With regard to the current needs for greener aviation, this study focuses on a novel concept of Box-Wing Aircraft (BWA). Labelled SmartLiner (BWA/SL), this conceptual aircraft comes as a triplane comprising backward and forward swept wings. The aerodynamic performance and structural characteristics of this BWA/SL aircraft are here explored through numerical simulation, using Computational Fluid Dynamics (CFD) and Fluid-Structure Interaction (FSI). The computational approach is first validated using NASA’s Common Research Model (CRM) aircraft, which is then taken as a reference solution against which to compare the aero-structural merits of the BWA/SL concept. Results show that, although its design is still preliminary and lacks optimization, the BWA/SL aircraft exhibits very decent aerodynamic performance, with higher lifting capacities and a reasonable lift-to-drag ratio. Moreover, thanks to the closed frame of its peculiar planform, it demonstrates superior structural characteristics, including under extreme loading scenarios. Based on this preliminary analysis and considering the room left for its further optimization, this conceptual aircraft thus appears as a potentially promising alternative for the development of more environmentally friendly airliners.