This study delves into the exploration of a distributed propulsion system consisting of three co-rotating propellers in front of a high-lift wing system, with a primary focus on understanding its acoustic characteristics. Employing high-fidelity computational fluid dynamics simulations, the flow field is simulated in climb condition. Subsequently, acoustic transport to far-field observers is conducted using the Ffowcs–Williams and Hawkings equation. Because the noise mechanisms of such a configuration are not fully understood yet, several permeable and impermeable surfaces as input for the acoustic simulation are used, aiming to separate the various noise source contributions. Results reveal that in addition to the rotor-alone noise from the propellers, noise arising from propeller–wing interaction emerges as dominant, emitting mostly at the blade passing frequency. Moreover, a boundary element method tool is applied to observe the scattering effect of propeller-generated noise by the wing. Furthermore, this study incorporates consideration of structural components in close proximity to the model, thereby achieving a more realistic acoustic field. With this knowledge, the simulation is validated with experimental data from an open wind tunnel test campaign. An overall good agreement is observed between the simulated and experimental results, substantiating the reliability of both aerodynamic and acoustic predictions.