Aerobic Oxidative Heck/Dehydrogenation Reactions of Cyclohexenones: Efficient Access to meta‐Substituted Phenols

Insertion of ammonia into alkenes to build aromatic N-heterocycles

“…Such an intrinsic obstacle makes the direct insertion of heteroatoms into alkenes to build heterocycles an elusive goal. To regulate the oxidation state of organic molecules, the dehydrogenation reaction is a complementary route to the oxygenation reaction [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Dehydrogenative cross-coupling exhibits a unique ability to achieve oxidative bond formation in the absence of external oxidants [22][23][24][25][26] .…”

A Biomimetic Catalytic Aerobic Functionalization of Phenols

“…Our method embodies a growing trend in synthetic chemistry, which aims to drive CH bond functionalization by the concomitant formation of water 36. The use of phenols as starting materials for this class of reactions is noteworthy, given their potential to become renewable feedstock chemicals10 and their recent synthesis by catalytic aerobic methods 9a,b. Our study benefits from operational simplicity (room temperature, open flask, Earth‐abundant catalyst, commercial reagents, single reaction vessel) and highlights how biomimetic catalysis can have an impact on the development of environmentally friendly methods for chemical synthesis 1.…”

Arthur C. Cope Scholar Awards: W. R. Dichtel, M. Fujita, M. J. Krische, D. S. Matteson, B. S. Moore, T. W. Muir, J. R. Norton, S. E. Reisman, M. F. Semmelhack, S. S. Stahl

“…Im Mittelpunkt seiner Forschung steht die Übergangsmetallkatalyse, vor allem katalytische aerobe Oxidationen und die elektrokatalytische Sauerstofferzeugung. In seinen neuesten Beiträgen in der Angewandten Chemie geht es um die Beziehung zwischen Nucleopalladierungswegen und der Enantioselektivität von katalytischen Reaktionen8a sowie um aerobe oxidative Heck‐Reaktionen/Dehydrierungen 8b…”