Paula Ligeiro de; Guadagnini, Dioze; Leiria, Luiz O.; Ricardo, Djalma Rabelo; Saad, Mário José Abdalla

doi:10.1016/j.cyto.2017.12.025

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…The functional and structural alterations observed in the lungs (airways and parenchyma), in older adults with MS suggest that the lung may be a potential target organ in older adults in the setting of MS. The increases in airway and tissue resistance in the lungs, indicating the process of remodeling, is characterized by the accumulation of extracellular matrix proteins (collagen, elastin, proteoglycans, laminins) and reflect the structural and functional alterations in the lungs 9 . The alterations of the inflammatory milieu in the lungs are considered a causative factor in its remodeling process 9 , 15 .…”

Section: Discussionmentioning

confidence: 99%

“…The increases in airway and tissue resistance in the lungs, indicating the process of remodeling, is characterized by the accumulation of extracellular matrix proteins (collagen, elastin, proteoglycans, laminins) and reflect the structural and functional alterations in the lungs 9 . The alterations of the inflammatory milieu in the lungs are considered a causative factor in its remodeling process 9 , 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have also reported correlations between systemic inflammation and reduced pulmonary function 8 . A recent pre-clinical study showed that obesity induced the development of a specific pro-inflammatory and pro-fibrotic lung phenotype, which might alter lung function 9 , suggesting the potential obesity-related alterations in lung function. In the present study, we tested the hypothesis that in older adults with MS, the pro-inflammatory and pro-fibrotic responses in the respiratory system may enhance the loss of pulmonary function and impaired lung mechanics.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary function changes in older adults with and without metabolic syndrome

Brandão-Rangel

Moraes-Ferreira

Oliveira-Júnior

et al. 2021

Sci Rep

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The low-grade inflammation associated with metabolic syndrome (MS) triggers functional and structural alterations in several organs. Whereas lung function impairment is well reported for older adult population, the effect of MS on functional and immunological responses in the lungs remains unclear. In this cross-sectional study we determined whether MS alters pulmonary function, and immunological responses in older adults with MS. The study sample consisted of older adults with MS (68 ± 3 years old; n = 77) and without MS (67 ± 3 years old; n = 77). Impulse oscillometry was used to evaluate airway and tissue resistance, and reactance. Biomarkers of inflammation and fibrosis were assessed in the blood and in breath condensate. The total resistance of the respiratory system (R5Hz; p < 0.009), and the resistance of the proximal (R20Hz; p < 0.001) and distal (R5Hz–R20Hz; p < 0.004) airways were higher in MS individuals compared to those without MS. Pro-inflammatory (leptin, IL-1beta, IL-8, p < 0.001; TNF-alpha, p < 0.04) and anti-inflammatory cytokines (adiponectin, IL-1ra, IL-10, p < 0.001), anti-fibrotic (relaxin 1, relaxin 3, Klotho, p < 0.001) and pro-fibrotic (VEGF, p < 0.001) factors were increased in sera and in breath condensate individuals with MS. The results show that MS adversely affect lung mechanics, function, and immunological response in older adults. The data offer a metabolic basis for the inflammaging of the lungs and suggest the lungs as a potential therapeutic target for controlling the immune response and delaying the onset of impaired lung function in older adults with MS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pulmonary function changes in older adults with and without metabolic syndrome

Brandão-Rangel

Moraes-Ferreira

Oliveira-Júnior

et al. 2021

Sci Rep

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“…A possible positive effect of physical exercise in people with sarcoidosis is likely to be complex and depend on several pathways. Experimental studies performed on mice have shown that training induces alterations in peripheral blood lymphocyte subpopulations [35] and in mice with obesityrelated airway hyper-responsiveness, training induced a reduction of several inflammatory cells (including lymphocytes) as well as pro-inflammatory cytokines in BALF [36]. T regulatory cells (T regs ) normally dampen the release of proinflammatory cytokines and thereby have a potential function in controlling and ending immune responses.…”

Section: Discussionmentioning

confidence: 99%

High-intensity resistance training in newly diagnosed sarcoidosis- an exploratory study of effects on lung function, muscle strength, fatigue, dyspnea, health-related quality of life and lung immune cells

Kullberg

Rivera

Eriksson

et al. 2020

European Clinical Respiratory Journal

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“…The practice of regular physical exercise has beneficial effects for the integral health of the human being, in the physical sphere (Comin et al, 2018;Liu et al, 2018;Foright et al, 2018;Wiklund, 2016), mental (Colledge et al, 2018;Alonso-Patiño et al, 2013;Revnic et al, 2013) and socio-affective (Baillot et al, 2018;Rammant et al, 2017;Womble et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The most effective physical exercise to reduce burnout syndrome in university students

Ricardo¹,

Montoro-Bombú²,

Ferreira³

2020

Journal of Human Sport and Exercise - 2020 - Spring Conferences of Sports Science

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The objective of this study was to determine the most effective physical exercise in reducing burnout syndrome levels in university students. Methods: An experimental study was carried with 2 intervention groups with aerobic and strength exercise and one control group without exercise. Instruments: Maslach Burnout Inventory Students Survey and Heart Rate Variability (HRV): RR mean, SDNN, and RMSSD. Results: In exhaustion there was the greatest percentage of change in the aerobics group with a reduction of 26 %, followed by the strength group (19.5 %). In the cynicism it was the strength group that had the greatest reduction (27%) over the aerobics group (21%). Comparison between groups of aerobics and strength: dimension effectiveness low (d = 0.284, PD = 10.51 %), in exhaustion and cynicism trivial (d = 0.068, PD = 4.83 %; and 0.030, 3.39 %). In HRV three variables with trivial effect size (d = 0.071, 0.85%; 0.177, 5.22% and 0.075, 2.95%). HRV behaved differently: RR mean, the difference was large (d = 0.905, 10.24%), in SDNN it was moderate (d = 0.515, 14.48%), whereas in RMSSD it was small. Conclusions: Aerobic exercises were more effective in reducing levels of exhaustion, while strength exercises reduced levels of the cynicism and effectiveness dimensions.

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Aerobic exercise inhibits obesity-induced respiratory phenotype

Abstract: Aerobic exercise reduces high fat diet-induced obese lung phenotype (AHR, pulmonary remodeling and inflammation), involving anti-inflammatory cytokine IL-10 and adiponectin.

Cited by 10 publications

References 24 publications

Pulmonary function changes in older adults with and without metabolic syndrome

Pulmonary function changes in older adults with and without metabolic syndrome

High-intensity resistance training in newly diagnosed sarcoidosis- an exploratory study of effects on lung function, muscle strength, fatigue, dyspnea, health-related quality of life and lung immune cells

The most effective physical exercise to reduce burnout syndrome in university students

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