In this issue of JAMA, Wang et al present evidence that universal masking of health care workers (HCWs) and patients can help reduce transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. 1 In the largest health care system in Massachusetts with more than 75 000 employees, in tandem with routine symptom screening and diagnostic testing of symptomatic HCWs for SARS-CoV-2 infection, leadership mandated a policy of universal masking for all HCWs as well as for all patients. The authors present data that prior to implementation of universal masking in late March 2020, new infections among HCWs with direct or indirect patient contact were increasing exponentially, from 0% to 21.3% (a mean increase of 1.16% per day). However, after the universal masking policy was in place, the proportion of symptomatic HCWs with positive test results steadily declined, from 14.7% to 11.5% (a mean decrease of 0.49% per day). Although not a randomized clinical trial, this study provides critically important data to emphasize that masking helps prevent transmission of SARS-CoV-2.This change and its association with universal masking is unlikely to be artifactual; throughout the intervention, the number of symptomatic HCWs tested per day appears to have remained steady, while at the same time the daily number of new SARS-CoV-2 infections in the greater Massachusetts community was continuing to increase or had plateaued. 2 An artifactual flattening or decline in the rate of newly diagnosed SARS-CoV-2 infections when the rates were actually unchanged by the intervention could have occurred if, during the intervention period, a competing etiology for the symptoms that prompted SARS-CoV-2 testing among HCWs, such as influenza, had been trending more rapidly upward; however, weekly rates of diagnosed influenza in Massachusetts were low and approaching zero during this time. 3 The authors rightly note that other community-wide and hospital-specific interventions may have contributed to their observation, including the statewide declaration of emergency (March 10), new hospital policies to restrict visitors (March 12) and elective procedures (March 14), statewide school closures and hospital restrictions on business travel and on-site working (March 16), local public transportation reductions (March 17), issuance of statewide stay-at-home orders (March 24), and automation of screening and testing (March 30). 4 Nonetheless, it was only after the universal masking policy had been in operation for approximately a week that the temporal trend in positivity