Aeromonas toxins

Ljungh, Åsa; Wadström, Torkel

doi:10.1016/0163-7258(81)90049-8

Cited by 64 publications

(47 citation statements)

References 64 publications

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“…Poor correlation between haemolysis of rabbit erythrocytes and enterotoxin production as measured by the suckling mouse test, has been reported by Okitsu and colleagues [41]. The situation is further complicated by reports that aeromonads possess at least two different haemolysins with cytotoxic activity [42] and that A. hydrophila may also produce another cytotoxin which is devoid of haemolytic activity [10].…”

Section: Discussionmentioning

confidence: 99%

The incidence of virulence factors in mesophilicAeromonasspecies isolated from farm animals and their environment

Stickler

Bryant

1990

Epidemiol. Infect.

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SUMMARYSixty-one isolates of Aeromonas spp. from the faeces of pigs, cows and a variety of associated environmental sources were examined for the characteristics that are reputed to have roles in pathogenicity. Most isolates ofAeromonas hydrophila were cytotoxic (96-4%) and were capable of producing cell elongation factor (75%) and haemagglutinins (67-9 %). In contrast few of the Aeromonas caviae isolates produced these three markers (13-6 %, 27-3% and 36-4 % respectively). In general, Aeromonas sobria occupied an intermediate position (36'4 %, 27-3% and 545%), but they did produce the highest mean invasion index for HEp-2 cells. Statistical analysis revealed significant associations between the carriage of these factors and it was clear that many isolates of aeromonads from water and animals possessed the full battery of putative virulence factors.

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Section: Discussionmentioning

confidence: 99%

The incidence of virulence factors in mesophilicAeromonasspecies isolated from farm animals and their environment

Stickler

Bryant

1990

Epidemiol. Infect.

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“…Outbreaks of motile aeromonad septicaemia usually occur only when the fish are immunocompromised by stresses such as overcrowding or concurrent disease (Stevenson, 1988). A. hydrophila produces several virulence determinants, including cytotoxins and enterotoxins (Ljungh & Wadstrom, 1982 ;Yadav et al, 1992) and a repertoire of enzymes that digest cellular components, mostly proteases and haemolysins (Allan & Stevenson, 1981 ; Leung & Stevenson, 1988). Other virulence factors such as the S layer (Dooley & Trust, 1988) and serum resistance (Mittal et al, 1980;Leung et af., 1995) are also implicated in aiding bacterial resistance to attack by the host's non-specific immune mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor

et al. 1998

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Aeromonas hydrophila is a Gram-negative bacterium that is pathogenic in fish, causing motile aeromonad septicaemia. It can enter (invade) fish cells, and survive as an intracellular parasite. The host-pathogen interaction and signal transduction pathway were studied by screening signal transduction inhibitors using carp epithelial cells and a virulent strain of the bacterium, PPDl34/91. Genistein, a tyrosine kinase inhibitor, postponed internalization of A. hydrophila into host cells, suggesting that tyrosine phosphorylation plays a role in internalization. In contrast, staurosporine, a protein kinase C inhibitor, and sodium orthovanadate, a protein tyrosine phosphatase inhibitor, accelerated internalization of PPD134/91. Other virulent strains of A. hydrophila were also examined and it is likely that all strains, irrespective of serogroup, use the same signalling pathway to facilitate bacterial uptake.

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“…Aeromonas bacteria have frequently been iso lated from EUS lesions (Anonymous, 1986;Llobrera and Gacutan, 1987;Torres et al, 1990;Subasinghe et al, 1990;Roberts et al, 1990). This organism pos sesses the potential to produce a wide range of virulence factors including cytotoxins, haemolysins, proteases and nucleases (Ljungh and Wadstrom, 1986;Cahill, 1990). These evidences support that this bacterium may play an important role to cause EUS.…”

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confidence: 99%

Phenotypic and Genotypic Identification of Motile Aeromonads Isolated from Fish with Epizootic Ulcerative Syndrome in Southeast Asian Countries.

et al. 1998

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The phenotypic properties and genotypic characteristics of 44 aeromonads isolated from fish affected by epizootic ulcerative syndrome (EUS) in Southeast Asia were investigated. Among the 13 A. hydrophila phenospecies 9 were genotypically identical to A. hydrophila (HG 1) and 4 were A. veronii biotype sobria (HG8Y) or A. veronii biotype sobria-related genospecies. All the 6 A. veronii biotype sobria phenospecies were placed in the same genospecies, A. veronii biotype sobria. Of the 12 A. jandaei phenospecies, 5 were A. veronii biotype sobria or A. veronii biotype sobria-related genospecies and 7 were A. jandaei genospecies. Of 13 Aeromonas isolates unspeciated by phenotyping 9 were genotypically identical to A. hydrophila or very similar to A. hydrophila and 2 isolates were A. veronii biotype sobria or very similar to A. veronii biotype sobria; 2 isolates could not be identified to genospecies level. These results strongly suggest that Aeromonas species from fish affected by EUS could not correctly be identified to the species level using various published biochemical schemes; it needs genetic identification like DNA-DNA hybridization.

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Aeromonas toxins

Cited by 64 publications

References 64 publications

The incidence of virulence factors in mesophilicAeromonasspecies isolated from farm animals and their environment

The incidence of virulence factors in mesophilicAeromonasspecies isolated from farm animals and their environment

Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor

Phenotypic and Genotypic Identification of Motile Aeromonads Isolated from Fish with Epizootic Ulcerative Syndrome in Southeast Asian Countries.

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