As conventional upwind wind turbines grow larger, the increased mass and flexibility of the longer blades present challenges concerning costs, structural loads, and safety constraints such as tower clearance. At extreme scales, wind turbines in a downwind configuration may provide a feasible alternative to address these challenges by allowing lightweight, flexible blades that can reduce capital costs and blade loads while maintaining safety margins. Downwind turbine blades suffer from increased fatigue loading due to the tower shadow effect. In this study, novel downwind, three-bladed wind turbine designs at 25 MW rating with lightweight, flexible blades are evaluated and compared in terms of power production and structural loading. To obtain a baseline performance, a standard collective blade pitch wind turbine controller is implemented for the two downwind and one upwind turbine designs. Individual pitch control is then added for the downwind turbines to reduce structural fatigue on the turbine blades. In summary, the two downwind turbine designs that differ in rotor pre-coning and shaft tilt angles using collective and individual pitch control are compared against a conventional upwind turbine with collective pitch control at the same scale under turbulent wind conditions.