Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity

Haram, Per Magnus; Kemi, Ole Johan; Lee, Sang Jun; Bendheim, Marianne Ø; Al-Share, Qusai Y.; Waldum, Helge L.; Gilligan, Lori J.; Koch, Lauren G.; Britton, Steven L.; Najjar, Sonia M.; Wisløff, Ulrik

doi:10.1093/cvr/cvn332

Cited by 170 publications

(172 citation statements)

References 41 publications

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“…Specifically, HIT has been shown to improve insulin sensitivity and glycaemic control (Burgomaster et al 2006(Burgomaster et al , 2008Gibala et al 2006;Wisloff et al 2007;Tjonna et al 2008;Babraj et al 2009;Haram et al 2009;Nybo et al 2010;Richards et al 2010;Whyte et al 2010;Gaesser and Angadi. 2011;Hood et al 2011;Little et al 2011;Shepherd et al 2013) as well as other cardiovascular health factors (Fletcher et al 1996) after just two weeks of training (typically six training sessions).…”

Section: Introductionmentioning

confidence: 99%

The impact of high-intensity intermittent exercise on resting metabolic rate in healthy males

et al. 2013

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High intensity intermittent exercise training (HIT) may favourably alter body composition despite low training volumes and predicted energy expenditure (EE). Purpose: to characterise the acute impact of two common HIT protocols on EE and post-exercise oxygen consumption (11 h EPOC). Methods: oxygen consumption (l·min -1 ), respiratory exchange ratio (RER) and EE were measured in nine healthy, lean males over 12 h under three conditions: control (CON), HIT1 (10x one min high intensity cycling bouts followed by one min rest) and HIT2 (10x four min high intensity cycling bouts followed by two min rest). Results: total exercise period EE during HIT1 (1151 ± 205 kJ) (mean ± SD) was significantly lower than HIT2 (2788 ± 322 kJ; p < 0.001). EE within the 60 min after exercise was significantly albeit marginally higher after HIT1 (388 ± 44 kJ; p = 0.02) and HIT2

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Section: Introductionmentioning

confidence: 99%

The impact of high-intensity intermittent exercise on resting metabolic rate in healthy males

et al. 2013

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“…A síndrome metabólica é uma desordem multigenética que abrange várias anormalidades, tais como, obesidade visceral, resistência a insulina, hipertensão arterial, dislipidemia e alteração no controle glicêmico (hARAM et al, 2009). O risco de doença coronária é maior em pessoas sedentárias do que naquelas que são ativas fisicamente, além disso, a inatividade física pode contribuir para hipertensão arterial e baixos níveis de lipoproteína de alta densidade (hDL colesterol) e hipertrigliceridemia, fatores estes associados com doença aterosclerótica (GUERRA et al, 2007).…”

Section: Introductionunclassified

Perfil lipídico e glicêmico de ratos treinados em exercício aeróbio ou anaeróbio e suplementados com maltodextrina

Leite¹,

Hartleben²,

Magalhães³

et al. 2013

Rev. Bras. Ciênc. Esporte

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“…Because of insufficient information regarding the health effects of HIIT on OGG1 and 8-OHdG, the results of present study will give new insights about HIIT. Especially, greater stress oxidative occurs during HIIT due to activation of NADPH oxidase (Haram et al, 2009), xanthine oxidase (Kostaropoulos et al, 2006), and hypoxic conditions (Rasmussen et al, 2009). In addition, liver and brain are considered as redox sensitive organs in body due to large number of mitochondria, ischemia/reperfusion of blood (Cooper et al, 2002, Lamprecht et al, 2004 and large amounts of iron and copper ions (Cooper et al, 2002, Urso et al, 2003.…”

Section: Introductionmentioning

confidence: 99%

Effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2-deoxyguanosine contents in the brain and liver of rats

Afroozi-Gerow¹,

Afzalpour²,

TaheriChadorneshin³

et al. 2016

J App Pharm Sci

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Production of reactive oxygen species (ROS) yields serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. This study aimed to investigate the effect of high intensity interval training on 8-oxoguanine DNA glycosylase (OGG1) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the brain and liver of rats. 16 adult Albino Wistar rats were randomly divided into sedentary control and high intensity interval training groups. Animals ran on treadmill for 6 weeks, 6 days per week, at 95 to 100 percent of maximal oxygen consumption. Using commercial kits, the content of OGG1 and 8-OHdG were measured using sandwich ELISA assay. Data analyzed using Student's Ttest at P≤0.05 level. High intensity interval training resulted in significant increases in contents of OGG1 in brain (t14=7.22, P=0.001) and liver (t14=2.55, P=0.02) of rats. However, high intensity interval training had no significant influence on 8-OHdG levels in brain (t14=1.60, P=0.13) and liver (t14=1.28, P=0.22) of rats. Also, there were no significant differences between changes in the brain and liver contents of OGG1 (t14=0.97, P=0.34) and 8-OHdG (t14=0.42, P=0.68) of rats following high intensity interval training. Taken together, separation of the training sessions to various bouts of exercise with maximum effort, through increase in OGG1 contents, will lead to modify of 8-OHdG levels in brain and liver.

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Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity

Cited by 170 publications

References 41 publications

The impact of high-intensity intermittent exercise on resting metabolic rate in healthy males

The impact of high-intensity intermittent exercise on resting metabolic rate in healthy males

Perfil lipídico e glicêmico de ratos treinados em exercício aeróbio ou anaeróbio e suplementados com maltodextrina

Effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2-deoxyguanosine contents in the brain and liver of rats

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