Aerobic training reverses airway inflammation and remodelling in an asthma murine model

Abstract

Aerobic training (AT) decreases dyspnoea and exercise-induced bronchospasm, and improves aerobic capacity and quality of life; however, the mechanisms for such benefits remain poorly understood. The aim of the present study was to evaluate the AT effects in a chronic model of allergic lung inflammation in mice after the establishment of airway inflammation and remodelling.Mice were divided into the control group, AT group, ovalbumin (OVA) group or OVA+AT group and exposed to saline or OVA. AT was started on day 28 for 60 min five times per week for 4 weeks. Respiratory mechanics, specific immunoglobulin (Ig)E and IgG 1 , collagen and elastic fibres deposition, smooth muscle thickness, epithelial mucus, and peribronchial density of eosinophils, CD3+ and CD4+, IL-4, IL-5, IL-13, interferon-c, IL-2, IL-1ra, IL-10, nuclear factor (NF)-kB and Foxp3 were evaluated.The OVA group showed an increase in IgE and IgG 1 , eosinophils, CD3+, CD4+, IL-4, IL-5, IL-13, NF-kB, collagen and elastic, mucus synthesis, smooth muscle thickness and lung tissue resistance and elastance. The OVA+AT group demonstrated an increase of IgE and IgG 1 , and reduction of eosinophils, CD3+, CD4+, IL-4, IL-5, IL-13, NF-kB, airway remodelling, mucus synthesis, smooth muscle thickness and tissue resistance and elastance compared with the OVA group (p,0.05). The OVA+AT group also showed an increase in IL-10 and IL-1ra (p,0.05), independently of Foxp3.AT reversed airway inflammation and remodelling and T-helper cell 2 response, and improved respiratory mechanics. These results seem to occur due to an increase in the expression of IL-10 and IL-1ra and a decrease of NF-kB.

Avaliação espirométrica e da hiper-responsividade brônquica de crianças e adolescentes com asma atópica persistente moderada submetidos a natação

“…results suggest that a small amount of physical activity is able to effect a significant reduction in BHR; this could then be added to the growing list of already-known benefits of exercise. Using an experimental model of asthma, an intriguing study by Silva et al 28 showed that physical training can reverse airway inflammation and remodeling and improve respiratory mechanics, consequently reducing BHR. 28 If confirmed, these encouraging results could contribute to the development of programs for the primary prevention of lung disease.…”

Datura metel linn ameliorates asthma symptoms in BALB/c mice

“…People with asthma will increase in levels of T-helper-2 (Th-2) cytokines and undergo chronic airway inflammation and remodeling (Matt et al 2009, Silva et al 2010, Zhang et al 2011. In that condition mast cells develop to an effector phase and produce Th2 cytokines, like IL-4, IL-5, and IL-9.…”

Has Aerobic Exercise Anti-inflammatory Effect for Asthma?

“…In this direction, since 2004 a growing number of experimental studies using mouse models of chronic allergic airway inflammation have demonstrated that low and moderate intensity aerobic exercise performed either before, during or after the allergen sensitization results in decreased eosinophilic inflammation, Th2 cytokines production, airway remodeling and hyperresponsiveness [16][17][18][19][20][21][22][23][24]. Shortly, these studies have demonstrated that these beneficial effects can be attributed to decreased activation of leukocytes and bronchial epithelial cells as a result of increased activation of glucocorticoids receptors, T-regulatory cells resulting in increased synthesis of anti-inflammatory cytokine IL-10, and decreased activation of transcriptional factor NF-kB [16][17][18][19][20][21][22][23][24].…”

“…Shortly, these studies have demonstrated that these beneficial effects can be attributed to decreased activation of leukocytes and bronchial epithelial cells as a result of increased activation of glucocorticoids receptors, T-regulatory cells resulting in increased synthesis of anti-inflammatory cytokine IL-10, and decreased activation of transcriptional factor NF-kB [16][17][18][19][20][21][22][23][24]. In addition, these studies also demonstrated that aerobic exercise present a direct inhibitory effect on the pulmonary oxidants production as well as on the synthesis of mediators involved in the airway remodeling process [19,24].…”