Aerobic training prevents oxidative profile and improves nitric oxide and vascular reactivity in rats with cardiometabolic alteration

Medeiros, Renata Jurema; Gaique, Thaiane Gadioli; Bento-Bernardes, Thais; Motta, Nadia Alice Vieira; Brito, Fernanda; Fernandes-Santos, Caroline; Castro-Pinheiro, Camila; Oliveira, Karen Jesus; Nóbrega, Antônio Cláudio Lucas da

doi:10.1152/japplphysiol.00369.2015

Cited by 13 publications

(42 citation statements)

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“…Our study confirms that fructose-fed rats did not develop increased BM compared with the control group (Botezelli et al 2012;Magliano et al 2015). However, the effects of fructose seem, in part, to be independent of increases in BM, because the rats showed liver injuries and subclinical metabolic alterations (Medeiros et al 2016).…”

Section: Discussionsupporting

confidence: 84%

“…It is important to note that the final aerobic capacity was decreased in untrained HFr rats in relationship to CT rats, unlike the exercise-trained HFr rats. Therefore, the exercise training on a motor treadmill, at a moderate intensity during 8 weeks, increased the final maximal speed, suggesting improved aerobic capacity in these exercised-trained animals (Botezelli et al 2012;Medeiros et al 2016). We observed hyperinsulinaemia in the presence of normal glucose concentrations in the HFr group.…”

Section: Discussionmentioning

confidence: 55%

“…However, the effects of fructose seem, in part, to be independent of increases in BM, because the rats showed liver injuries and subclinical metabolic alterations (Medeiros et al . ). It is important to note that the final aerobic capacity was decreased in untrained HFr rats in relationship to CT rats, unlike the exercise‐trained HFr rats.…”

Section: Discussionmentioning

confidence: 97%

“…The test ended when animals were exhausted, i.e. until they were not able to run and remained at the end of the mat even after 10 gentle mechanical stimuli (Brooks & White, 1978;Medeiros et al 2016). No electric shocks were used during the treadmill exercise test.…”

Section: Maximal Treadmill Exercise Testmentioning

confidence: 99%

“…After 2 weeks of water consumption or fructose overloading (CT-Ex and HFr-Ex groups, respectively), the exercise training was initiated and accomplished on a motor treadmill (Inbrasport, RS, Brazil) at a moderateintensity (50-75% of maximal running speed), from 0 to 7% inclination, for 8 weeks, 60 min day −1 and 4 days each week (Medeiros et al 2016).…”

Section: Exercise Training Protocolmentioning

confidence: 99%

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Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Frantz

Medeiros

Giori

et al. 2017

Experimental Physiology

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What is the central question of this study? What are the effects of exercise training on the hepatic renin-angiotensin system and their contribution to damage resulting from fructose overload in rats? What is the main finding and its importance? Exercise training attenuated the deleterious actions of the angiotensin-converting enzyme/angiotensin II/angiotensin II type 1 receptor axis and increased expression of the counter-regulatory (angiotensin-converting enzyme 2/angiotensin (1-7)/Mas receptor) axis in the liver. Therefore, our study provides evidence that exercise training modulates the hepatic renin-angiotensin system, which contributes to reducing the progression of metabolic dysfunction and non-alcoholic fatty liver disease in fructose-fed rats. The renin-angiotensin system (RAS) has been implicated in the development of metabolic syndrome. We investigated whether the hepatic RAS is modulated by exercise training and whether this modulation improves the deleterious effects of fructose overload in rats. Male Wistar rats were divided into (n = 8 each) control (CT), exercise control (CT-Ex), high-fructose (HFr) and exercise high-fructose (HFr-Ex) groups. Fructose-drinking rats received d-fructose (100 g l ). After 2 weeks, CT-Ex and HFr-Ex rats were assigned to a treadmill training protocol at moderate intensity for 8 weeks (60 min day , 4 days per week). We assessed body mass, glucose and lipid metabolism, hepatic histopathology, angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) activity, the angiotensin concentration and the expression profile of proteins affecting the hepatic RAS, gluconeogenesis and inflammation. Neither fructose overload nor exercise training influenced body mass gain and serum ACE and ACE2 activity. The HFr group showed hyperinsulinaemia, but exercise training normalized this parameter. Exercise training was effective in preventing hepatic steatosis and in preventing triacylglycerol and glycogen accumulation. Furthermore, exercise improved the response to the deleterious effects of HFr overload by normalizing the gluconeogenesis pathway and the protein levels of interleukin-6 and tumour necrosis factor-α. The HFr rats displayed increased hepatic ACE activity and protein expression and angiotensin II concentration, which were attenuated by exercise training. Exercise training restored the ACE2/angiotensin-(1-7)/Mas receptor axis. Exercise training may favour the counter-regulatory ACE2/angiotensin-(1-7)/Mas receptor axis over the classical RAS (ACE/angiotensin II/angiotensin II type 1 receptor axis), which could be responsible for the reduction of metabolic dysfunction and the prevention of non-alcoholic fatty liver disease.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 97%

Section: Maximal Treadmill Exercise Testmentioning

confidence: 99%

Section: Exercise Training Protocolmentioning

confidence: 99%

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Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Frantz

Medeiros

Giori

et al. 2017

Experimental Physiology

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Exercise and Vascular Function

Kränkel

Craenenbroeck

Adams

2020

Textbook of Sports and Exercise Cardiology

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Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome

et al. 2017

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Endothelial function is a key mechanism in the development of CVD. Arginine and exercise are important non-pharmacological strategies for mitigating the impact of metabolic changes in the metabolic syndrome, but the effect of their combined administration is unknown. Thus, the aim of this study was to investigate the isolated and combined effects of aerobic training and arginine supplementation on metabolic variables and vascular reactivity in rats at high risk for developing the metabolic syndrome. Wistar rats were divided into two groups: control and fructose (F - water with 10 % fructose). After 2 weeks, the F group was divided into four groups: F, fructose+arginine (FA, 880 mg/kg per d of l-arginine), fructose+training (FT) and fructose+arginine+training (FTA); treatments lasted for 8 weeks, and no difference was observed in body mass gain. Arginine did not improve the body protein content, and both the FA and FT groups show a reversal of the increase in adipose tissue. Insulin increase was prevented by training and arginine, without additive effect, and the increase in serum TAG was prevented only by training. The F group showed impaired endothelium-dependent vasodilation and hyperreactivity to phenylephrine, but arginine and training were capable of preventing these effects, even separately. Higher nitric oxide level was observed in the FA and FT groups, and no potentiating effect was detected. Thus, only training was able to prevent the increase in TAG and improve the protein mass, and training and arginine exert similar effects on fat content, insulin and endothelial function, but these effects are not additive.

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Aerobic training prevents oxidative profile and improves nitric oxide and vascular reactivity in rats with cardiometabolic alteration

Abstract: Aerobic training prevents oxidative profile and improves nitric oxide and vascular reactivity in rats with cardiometabolic alteration.

Cited by 13 publications

References 64 publications

Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Exercise and Vascular Function

Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome

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