In this article, one of the hazardous trouble in-flight situations called ice accumulation on wing leading edge of aircraft has been numerically investigated. While the target surface is kept constant temperature at Tw=263.15 K, the inlet temperature is taken constant at Tin=473.15 K and it enters to the system with 𝑚̇= 0.004 kg/s. The investigation starts with validation of numerical study utilizing airfoil type of NACA 0015 using constant piccolo tube dimensions, jet angle, distance among jets and distance between jet-to-target positions. The second and third stages are to analyze the anti-icing performance of changing positions of piccolo tube on X (4≤H/d≤8) and Y (-1.25≤L/d≤1.25) directions under different jet angles (30°≤≤150°). The fourth stage is to determine the optimum H/d, L/d, and ratios to increase anti-icing performance with maximum convective heat transfer and minimum pressure drop condition. The optimization study has been done using Response Surface Methodology (RSM). Finally, while the best anti-icing performance proposed design is achieved using° L/d=0.0, and H/d=4.0, the optimization results show that the L/d, and H/d values should be 55.45°, 0.0, and 4.0, respectively to achieve maximum heat transfer rate with minimum pressure drop value.