Aerobic vaginitis: no longer a stranger

Donders, Gilbert; Bellen, Gert; Grincevičienė, Švitrigailė; Ruban, Kateryna; Vieira‐Baptista, Pedro

doi:10.1016/j.resmic.2017.04.004

Cited by 186 publications

(242 citation statements)

References 91 publications

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“…These bacteria have often been associated with maternal and neonatal infections (Cools et al, 2016;Black et al, 2018), as well as invasive infections in nonpregnant women such as pelvic inflammatory disease (Brunham et al, 2015). Some clinical researchers have hypothesized that a distinct type of vaginitis (desquamative inflammatory vaginitis), which is characterized by much more severe vaginal inflammation than BV and with desquamation of vaginal epithelial cells including parabasal cells (Sobel, 1994;Paavonen and Brunham, 2018), may be caused by pathobionts in the VMB (Donders et al, 2017). Two cases that appear to have been triggered by toxic shock syndrome toxin-1-producing Staphylococcus aureus strains have indeed been reported (Pereira et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Pathobionts in the Vaginal Microbiota: Individual Participant Data Meta-Analysis of Three Sequencing Studies

Wijgert

Verwijs

Gill

et al. 2020

Front. Cell. Infect. Microbiol.

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Having pathobionts was positively associated with young age, non-Dutch origin, hormonal contraceptive use, smoking, antibiotic use in the 14 days prior to sampling, van de Wijgert et al. Pathobionts in the Vaginal MicrobiotaHIV status, and the presence of sexually transmitted pathogens, in at least one but not all studies; inconsistently associated with sexual risk-taking and unusual vaginal discharge reporting; and not associated with vaginal yeasts detection by microscopy. We recommend that future VMB studies quantify common vaginal pathobiont genera.

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Section: Introductionmentioning

confidence: 99%

Pathobionts in the Vaginal Microbiota: Individual Participant Data Meta-Analysis of Three Sequencing Studies

Wijgert

Verwijs

Gill

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Dysbiotic vaginal colonization by E. coli during pregnancy is clinically important with respect to preterm delivery and neonatal infection. E. coli is the most common Gram‐negative bacteria causing aerobic vaginitis, and also one of the risk factors for PTB (adjusted odd ratio, 2.99; 95% CI, 1.37–6.53) . Moreover, E. coli is the second causative organism of early onset neonatal sepsis (EONS) and meningitis, followed by Streptococcus agalactiae .…”

Section: Discussionmentioning

confidence: 99%

“…E. coli is the most common Gram-negative bacteria causing aerobic vaginitis, and also one of the risk factors for PTB (adjusted odd ratio, 2.99; 95% CI, 1.37-6.53). 17,18 Moreover, E. coli is the second causative organism of early onset neonatal sepsis (EONS) and meningitis, followed by Streptococcus agalactiae. These microorganisms can be transmitted to the newborn through the genital tract, and they can develop consequent neonatal infection.…”

Section: Discussionmentioning

confidence: 99%

Prospective study of bidet toilet use: Association of abnormal vaginal colonization and preterm birth in high‐risk pregnant women

Kim

Lee

et al. 2019

J of Obstet and Gynaecol

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Aim This study aimed to evaluate the association of bidet toilet use with abnormal vaginal microbial colonization and preterm birth (PTB) in high‐risk pregnancies. Methods This is a prospective cohort study of 208 women, who were admitted to a high‐risk pregnancy unit, due to preterm labor, preterm premature rupture of the membrane, or short cervical length, in two tertiary hospitals from April 2015 to July 2017. Responses to a questionnaire about using bidet toilet and vaginal culture were obtained upon admission. Maternal baseline characteristics, vaginal culture results, and pregnancy and neonatal outcomes were compared between bidet toilet users and nonusers. Results Among the 204 subjects, 67 (32.8%) women were identified as bidet toilet users. Overall, bidet toilet use was associated with a higher rate of abnormal vaginal microbial colonization, compared to the nonusers (60.7% vs 44.2%, P = 0.036). Notably, Escherichia coli colonization rate was significantly higher in bidet toilet users than nonusers (13.1% vs 3.3%, P = 0.023). Bidet toilet users had a significantly higher rate of PTB before 37 weeks of gestation, compared to the nonusers (87.3% vs 73.0%, P = 0.040). Conclusion Our study suggests that chronic use of a bidet toilet is associated with a higher rate of abnormal vaginal colonization by Gram‐negative bacteria and PTB in high‐risk pregnancies.

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“…Aerobic vaginitis is largely under-researched and its association with infertility is unclear. However, this condition is an important cause of adverse pregnancy outcomes [24]. There was no significant evidence relating Candida spp.…”

Section: Microbial Infectionmentioning

confidence: 96%

Is genital tract infection related to tubal diseases in infertile Vietnamese women?

Lê

Nguyen

et al. 2019

J Infect Dev Ctries

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Introduction: The goal of this study was to identify the profile of genital tract infections and their relationship with clinical and demographic parameters as well as tubal diseases among infertile women in Vietnam. Methodology: In this cross-sectional descriptive study, we enrolled 597 women undergoing infertility treatment at the Center for Reproductive Endocrinology & Infertility, Hue University Hospital, Vietnam. All of the study participants were interviewed and examined by a gynecologist. Consecutive tests were then conducted including direct microscopy examination (wet mount and Gram stain), vaginal culture, polymerase chain reaction (PCR) for chlamydia diagnosis from a cervical canal swab, and a blood test for syphilis detection. A hysterosalpingogram (HSG) was carried out to examine the uterine cavity and Fallopian tubes. Results: A gynecologic infection was diagnosed in 43.4% (259/597) of the infertile women. Bacterial vaginosis was the most common condition at 19.6%of the cases. Candida spp., Chlamydia trachomatis, and Trichomonas vaginalis infections accounted for 17.4%, 3.7%, and 0.3%, respectively. Normal HSG results accounted for 87.4% of the women while 5.5% had 2-sided tubal occlusions, 5.4% had 1-sided tubal occlusions, 1.0% had 1-sided hydrosalpinx, and 0.7% had 2-sided hydrosalpinx. There was no significant association between tubal diseases and current infections; however, aerobic vaginitis increased the risk of tubal diseases by 2.4 times. Conclusions: A marked proportion of infertile Vietnamese women have genital tract infections that can significantly influence their reproductive function and performance. These infections should be routinely screened and treated properly to prevent their consequences, such as infertility, which is especially important in developing countries.

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Aerobic vaginitis: no longer a stranger

Cited by 186 publications

References 91 publications

Pathobionts in the Vaginal Microbiota: Individual Participant Data Meta-Analysis of Three Sequencing Studies

Pathobionts in the Vaginal Microbiota: Individual Participant Data Meta-Analysis of Three Sequencing Studies

Prospective study of bidet toilet use: Association of abnormal vaginal colonization and preterm birth in high‐risk pregnant women

Is genital tract infection related to tubal diseases in infertile Vietnamese women?

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