Aerobic training and L-arginine supplement attenuates myocardial infarction-induced kidney and liver injury in rats via reduced oxidative stress

Ranjbar, Kamal; Nazem, Farzad; Sabrinezhad, Reyhaneh; Nazari, Afshin

doi:10.1016/j.ihj.2017.08.011

Cited by 15 publications

(13 citation statements)

References 40 publications

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“…23 Additionally, studies have shown that exercise reduced serum creatinine and proteinuria in male rats with kidney disease 4,22,26 and reduced serum urea in animals with kidney disease induced by acute myocardial infarction with significant improvement in renal function. 27 The beneficial effects of physical exercise can be attributed to the reduction of hyperglycemia, oxidative stress, and improved bioavailability of nitric oxide in diabetic animals. 20,22,24,41 In this sense, Francescato et al 25 demonstrated that physical preconditioning animals exhibited increased expression of pp-eNOS and eNOS, possibly indicating preserved endothelial function, and increased NO levels in renal tissue, which may have contributed to the reduction of the vasoconstrictor effect and of the inflammatory process in a model of cisplatin-induced acute renal injury.…”

Section: Discussionmentioning

confidence: 99%

“…61 Exercise also increased eNOS staining in the aorta and reduced neutrophil accumulation and lipid peroxidation in rats with renovascular hypertension. 62 Furthermore, it was demonstrated that aerobic exercise ameliorated kidney 27 and liver 63 dysfunction via reduction of malondialdehyde levels.…”

Section: Discussionmentioning

confidence: 99%

“…23,24 Recent studies have also shown that physical preconditioning was effective in reducing renal damage in a model of acute 25 and chronic 26 renal injury. Furthermore, Ranjbar et al 27 demonstrated that exercise improved renal and hepatic damage in rats with myocardial infarction. Additionally, Souza et al 28 showed that exercise improved autonomic function and reduced mortality in ovariectomized diabetic rats.…”

Section: Impact Statementmentioning

confidence: 99%

“…Furthermore, Ranjbar et al . 27 demonstrated that exercise improved renal and hepatic damage in rats with myocardial infarction. Additionally, Souza et al.…”

Section: Introductionmentioning

confidence: 99%

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Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes

Souza

Oliveira

Viana

et al. 2019

Exp Biol Med (Maywood)

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This study evaluated the effects of moderate regular physical exercise on lipid peroxidation, inflammation and renal function and structure in streptozotocin (STZ)-induced ovariectomized diabetic rats. Twenty-four Wistar rats were anesthetized and submitted to bilateral ovariectomy. The rats were divided into four experimental groups: ovariectomized control (OC), ovariectomized trained control (OTC), ovariectomized diabetic (OD), ovariectomized trained diabetic (OTD). The OTD and OTC groups were submitted to treadmill running for four weeks before to diabetes mellitus (DM) induction with STZ (40 mg/kg, i.v) or vehicle injection, respectively, and continued the training for another eight weeks after the injections. Urine samples were collected 24 h after the last training session, and blood samples and kidneys were collected after euthanasia. Our results showed that physical exercise attenuated the loss of body weight and postprandial glucose and improved physical capacity in the OTD group. Lower serum creatinine levels, glycosuria, and proteinuria were also observed in this group. There was no difference in 17β-estradiol levels between the experimental groups. The glomerular and tubulointerstitial changes were attenuated in the OTD group. Expressions of macrophages, lymphocytes, fibronectin, TGF-β1, and NF-κB were reduced in the glomeruli of OTD group. Exercise also reduced macrophages, lymphocytes, and TGF-β1 expression in the tubulointerstitial compartment of the renal cortex of this group. In addition, increased levels of TBARS in the renal cortex of diabetic rats were prevented by exercise in the OTD group. In conclusion, our study shows that physical exercise exerted a renoprotective effect against the progression of diabetic kidney disease in ovariectomized rats. Impact statement To date, no studies have been found evaluating the effects of physical exercise on renal function and structure changes in ovariectomized rats with type 1 diabetes. Therefore, this work emerges with an important tool for strengthening and expanding innovative research on exercise with potential for the prevention of renal diseases in ovariectomized diabetic rats, and future development of studies that seek to increase scientific knowledge about the beneficial effects of physical exercise on renal diseases in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Impact Statementmentioning

confidence: 99%

“…Furthermore, Ranjbar et al . 27 demonstrated that exercise improved renal and hepatic damage in rats with myocardial infarction. Additionally, Souza et al.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes

Souza

Oliveira

Viana

et al. 2019

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…In a rat model, aerobic interval exercise protocol was shown to prevent the development of diabetic nephropathy and to affect the metabolism of certain minerals [12]. Moreover, aerobic training in association with L-arginine supplementation also demonstrated to ameliorate kidney and liver damage in myocardial infarction rats, via antioxidant mechanisms [13]. The expression of many cytokines and adipokines associated with metabolic syndrome has also been investigated in obese women, after aerobic training protocol, with positive results [14].…”

Section: Introductionmentioning

confidence: 99%

Adapted Moderate Training Exercise Decreases the Expression of Ngal in the Rat Kidney: An Immunohistochemical Study

et al. 2019

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Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of several injuries and is upregulated in inflammatory conditions. Vitamin D was shown to have anti-inflammatory effects and to increase after physical activity. This work aimed to assess, through immunohistochemistry, the effects of an adapted moderate training exercise (AMTE) on the expression of NGAL and vitamin D receptor (VDR) in the kidney and heart of rats. Sixteen rats were distributed into two groups: the sedentary control group and the experimental group, subjected to AMTE on the treadmill for 12 weeks. The results showed the basal expression of NGAL and VDR in both the heart and the kidney in sedentary rats; no differences in the expression of both NGAL and VDR in the heart; and a decreased NGAL and an increased VDR expression in the kidney of rats subjected to AMTE. These results suggest a possible protective role of AMTE on NGAL-associated injuries in the kidney, probably through the vitamin D signaling pathway. Our results represent an interesting preliminary data that may open new horizons in the management of NGAL-associated kidney injuries. However, further studies are needed to confirm these results and to comprehend the specific interaction between NGAL and VDR pathways in the kidney.

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Integrated gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐mass spectrometry renal metabolomics and lipidomics deciphered the metabolic regulation mechanism of Gushudan on kidney‐yang‐deficiency‐syndrome rats

Lü

Zhang

Xin

et al. 2023

J of Separation Science

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Kidney‐yang‐deficiency‐syndrome is a neuroendocrine disease caused by the dysfunction of the adrenal‐pituitary‐target gland axis. Gushudan is a traditional Chinese medicine prescription with the functions of tonifying the kidney and strengthening bone, and its bone‐strengthening effect has been confirmed by previous anti‐osteoporosis research. However, its kidney‐tonifying mechanism has not been clear so far. In this study, renal metabolomics and lipidomics based on gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐high resolution mass spectrometry were integrated to find the metabolic disorders in kidney‐yang‐deficiency‐syndrome rats. Protein precipitation and liquid‐liquid extraction were used to extract metabolome and lipidome from the kidney. Gushudan regulated abnormal levels of amino acids, lipids, purines, and carbohydrates, such as L‐arginine, hypoxanine, stearic acid, and phosphatidylethanolamine (P‐18:1/20:4), which had effects on many metabolic pathways, such as glycerophospholipid metabolism, sphingolipid metabolism, glycine, serine and threonine metabolism and purine metabolism, and so forth. By integrating metabolomics and lipidomics, this study comprehensively revealed the abnormal metabolic activities of amino acids, lipids, and nucleotides in kidney‐yang‐deficiency‐syndrome, and the metabolic regulation mechanism of Gushudan in preventing kidney‐yang‐deficiency‐syndrome, as well as the improvement of Gushudan in maintaining renal cell structure, mitochondrial function, and energy supply, which also provided some new evidence and connotation for “kidney‐bone” axis.

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Aerobic training and L-arginine supplement attenuates myocardial infarction-induced kidney and liver injury in rats via reduced oxidative stress

Abstract: These results demonstrated that kidney and liver function impaired 14 weeks after MI and aerobic training and L-arginine supplementation synergistically ameliorated kidneys and liver injury in myocardial infarction rats through oxidative stress reduction.

Cited by 15 publications

References 40 publications

Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes

Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes

Adapted Moderate Training Exercise Decreases the Expression of Ngal in the Rat Kidney: An Immunohistochemical Study

Integrated gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐mass spectrometry renal metabolomics and lipidomics deciphered the metabolic regulation mechanism of Gushudan on kidney‐yang‐deficiency‐syndrome rats

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