Aeromonas Salmonicida as a causative agent for postoperative endophthalmitis

Varshney, Abhishek; Das, Manmath Kumar; Chaudhary, Priyanka; Kumari, Rashmi; Yadav, Kusha

doi:10.4103/meajo.meajo_238_17

Cited by 21 publications

(15 citation statements)

References 5 publications

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“…To the best of our knowledge, no systemic reports were regarding the isolation of A. salmonicida from clinical samples in China. Previous case reports have linked A. salmonicida to postoperative endophthalmitis, bacteremia and diarrhea 32,34,35. Instead, this present study uncovered that A. salmonicida was frequently isolated from sputum, hinting it as a potential causative pathogen to nosocomial pneumonia.…”

Section: Discussioncontrasting

confidence: 59%

Distinct Antimicrobial Resistance Profiling Of Clinically Important Aeromonas Spp. In Southwest China: A Seven-Year Surveillance Study

Jin

et al. 2019

IDR

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BackgroundCo-evolution of host and aeromonads has diversified their spectrums of diseases and antibiograms, while a paucity of data was concerning about this diversity in China. To fill this gap, this study was aimed to investigate and compare antimicrobial resistance (AMR) patterns of clinically important Aeromonas spp. from various clinical sources.MethodsA multicenter retrospective surveillance study was conducted in Chongqing from 2011 to 2017. Data of strains were retrieved from the database of China Antimicrobial Resistance Surveillance System (CARSS). Whonet 5.6 and Graphpad Prism 6 Software were adopted to determine and compare distribution and AMR patterns.ResultsAmong 1135 Aeromonas strains, Aeromonas hydrophila complex (65.6%, 745/1135) was the most predominant species, followed by Aeromonas veronii complex (16.7%, 190/1135) and Aeromonas caviae complex (15.3%, 174/1135). Sputum was the most frequent source of strains (27.7%), followed by wound (20.8%), bloodstream (10.8%) and urine (8.8%). Urinary strains demonstrated the highest resistance rates to ceftriaxone (65.6%), ceftazidime (52.1%), cefepime (38.3%), ciprofloxacin (47.7%) and trimethoprim-sulfamethoxazole (56.6%). Similar AMR pattern was observed in intestinal strains, with corresponding resistance rates of 29.4%, 28.9%, 22.2%, 27.3% and 45%, respectively. However, respiratory, bloodstream and skin strains exhibited resistance rates of less than 20% to most of the antimicrobials tested. In terms of species, approximately 30% of Aeromonas hydrophila complex and Aeromonas caviae complex strains were resistant to ceftriaxone and trimethoprim-sulfamethoxazole, while Aeromonas veronii complex strains harbored resistance rates of less than 20% to all tested antimicrobials. Although antibiograms of these species were distinct, they remained constant from 2011 to 2017.ConclusionsDistinct AMR patterns between species and sources highlighted the predominance of Aeromonas hydrophila complex and high resistance of strains in urine and intestine to extended-spectrum cephalosporins, ciprofloxacin and trimethoprim-sulfamethoxazole in Southwest China. Temporally constant AMR patterns should not relax the vigilance of antimicrobial resistance in clinically important Aeromonas species.

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Section: Discussioncontrasting

confidence: 59%

Distinct Antimicrobial Resistance Profiling Of Clinically Important Aeromonas Spp. In Southwest China: A Seven-Year Surveillance Study

Jin

et al. 2019

IDR

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“…Few are the cases of the isolation of A. salmonicida from samples of clinical origin. Aeromonas salmonicida has been previously isolated from blood samples from patients with typical symptoms of bacterial sepsis [39] and postoperative endophthalmitis [40]. Even though the strains were mainly of intestinal origin, they were also isolated from patients with other diagnoses (other than gastroenteritis), such as septic conditions, renal failure, urinary tract infection, and tissue lesions.…”

Section: Discussionmentioning

confidence: 99%

Genetic and phenotypic determinants of resistance to antibiotics in Aeromonas spp., strains isolated from pediatric patients

Bello–López

Sánchez-Garibay

Ibáñez-Cervantes

et al. 2020

J Infect Dev Ctries

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Introduction: Intestinal and extraintestinal infections by Aeromonas spp., remain controversial, due to the existence of healthy carriers of Aeromonas spp. In children under five years old, the diarrhea of infectious origin constitutes the second cause of mortality and remains a major concern for public health. The aim of this work was to detect the pheno/genotype of β-lactamases and class 1 integrons in Aeromonas spp., strains isolated from pediatric patients in a tertiary referral hospital in Mexico. Methodology: Sixty-six strains of Aeromonas spp., were isolated from clinical samples of pediatric origin and were identified by RFLP-PCR 16S rRNA. Resistance phenotype according to CLSI, genetic and phenotypic detection of extended-spectrum β-lactamases (ESBL) and metallo-b-lactamases (MBL) was performed. Finally, characterization of class 1 integrons was performed. Results: Aeromonas spp., strains of diarrheic origin were more predominant. A wide heterogeneity was detected, where A. caviae was the predominant specie. Second-generation cephalosporins, fluoroquinolones, and nitrofurans had best antimicrobial activity; moreover, antibiotics of the β-lactamic and lincosamides families showed lower inhibitory activity. Phenotypically, prevalences of 4.55% and 3.03% were detected for MBL (intestinal origin) and ESBL (extraintestinal origin), respectively. blaIMIS-cphA and blaTEM-1 genes, and nineteen class 1 integrons carrying two variants of cassettes corresponding to adenylyl transferases (aadA), and dihydrofolate reductases (dfrA). Monogenic array with aadA1 cassette was predominantly. Conclusions: ESBL and class 1 integrons, in Aeromonas collected from pediatric patients, determines a major detection challenge for the clinical microbiology laboratory and represents a remarkable epidemiological risk of nosocomial spread of multidrug-resistant determinants.

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“…Ann Moore 6 /2017Survived(poor visual)yesamikacin 125 μg/0.1 ml/intravitreal injectionssensitivefor amikacin, gentamicin and colistinAqueous humor andvitreous aspirate/Endophthalmitisocularpain, discharge, and gradual decreaseof visioncataractsurgeryf55yA. Varshney 4 /2017Survivedyesceftriaxone 1 g/BD/IV for 4 weeks and then cefexim 400 mg /daily for 4 weeksall the drugsBlood and valve vegetationweakness and intermittent feverrheumatic heart diseasem20yM.Salehi/2019…”

Section: Discussionmentioning

confidence: 99%

“…The organism is a facultative oxidase positive and Gram-negative low virulence bacillus, commonly found in water and soil. However, in recent years due to the use of improved techniques for isolation and identification of bacteria from biological specimens such as BACTT/ALERT and Vitek 2-compact system, there have been numerous reports of various human and animal infections caused by Aeromonas spp , mainly from Asian countries [[2], [3], [4]]. The most common manifestations of infection with Aeromonas include gastroenteritis, bacteremia, and soft tissue infections [3].…”

Section: Introductionmentioning

confidence: 99%

Endocarditis with Aeromonas salmonicida

Salehi

Shadvar

Sadeghian

et al. 2019

IDCases

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Aeromonas salmonicida (A. salmonicida) is a facultative Gram-negative bacillus, inhabiting in water. It is a common source of furunculosis and septicemia in fish. Report on the human infection with this organism is rare. A male farmer referred with weakness and intermittent fever. He had cardiac valves’ regurgitation due to fever with rheumatic heart disease. He had a history of swimming in well water. Transthoracic echocardiography (TTE) revealed a mobile mass of 1.3 × 0.9 cm attached to the mitral valve chordae, suggestive of a vegetation. Aeromonas salmonicida was isolated from the blood. After cardiac surgery and taking ceftriaxone for 4 weeks, he was discharged in good general condition. Five previous case reports of human infection with this organism were found. The patient was the sixth human case, and the first endocarditis, reported with this organism. A. salmonicida is a rare agent for human infection. Contact with water is a risk factor for this type of infection. It seems that the use of modern diagnostic methods has been effective in identifying the microorganism.

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Aeromonas Salmonicida as a causative agent for postoperative endophthalmitis

Cited by 21 publications

References 5 publications

<p>Distinct Antimicrobial Resistance Profiling Of Clinically Important <em>Aeromonas</em> Spp. In Southwest China: A Seven-Year Surveillance Study</p>

<p>Distinct Antimicrobial Resistance Profiling Of Clinically Important <em>Aeromonas</em> Spp. In Southwest China: A Seven-Year Surveillance Study</p>

Genetic and phenotypic determinants of resistance to antibiotics in Aeromonas spp., strains isolated from pediatric patients

Endocarditis with Aeromonas salmonicida

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