In this work, the cycloidal rotor fan (CRF) performance was estimated by means of a numerical method based on Unsteady Reynolds Averaged Navier-Stokes equations (URANS). The fan with a cycloidal rotor belongs to the positive displacement machines of the rotary type. The numerical algorithm for simulation of the flow in the cycloidal rotor as well as postprocessing of the CFD results was prepared using Ansys CFX CEL. The methodology for the assessment of the CRF performance was proposed and verified. It was found out that the CRF performance strongly depends on the shape of the profile of the applied rotor blade. The NACA 0012 and CLARK Y profiles were tested for the same CRF structure and flow conditions. Also, the crucial importance for the CRF performance has the range of the blade pitch angle change.