Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial

Liu, Harris; Kim, Yoojeong; Mello, Kerrianne; Lovaasen, John; Shah, Anup; Rice, Norman; Yim, Jacqueline H.; Pappas, Daphne; Klibanov, Alexander M.

doi:10.1007/s12010-013-0593-4

Cited by 12 publications

(12 citation statements)

References 15 publications

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“…In another approach for coating the polycations, a study by Liu et al demonstrated use of N , N -hexyl,methyl-polyethylenimine with an aerosol-assisted plasma deposition technique on glass surfaces. 89 This allows for the covalent immobilization of N , N -hexyl,methyl-polyethylenimine through a one-step method and has been shown to be thermally stable (up to 150 °C) and durable upon exposure to vigorous washes and exposure to detergents. This study demonstrated a greater than 4-log reduction in the influenza H1N1 virus for N , N -hexyl,methyl-polyethylenimine-treated surfaces.…”

Section: Polymeric and Organic Antiviral Coatingsmentioning

confidence: 99%

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Antimicrobial Nanomaterials and Coatings: Current Mechanisms and Future Perspectives to Control the Spread of Viruses Including SARS-CoV-2

et al. 2020

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The global COVID-19 pandemic has attracted considerable attention toward innovative methods and technologies for suppressing the spread of viruses. Transmission via contaminated surfaces has been recognized as an important route for spreading SARS-CoV-2. Although significant efforts have been made to develop antibacterial surface coatings, the literature remains scarce for a systematic study on broad-range antiviral coatings. Here, we aim to provide a comprehensive overview of the antiviral materials and coatings that could be implemented for suppressing the spread of SARS-CoV-2 via contaminated surfaces. We discuss the mechanism of operation and effectivity of several types of inorganic and organic materials, in the bulk and nanomaterial form, and assess the possibility of implementing these as antiviral coatings. Toxicity and environmental concerns are also discussed for the presented approaches. Finally, we present future perspectives with regards to emerging antimicrobial technologies such as omniphobic surfaces and assess their potential in suppressing surface-mediated virus transfer. Although some of these emerging technologies have not yet been tested directly as antiviral coatings, they hold great potential for designing the next generation of antiviral surfaces.

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Section: Polymeric and Organic Antiviral Coatingsmentioning

confidence: 99%

“…This study demonstrated a greater than 4-log reduction in the influenza H1N1 virus for N , N -hexyl,methyl-polyethylenimine-treated surfaces. 89 …”

Section: Polymeric and Organic Antiviral Coatingsmentioning

confidence: 99%

Antimicrobial Nanomaterials and Coatings: Current Mechanisms and Future Perspectives to Control the Spread of Viruses Including SARS-CoV-2

et al. 2020

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“…In one example study, Liu et al covalently immobilized N, N-hexyl, methyl-PEI (HMPEI) using an atmospheric-pressure plasma liquid deposition method. They showed that HMPEI-coated glass slides generated by plasma exposure reduced the viral titer of human influenza A (H1N1) virus compared to control, as well as the bacterial titer of waterborne E. coli [93].…”

Section: Cationic Polymersmentioning

confidence: 99%

Nanotechnology-Based Antimicrobial and Antiviral Surface Coating Strategies

2021

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Biocontamination of medical devices and implants is a growing issue that causes medical complications and increased expenses. In the fight against biocontamination, developing synthetic surfaces, which reduce the adhesion of microbes and provide biocidal activity or combinatory effects, has emerged as a major global strategy. Advances in nanotechnology and biological sciences have made it possible to design smart surfaces for decreasing infections. Nevertheless, the clinical performance of these surfaces is highly depending on the choice of material. This review focuses on the antimicrobial surfaces with functional material coatings, such as cationic polymers, metal coatings and antifouling micro-/nanostructures. One of the highlights of the review is providing insights into the virus-inactivating surface development, which might particularly be useful for controlling the currently confronted pandemic coronavirus disease 2019 (COVID-19). The nanotechnology-based strategies presented here might be beneficial to produce materials that reduce or prevent the transmission of airborne viral droplets, once applied to biomedical devices and protective equipment of medical workers. Overall, this review compiles existing studies in this broad field by focusing on the recent related developments, draws attention to the possible activity mechanisms, discusses the key challenges and provides future recommendations for developing new, efficient antimicrobial and antiviral surface coatings.

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“…[ 266 ] N , N ‐hexyl,methyl‐PEI (HMPEI) has also been investigated as a candidate for coating deposited via an aerosol‐assisted plasma method and exhibited virucidal properties. [ 136 ] However, the cytotoxicity of DMPEI and its correlation with antiviral activity should be explored for clinical applications. [ 133 ] Hydrophobic and cationic polyacrylamides and acrylate‐based polymers exhibit virucidal activity against enveloped [ 138 ] and nonenveloped viruses.…”

Section: Polymers Against Virusesmentioning

confidence: 99%

“…The antiviral polymers mentioned above have been commonly studied for their therapeutic applications. However, some of these polymers with extracellular and direct antiviral activity have also been successfully applied as coatings [ 136 ] and in food. [ 270,271 ] Thus, the redirection of these materials for other purposes, such as for “self‐sanitizing surfaces,” is plausible and should be further explored.…”

Section: Polymers Against Virusesmentioning

confidence: 99%

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Rodrigues

Campo

Arns

et al. 2021

Part & Part Syst Charact

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Infectious diseases caused by viruses are a global health concern and have become prominent in light of the recent COVID‐19 pandemic. Considering the limitations of drugs and prophylactic methods used in current medicine, antiviral materials are a useful strategy in preventing the spread of viruses and enhancing treatment efficiency. Thus, this review highlights the state‐of‐the‐art antiviral materials, describes the scientific landscape of the primary antiviral materials used based on bibliometric analysis, presents their mechanisms of action, and discusses their clinical applications. The mechanisms of action underlying the broad‐spectrum antiviral properties of metals, ceramics, polymers, and composites are also discussed. Polyanions, polycations, oxides, and metal‐based materials, from bulk to nanoparticles, have good potential in antiviral applications that may help prepare the world for future viral breakouts.

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Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial

Cited by 12 publications

References 15 publications

Antimicrobial Nanomaterials and Coatings: Current Mechanisms and Future Perspectives to Control the Spread of Viruses Including SARS-CoV-2

Antimicrobial Nanomaterials and Coatings: Current Mechanisms and Future Perspectives to Control the Spread of Viruses Including SARS-CoV-2

Nanotechnology-Based Antimicrobial and Antiviral Surface Coating Strategies

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

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