2018
DOI: 10.1016/j.celrep.2018.04.111
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Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Abstract: SUMMARYAerobic glycolysis accounts for ~80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear. Here, we further established the role of aerobic glycolysis in murine rod and cone PRs. We show that loss of hexokinase-2 (HK2), a key aerobic glycolysis enzyme, does not affect PR survival or structure but is required for normal rod function. Rods with HK2 loss increase their mitochondrial number, suggesting an adaptation to the i… Show more

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Cited by 99 publications
(156 citation statements)
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References 62 publications
(102 reference statements)
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“…2b). 26,27 Additionally, WT retinas express low levels of HK1 in photoreceptor inner segments (Fig. 2c) with the vast majority of HK1 expressed in other cells within the retina.…”
Section: Resultsmentioning
confidence: 96%
See 2 more Smart Citations
“…2b). 26,27 Additionally, WT retinas express low levels of HK1 in photoreceptor inner segments (Fig. 2c) with the vast majority of HK1 expressed in other cells within the retina.…”
Section: Resultsmentioning
confidence: 96%
“…Similar to a previous report, we observed rod dysfunction in older Hk2 cKO mice as measured by ERG. 30 The functional phenotype identified by Petit and colleagues was not associated with any morphological change in retinal structure. In contrast, we show that rod ERG dysfunction was associated with significant outer retinal abnormalities anatomically.…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Therefore, in some tissues where energy requirements are lower, the cells are not diseased, whereas in others with high ATP demand, the mutant load may be high enough to cause disease e.g. retinitis pigmentosa (Petit et al, 2018). The complexity and difficulty in studying mitochondrial diseases emphasises the need for a simpler model organism such as Dictyostelium discoideum to clarify these complex phenotypes and provide the basis for investigating the signalling pathways involved and the downstream cellular consequences.…”
Section: Mitochondrial Disease Modelling In Dictyostelium Mitochondrimentioning
confidence: 99%
“…5,9,10 Furthermore, aerobic glycolysis and its key enzymes have been shown to be important for the function and survival of rod and cone photoreceptors under baseline conditions and confer a survival advantage to photoreceptors during periods of outer retinal stress. 4,1114…”
Section: Introductionmentioning
confidence: 99%