*Aerobiologic and clinical aspects of mould allergy in Europe

D’Amato, Gennaro; Spieksma, F. Th. M.

doi:10.1111/j.1398-9995.1995.tb02492.x

Cited by 130 publications

(100 citation statements)

References 38 publications

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“…We predict with longer reads and more refined databases, identification of fungal taxa will become more accurate and resolution will reach the species/ strain level, and an even greater fungal diversity will be realized in the future. Aerial fungal diversity is regularly studied because fungal spores can cause human allergies and illnesses (D'amato and Spieksma, 1995;Garrett et al, 1998;Chew et al, 2000;Gioulekas et al, 2004). Allergies are induced by a large number of fungal genera, the majority of which are in Ascomycota.…”

Section: Discussionmentioning

confidence: 99%

Identifying airborne fungi in Seoul, Korea using metagenomics

Fong

Park

et al. 2014

J Microbiol.

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Fungal spores are widespread and common in the atmosphere. In this study, we use a metagenomic approach to study the fungal diversity in six total air samples collected from April to May 2012 in Seoul, Korea. This springtime period is important in Korea because of the peak in fungal spore concentration and Asian dust storms, although the year of this study (2012) was unique in that were no major Asian dust events. Clustering sequences for operational taxonomic unit (OTU) identification recovered 1,266 unique OTUs in the combined dataset, with between 223-396 OTUs present in individual samples. OTUs from three fungal phyla were identified. For Ascomycota, Davidiella (anamorph: Cladosporium) was the most common genus in all samples, often accounting for more than 50% of all sequences in a sample. Other common Ascomycota genera identified were Alternaria, Didymella, Khuskia, Geosmitha, Penicillium, and Aspergillus. While several Basidiomycota genera were observed, Chytridiomycota OTUs were only present in one sample. Consistency was observed within sampling days, but there was a large shift in species composition from Ascomycota dominant to Basidiomycota dominant in the middle of the sampling period. This marked change may have been caused by meteorological events. A potential set of 40 allergyinducing genera were identified, accounting for a large proportion of the diversity present (22.5-77.2%). Our study identifies high fungal diversity and potentially high levels of fungal allergens in springtime air of Korea, and provides a good baseline for future comparisons with Asian dust storms.

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Section: Discussionmentioning

confidence: 99%

Identifying airborne fungi in Seoul, Korea using metagenomics

Fong

Park

et al. 2014

J Microbiol.

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“…The possible causes of variability are the following: 1) intrinsic variation between spores and mycelium in antigen content; 2) somatic mutations causing allergen content changes within single culture; 3) aging and culture variable changes; 4) interstrain variability; and 5) interspecies variability. 15 The sorting effect is the weak antigen causing a greater number of mild reactions than severe or strong reactions. Alternaria alternata (also known as A. tenuis) is an extremely common species occurring in plants, soil, food, house dust and atmospheric samples, with optimal growth at 25°C-26°C.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship of airborne Alternaria and allergic diseases, particularly bronchial asthma, has been established by many workers in this field. [15][16][17][18] However, this has generally been done in vivo, by conducting skin prick test (SPT), and seldom by bronchial challenges or inhalation provocation tests. An in vitro test, such as the radioallergosorbent test (RAST), is often incorporated with the in vivo test.…”

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confidence: 99%

AirborneAlternariaSpores: Potential Allergic Sensitizers in Saudi Arabia

et al. 1998

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Background:In order to investigate the role of airborne Alternaria spp. in the sensitization of individuals having respiratory allergy symptoms, particularly bronchial asthma, an aerobiologic and clinical (diagnostic) study was conducted at several centers in Saudi Arabia. Materials and Methods: Airborne Alternaria spores were studied at four different centers in Riyadh, Jeddah and Al-Khobar, including three years at one site. Skin prick tests (SPT) were conducted on a total of 616 allergic individuals attending allergy clinics at six different hospitals in Abha, Qassim, Gizan, Jeddah, Hofuf and Makkah regions. Results: Alternaria spores constituted between 1.9%-9.6% of the total fungal air spora, and the maximum concentration exceeded 5x10 2 spores per m 3 of air in Jeddah, followed by 4.9x10 2 spores per m 3 in Al-Khobar. Mean weekly and monthly concentration of Alternaria fluctuated, reaching up to 150 spores per m 3 and 60 spores per m 3 , respectively. Quantitative regional variations were also recorded. IgE-mediated SPT reactivities conducted on allergic patients resulted in an overall 21.6% positive reactions, showing mild, moderate and strong wheal and erythema. Conclusion:The findings reveal that Alternaria spores are prevalent as a major component in the outdoor environment of the Kingdom, with peaks in April and October. The overall 21.6% positive SPT reactions indicate the sensitization level or cross-reactive sensitivity to Alternaria allergens. The study suggests that airborne Alternaria can be a potential allergic sensitizer in susceptible individuals and can be a risk factor in sensitized individuals with symptoms of bronchial asthma and allergic rhinitis in the Kingdom of Saudi Arabia.

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“…Studies of atmospheric air of various regions of Europe show that the spores of Cladosporium spp. dominate in 80% of all the caught spores (D'Amato & Spieksma, 1995) and the peak season is in the summer time (Lipiec, 2000). Some species are pathogenic to various crops, causing economically important plant diseases, while others are important only endemically.…”

Section: Pusz Et Almentioning

confidence: 99%