Aerobic training (AT) is more effective than aerobic plus resistance training (AT+RT) to improve anorexigenic/orexigenic factors in obese adolescents

Carnier, June; Mello, Marco Túlio de; Ackel-D’Elia, Carolina; Corgosinho, Flávia Campos; Campos, Raquel Munhoz da Silveira; Sanches, Priscila de Lima; Masquio, Deborah Cristina Landi; Júnior, Carlos Roberto Bueno; Ganen, Aline de Piano; Martins, Aniela C.; Caranti, Danielle Arisa; Tock, Lian; Clemente, Ana Paula Grotti; Tufik, Sérgio; Dâmaso, Ana Raimunda

doi:10.1016/j.appet.2013.05.018

Cited by 30 publications

(56 citation statements)

References 23 publications

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“…Despite this result, concurrent exercise in the multidisciplinary context was effective for modulating other important obesity variables involved in metabolic syndrome, nonalcoholic fat liver, bone mineral density, and hyperleptinemia [23-27], thereby justifying why we chose this exercise protocol. It is important to emphasize that despite the results found by Carnier et al [11], we were able to show improvement in body composition and neuroendocrine modulation with this exercise protocol.…”

Section: Discussioncontrasting

confidence: 52%

“…Moreover, in the weight loss protocol, the exercise training was suggested as an important tool for modulation to the anorexigenic/orexigenic pathway. In this perspective, Carnier et al [11] showed how different types of exercises can modulate α-MSH responses, independently of food ingestion, when supported by 1 year of multicomponent weight loss therapy. The aerobic training was able to increase α-MSH levels more than aerobic plus resistance exercise (concurrent training).…”

Section: Discussionmentioning

confidence: 99%

“…However, as we know, this hormone it is not fully investigated in obese adolescents undergoing weight loss therapy [11, 12]. We hypothesized that high concentration of α-MSH at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents.…”

Section: Introductionmentioning

confidence: 99%

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The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

et al. 2018

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Background: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents. Methods: One hundred ten post-pubertal obese adolescents (body mass index >95th percentile) were submitted to 1 year of interdisciplinary therapy (clinical, nutritional, psychological, physical exercise, and physiotherapy support). Body composition and plasma levels of α-MSH, neuropeptide Y (NPY), melanin-concentrating hormone, and agouti-related peptide (AgRP) were measured before and after therapy. The volunteers were grouped on the basis of Tertiles of α-MSH concentration: Low (<0.75 ng/mL), Medium (≤0.76 to ≥1.57 ng/mL), and High (>1.57 ng/mL). Significance was set as p < 0.05. Results: The treatment promoted a significant improvement in body adiposity and fat free mass for all groups. It is important to note that only in the high α-MSH group, a significant increase of the α-MSH/NPY ratio and decrease NPY/AgRP ratio post treatment were observed. Conclusion: The high α-MSH concentration promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents following long-term weight loss therapy and this is important in clinical practice.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

et al. 2018

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“…Baseline group comparison, point estimate and variability can be seen in the supplementary file 3. Eight studies were allocation randomised,24–26 29 31 32 34 35 five used blind assessors,25 26 29 31 35 and four used intention-to-treat analysis 25 26 34 35…”

Section: Resultsmentioning

confidence: 99%

Concurrent aerobic plus resistance exercise versus aerobic exercise alone to improve health outcomes in paediatric obesity: a systematic review and meta-analysis

et al. 2016

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Objective To determine if the combination of aerobic and resistance exercise is superior to aerobic exercise alone for the health of obese children and adolescents. Design Systematic review with meta-analysis. Data sources Computerised search of 3 databases (MEDLINE, EMBASE, and Cochrane Controlled Trials Registry). Eligibility criteria for selecting studies Studies that compared the effect of supervised concurrent exercise versus aerobic exercise interventions, with anthropometric and metabolic outcomes in paediatric obesity (6-18 years old). The mean differences (MD) of the parameters from preintervention to postintervention between groups were pooled using a random-effects model. Results 12 trials with 555 youths were included in the meta-analysis. Compared with aerobic exercise alone, concurrent exercise resulted in greater reductions in body mass (MD=−2.28 kg), fat mass (MD=−3.49%; and MD=−4.34 kg) and low-density lipoprotein cholesterol (MD=−10.20 mg/dL); as well as greater increases in lean body mass (MD=2.20 kg) and adiponectin level (MD=2.59 μg/mL). Differences were larger for longer term programmes (>24 weeks). Summary Concurrent aerobic plus resistance exercise improves body composition, metabolic profiles, and inflammatory state in the obese paediatric population. Trial registration number CRD42016039807.

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“…Further evidence of an inverse relationship between the change in FFM following weight loss and subsequent weight regain in adolescents is needed, as increased FFM may lead to augmented hunger signaling (60) , potentially exacerbated by reductions in the satiety hormone leptin following weight loss (61) . While reductions in energy intake have been observed over the short-term in obese adolescents who gained FFM during treatment (18,60) , the preservation of and/or increases in FFM could bear a negative effect on future dietary habits, as FFM is the strongest predictor of energy intake in adult males (62) . Alternatively, maintenance of body composition at a lower absolute FFM would require less energy intake (63) and result in an increased REE-to-FFM (19) .…”

Section: Ffm and Weight Maintenancementioning

confidence: 96%

The contribution of fat-free mass to resting energy expenditure: implications for weight loss strategies in the treatment of adolescent obesity

Browning

Evans

2015

International Journal of Adolescent Medicine and Health

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Owing to the strong relationship between fat-free mass (FFM) and resting energy expenditure (REE), the preservation of FFM is often emphasized in the treatment of adolescent obesity. Typical treatment regimens including an increased dietary consumption of protein and participation in resistance training are common components of adolescent weight management programs, despite limited evidence of a positive influence of FFM on weight loss outcomes in adolescents. Given the larger volume of FFM in obese relative to normal weight adolescents and the common treatment goals of both maximizing weight loss and attenuating the loss of FFM, a better understanding of the influence of FFM on energy balance is needed to determine whether strategies to preserve lean tissue or maximize absolute weight loss should be most emphasized. We review the associations among FFM, REE, and weight loss outcomes, focusing on how these relationships might influence energy balance in obese adolescents.

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Aerobic training (AT) is more effective than aerobic plus resistance training (AT+RT) to improve anorexigenic/orexigenic factors in obese adolescents

Cited by 30 publications

References 23 publications

The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

Concurrent aerobic plus resistance exercise versus aerobic exercise alone to improve health outcomes in paediatric obesity: a systematic review and meta-analysis

The contribution of fat-free mass to resting energy expenditure: implications for weight loss strategies in the treatment of adolescent obesity

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