Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold

Cai, Hongli; Sharma, Sudhir Kumar; Liu, Wenying; Mu, Wei; Liu, Wei; Zhang, Xiaodan; Deng, Yulin

doi:10.1021/bm5003976

Cited by 191 publications

(142 citation statements)

References 43 publications

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“…A structural analog, bacterial cellulose, which is very difficult to process into complex 3D shapes, has shown promising results for simpler 3D structures such as artificial blood vessels/vascular grafts for bone and cartilage regeneration. CNF hydrogels support the adhesion and proliferation of human liver cells (HepG2 and HepaRG), human pluripotent stem cells (hPSCs), and mouse fibroblasts (NIH‐3T3) . ChNF‐based materials support the adhesion and proliferation of mouse and human fibroblasts, keratinocytes, and epithelial cells in vitro .…”

Section: Methodsmentioning

confidence: 99%

Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering

et al. 2015

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A sacrificial templating process using lithographically printed minimal surface structures allows complex de novo geo-metries of delicate hydrogel materials. The hydrogel scaffolds based on cellulose and chitin nanofibrils show differences in terms of attachment of human mesenchymal stem cells, and allow their differentiation into osteogenic outcomes. The approach here serves as a first example toward designer hydrogel scaffolds viable for biomimetic tissue engineering.

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Section: Methodsmentioning

confidence: 99%

Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering

et al. 2015

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“…In the scientific literature, there are reports of various applications of micro fibrillated cellulose based materials including, composites, barrier materials, tissue scaffolds, cell growth media, electronic materials, solar cells, and super capacitors [3][4][5][6][7][8][9][10] . Recently the production and potential application of micro fibrillated cellulose fibers have garnered much attention due to their excellent mechanical properties, biodegradability, and renewability.…”

Section: Introductionmentioning

confidence: 99%

Characterization of micro fibrillation process of cellulose and mercerized cellulose pulp

et al. 2015

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Here we detail the fibrillation process for cellulose and mercerized cellulose pulps. Native and mercerized cellulose showed high degree of purity as indicated by α -cellulose content measurement and XRD analysis. Furthermore, stark change in fiber morphology indicated aggregation of fibrils on the surface due to mercerization. Fibrillation of pulp was carried out in the in the following subsequent steps: Disintegration, PFI refining, microgrinding by 20 passes in SuperMassColloider, and 60 passes in SuperMassColloider. Fiber samples were collected at every stage and highly uniform films were made by ultrafiltration and hot press method. The fibers and films made from fibers were then characterized by measuring physical properties, contact angle, thermal, mechanical, and SEM analysis. The main objective was to characterize the physical properties of the films made from different degrees of fibrillation. The films obtained were of fairly close grammage approximately 35g/m 2 . The target grammage was 40g/m 2 , and the slightly lower grammage indicated some fiber loss during the fabrication process. Additionally, it was observed that the density of the films increased with increasing degree of fibrillation from about 180g/m 3 to 455g/m 3 for cellulose I and 95g/m 3 to 385g/m 3 for cellulose II. Cellulose I films showed some contact angle to begin with which increased at every stage (14° -64°), whereas cellulose II films did not display a contact angle until the final stage of fibrillation. The films also showed increasing strength and an evolution of tensile strength from initially displaying a tear behavior indicating poor bonding to typical micro fibrillated cellulose films behavior as the fibers became increasingly fibrillated. The ultimate tensile strength for cellulose changed from tear behavior with no defined break to 134.5MPa. While on the other hand, the same change for cellulose II was a maximum of 75.1MPa from tear behavior. Increasing fibrillation of fibrils in both cases showed a decrease in fiber size, well differentiated for the two types of pulps at every stage.

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“…In another case, cellulose aerogels are composed of “globules” attached to each other and their size decreases with the increase of cellulose concentration [106,107]. Moreover, Cai et al [108] demonstrated that ultralight pure natural aerogel microspheres can be fabricated using cellulose nanofibrials directly. The aerogel microspheres are highly porous with bulk density as low as 0.0018 g·cm −3 and pore size ranging from nanometers to micrometers.…”

Section: Structures and Properties Of Polymer/carbon-based Aerogelsmentioning

confidence: 99%

Polymer/Carbon-Based Hybrid Aerogels: Preparation, Properties and Applications

et al. 2015

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Aerogels are synthetic porous materials derived from sol-gel materials in which the liquid component has been replaced with gas to leave intact solid nanostructures without pore collapse. Recently, aerogels based on natural or synthetic polymers, called polymer or organic aerogels, have been widely explored due to their porous structures and unique properties, such as high specific surface area, low density, low thermal conductivity and dielectric constant. This paper gives a comprehensive review about the most recent progresses in preparation, structures and properties of polymer and their derived carbon-based aerogels, as well as their potential applications in various fields including energy storage, adsorption, thermal insulation and flame retardancy. To facilitate further research and development, the technical challenges are discussed, and several future research directions are also suggested in this review.

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Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold

Cited by 191 publications

References 43 publications

Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering

Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering

Characterization of micro fibrillation process of cellulose and mercerized cellulose pulp

Polymer/Carbon-Based Hybrid Aerogels: Preparation, Properties and Applications

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